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Cell viability assessments of green synthesized water-soluble AgInS <sub/>2</sub> /ZnS core/shell quantum dots against different cancer cell lines
摘要： Chalcopyrite quantum dots (QDs) have emerged as a safe alternative to cadmium-based QDs for bio-applications. However, the research on AgInS2 chalcopyrite QDs has not been widely explored in terms of their toxicity. Herein, we report a synthesis of biocompatible AgInS2/ZnS QDs via a greener approach. The emission intensity of the as-synthesized AgInS2 core QDs was enhanced 2-fold after the ZnS shell growth. X-ray diffraction revealed the tetragonal crystal structure of QDs, and high-resolution transmission electron microscope images show that the QDs are spherical in shape and crystalline in nature. Cell viability assays conducted on different cell lines, such as HeLa, A549, and BHK-21 cells, indicated that AgInS2/ZnS QDs are least toxic at a QD concentration range of 100 lg/mL. The ?uorescent microscope analysis of A549 cells incubated with AgInS2/ZnS QDs shows that the QDs were accumulated in the cell membranes. The as-synthesized AgInS2/ZnS QDs are less toxic and eco-friendly, and can be used for biolabeling.
关键词： cell viability,AgInS2/ZnS,biolabeling,Chalcopyrite quantum dots,biocompatibility
更新于2025-11-19 16:46:39
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Investigation of AgInS2/ZnS Quantum Dots by Magnetic Circular Dichroism Spectroscopy
摘要： Over recent years, quantum dots (QDs) based on ternary metal dichalcogenides have attracted a lot of attention due to their unique properties and a range of potential applications. Here, we review the latest studies on the optical properties of AgInS2/ZnS QDs with emphasis on their theoretical modeling, and present our investigations of electronic transitions invisible in unstructured absorption spectra of AgInS2/ZnS QDs. The analysis of the absorption, photoluminescence excitation (PLE), and magnetic circular dichroism (MCD) spectra of hydrophobic and hydrophilic AgInS2/ZnS QDs of different sizes enables us to determine positions of electron transitions in these QDs. We demonstrate that the use of the second derivative of PLE spectra provides more unequivocal data on the position of the energy transitions compared with the second derivative of absorption spectra. Analysis of the MCD spectra reveals that the magnetic field induces energy level mixing in AgInS2/ZnS QDs in contrast to the traditional Cd-based QDs, where MCD is associated only with removing degeneracy of the excited energy level.
关键词： AgInS2/ZnS,electronic transitions,magnetic circular dichroism,AIS,ternary quantum dots
更新于2025-09-12 10:27:22