- 标题
- 摘要
- 关键词
- 实验方案
- 产品
-
Antimicrobial photodynamic inactivation of fungal biofilm using amino functionalized mesoporus silica-rose bengal nanoconjugate against Candida albicans
摘要： Candida albicans is an opportunistic fungal pathogen that causes both superficial and systemic infection and an important candidate that contribute to high morbidity and mortality rates in immunocompromised patients. The ability of C. albicans to switch from yeast to filamentous form and thereby forming biofilms make them resistant to most of the antifungal drugs available today. Thus the development of more effective antifungal drugs are essential and crucial at this point of time. Antimicrobial photodynamic therapy is an alternative modality to treat such biofilm forming resistant strains. This study aims to investigate the enhanced efficiency of newly synthesized MSN-RB conjugate as an antimicrobial photosensitizer for antimicrobial photodynamic therapy against C. albicans. Functionalization of MSN with amino groups was performed to increase the dye loading capacity. Conjugation process of MSN-RB was confirmed using different techniques including UV–Vis spectroscopy, Fluorescent spectroscopy and FTIR analysis. A low power green laser 50 mW irradiation was applied (5 min) for activation of MSN-RB conjugate and RB against C. albicans biofilm and planktonic cell. The comparative study of MSN-RB conjugate and free RB on aPDT was evaluated using standard experimental procedures. Antibiofilm efficacy was determined using biofilm inhibition assay, cell viability, EPS quantification and CLSM studies. The results revealed that MSN-RB conjugate has a significant antimicrobial activity (88.62 ± 3.4%) and antibiofilm effect on C. albicans when compared to free dye after light irradiation. The MSN-RB conjugate based aPDT can be employed effectively in treatment of C. albicans infections.
关键词： Antimicrobial photodynamic therapy,Conjugation,Amino functionalization,Mesoporus silica nanoparticles,Lipid peroxidation,Anti-biofilm activity
更新于2025-09-23 15:23:52
-
A Dual Role of Amino-functionalized Graphene Quantum Dots in NiOx Films for Efficient Inverted Flexible Perovskite Solar Cells
摘要： NiOx has been widely used as an effective hole transport material for inverted perovskite solar cells (PSCs), particularly flexible PSCs, owing to its low-temperature processing, low cost, and good electron blocking ability. However, the band structure alignment between low-temperature-processed NiOx and the perovskite layer is not satisfactory, resulting in reduced photovoltaic performance. Herein, we report a novel strategy to tune the NiOx hole transport layer for achieving high-performance flexible PSCs. Amino-functionalized graphene quantum dots (AGQDs) are employed in the NiOx film as a dual-role additive. On the one hand, the added AGQDs can provide abundant N atoms at the modified NiOx layer surface to enhance the crystallization of the perovskite film by a Lewis base-acid interaction. On the other hand, the AGQDs can optimize the band structure alignment between the NiOx and perovskite layers, facilitating hole extraction at the NiOx/perovskite interface. As a result, the inverted flexible PSCs exhibit a champion efficiency of 18.10%, which is comparable to the values reported for the current state-of-the-art inverted flexible PSCs. In addition to good air stability, our best flexible device has excellent mechanical stability, retaining 88% of its initial efficiency after continuously bending 1000 times. This new strategy highlights a promising way to enhance the performance of inverted flexible PSCs.
关键词： flexible,amino functionalization,graphene quantum dots,NiO,inverted perovskite solar cells
更新于2025-09-16 10:30:52