1：Experimental Design and Method Selection:

The study involved synthesizing CDHA–MGO nanocomposites by grafting β-cyclodextrin–hyaluronic acid polymers to Fe3O4–graphene oxide. Methods included chemical synthesis, characterization using various techniques, drug loading and release studies, and in vitro cytotoxicity assays.

2：Sample Selection and Data Sources:

Materials were purchased from suppliers like Macklin, Aladdin, Sigma-Aldrich, etc. Human hepatoma cell line BEL-7402 was used for cellular studies.

3：List of Experimental Equipment and Materials:

Equipment included FT-IR spectrometer (Bruker Tensor 27), TEM (FEI Tecnai G2 F30), XRD (Bruker D8 Advance), TGA (TA Instruments Q50), VSM (Quantum Design Verslab), Zetasizer Nano-Zs, UV-Vis-NIR spectrometer (Lambda-950), fluorescence spectrophotometer (FP-8300), inverted fluorescent microscope (Olympus IX70), NMR spectrometer (Bruker AVANCE III HD-600 MHz), Milli-Q Plus water system, and an 808 nm NIR laser.

4：Experimental Procedures and Operational Workflow:

Synthesis of MGO and CDHA–MGO, characterization, drug loading with DOX, photothermal heating measurements, drug release studies under different pH and NIR conditions, cellular uptake assays, and MTT assays for cytotoxicity.

5：Data Analysis Methods:

Data were analyzed using kinetic models (pseudo-first-order and pseudo-second-order), isotherm models (Langmuir and Freundlich), and statistical analysis for cell viability.