研究目的
To determine the value of spectral domain optical coherence tomography (SD-OCT) in assessing patients with diffuse unilateral subacute neuroretinitis (DUSN) and to understand the pathogenesis of the disease.
研究成果
SD-OCT is a valuable noninvasive tool for assessing DUSN, showing significant atrophy in macular and retinal nerve fiber layer thickness but no significant change in choroidal thickness. This helps explain visual function loss and aids in diagnosis and monitoring, with implications for understanding disease pathogenesis.
研究不足
The study is limited by its small sample size of ten patients and its observational nature, which may not account for all variables. The manual segmentation of choroidal thickness could introduce variability, and the findings may not be generalizable to all DUSN cases due to the specific patient population.
1：Experimental Design and Method Selection:
An observational case series with clinical imaging correlation was conducted. SD-OCT with enhanced depth imaging was used to assess retinal layers.
2：Sample Selection and Data Sources:
Ten consecutive patients with confirmed DUSN diagnosis (seven late-stage, three early-stage) were selected from the Retina and Vitreous Institute of Londrina and State University of Londrina.
3：List of Experimental Equipment and Materials:
Heidelberg Spectralis? SD-OCT device, enhanced depth imaging software version
4：2, Heidelberg Eye Explore software, Statistical Package for the Social Sciences version 19 software. Experimental Procedures and Operational Workflow:
Patients underwent full ophthalmologic examination, including color fundus photography, near infrared wavelength fundus autofluorescence, and SD-OCT. Measurements included mean macular thickness, retinal nerve fiber layer thickness, and choroidal thickness using specific scan patterns and manual segmentation.
5：Data Analysis Methods:
Statistical analysis was performed using the Wilcoxon test for dependent samples to compare affected and healthy eyes, with a P-value ≤0.05 considered significant.
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