- 标题
- 摘要
- 关键词
- 实验方案
- 产品
-
Polarization-Sensitive Optical Coherence Tomography for Brain Tumor Characterization
摘要： Complete removal of brain tumor is of the most interest to a surgeon because the resection area directly relates to recurrence rate. Although there are many biomedical imaging modalities applied to locate the positions of tumors, they lack the spatial resolution to precisely delineate the boundary between brain tumor and normal brain tissues and are also inconvenient to be used intraoperatively. This study aims to examine the feasibility of label-free, polarization-sensitive optical coherence tomography (PS-OCT) for distinguishing brain tumors from normal brain tissues. Ex vivo samples were obtained from two patients with grade II and II-III glioma; healthy porcine brain tissues were utilized as the control group. In the results obtained from normal porcine brain, white matter contains significantly higher birefringent property over grey matter indicated by phase retardation. Based on the knowledge obtained from porcine brain experiment, a similar high-birefringent tissue is observed partially on the edge of the sliced glioma, and such tissue is considered as white matter because glioma originates through the mutation of the healthy white matter's glia cells. Additionally, differences between grey matter and brain tumor are not apparent based on phase retardation images and further histogram analysis. The capability of PS-OCT for distinguishing glioma from white matter is demonstrated. It could be a potential system to facilitate safe and maximum resection area, and finally, lead to ameliorated outcomes.
关键词： optical polarization,white matter,Brain tumor,optical coherence tomography
更新于2025-09-23 15:22:29
-
Optical scanning holography for tumor extraction from brain magnetic resonance images
摘要： Tumor segmentation from magnetic resonance images (MRI) is an error-prone and time-absorbing process. Recently, optical methods have opened a new avenue to tack with the aforementioned problem. In this paper, we propose a novel architecture adapting the Optical Scanning Holography (OSH) to the detection of the abnormal tissue regions in MRI. The proposed method combines an o?-axis optical scan, performed by a heterodyne fringe pattern, and a MR image display ensured by a spatial light modulator. The output in-phase component of the scanned current is collected digitally. Hence, a high-precision distribution of biological tissues is extracted using this in-phase component. Its maximum position is exactly the one of the tumor. Meanwhile, this position is used in an Active Contour Model (ACM) to perform a fast segmentation of the extent corresponding to the tumors. Several images of brain tumors from BRATS database, with tumors having di?erent contrast and form, are used to test the proposed system. Parameters reverted by the optical process are used to investigate the detection performance. Further, in terms of tumor segmentation, the proposed OSH-ACM process has high performance metrics compared to some of recently published method. The underlying physics of the precision superiority, presented by the OSH-ACM, is the high-precision extraction of the abnormal tissue regions by the in-phase component of the scanned current.
关键词： Active contour,Optical Scanning Holography (OSH),Segmentation,Brain tumor detection,In-phase component of the scanned current
更新于2025-09-23 15:21:01
-
Laser Ablation of Abnormal Neurological Tissue Using Robotic NeuroBlate System (LAANTERN): 12-Month Outcomes and Quality of Life After Brain Tumor Ablation
摘要： Laser Ablation of Abnormal Neurological Tissue using Robotic NeuroBlate System (LAANTERN) is an ongoing multicenter prospective NeuroBlate (Monteris Medical) LITT (laser interstitial thermal therapy) registry collecting real-world outcomes and quality-of-life (QoL) data. To compare 12-mo outcomes from all subjects undergoing LITT for intracranial tumors/neoplasms. Demographics, intraprocedural data, adverse events, QoL, hospitalizations, health economics, and survival data are collected; standard data management and monitoring occur. A total of 14 centers enrolled 223 subjects; the median follow-up was 223 d. There were 119 (53.4%) females and 104 (46.6%) males. The median age was 54.3 yr (range 3-86) and 72.6% had at least 1 baseline comorbidity. The median baseline Karnofsky Performance Score (KPS) was 90. Of the ablated tumors, 131 were primary and 92 were metastatic. Most patients with primary tumors had high-grade gliomas (80.9%). Patients with metastatic cancer had recurrence (50.6%) or radiation necrosis (40%). The median postprocedure hospital stay was 33.4 h (12.7-733.4). The 1-yr estimated survival rate was 73%, and this was not impacted by disease etiology. Patient-reported QoL as assessed by the Functional Assessment of Cancer Therapy-Brain was stabilized postprocedure. KPS declined by an average of 5.7 to 10.5 points postprocedure; however, 50.5% had stabilized/improved KPS at 6 mo. There were no significant differences in KPS or QoL between patients with metastatic vs primary tumors. Results from the ongoing LAANTERN registry demonstrate that LITT stabilizes and improves QoL from baseline levels in a malignant brain tumor patient population with high rates of comorbidities. Overall survival was better than anticipated for a real-world registry and comparative to published literature.
关键词： Brain tumor,Laser ablation,Quality of life,LITT,Survival
更新于2025-09-23 15:19:57
-
Laser interstitial thermal therapy
摘要： Background. Laser interstitial thermal therapy (LITT) is becoming an increasingly popular technique for the treatment of brain lesions. More minimally invasive that open craniotomy for lesion resection, LITT may be more appropriate for lesions that are harder to access through an open approach, deeper lesions, and for patients who may not tolerate open surgery. Methods. A search of the current primary literature on LITT for brain lesions on PubMed was performed. These studies were reviewed and updates on the radiological, pathological, and long-term outcomes after LITT for brain metastases, primary brain tumors, and radiation necrosis as well as common complications are included. Results. Larger extent of ablation and LITT as frontline treatment were potential predictors of favorable progression-free and overall survival for primary brain tumors. In brain metastases, larger extent of ablation was more significantly associated with survival benefit, whereas tumor size was a possible predictor. The most common complications after LITT are transient and permanent weakness, cerebral edema, hemorrhage, seizures, and hyponatremia. Conclusions. Although the current literature is limited by small sample sizes and primarily retrospective studies, LITT is a safe and effective treatment for brain lesions in the correct patient population.
关键词： brain tumor,brain metastasis,LITT
更新于2025-09-19 17:13:59
-
Laser interstitial thermal therapy for pediatric atypical teratoid/rhabdoid tumor: case report
摘要： Herein, the authors describe the successful use of laser interstitial thermal therapy (LITT) for management of metastatic craniospinal disease for biopsy-proven atypical teratoid/rhabdoid tumor in a 16-month-old boy presenting to their care. Specifically, LITT was administered to lesions of the right insula and left caudate. The patient tolerated 2 stages of LITT to the aforementioned lesions without complication and with evidence of radiographic improvement of lesions at the 2- and 6-month follow-up appointments. To the authors’ knowledge, this represents the first such published report of LITT for management of atypical teratoid/rhabdoid tumor.
关键词： laser interstitial thermal therapy,ATRT,atypical teratoid/rhabdoid tumor,pediatric brain tumor,LITT
更新于2025-09-19 17:13:59
-
Radical Laser Interstitial Thermal Therapy Ablation Volumes Increase Progression-Free Survival in Biopsy-Proven Radiation Necrosis
摘要： Radical Laser Interstitial Thermal Therapy Ablation Volumes Increase Progression-Free Survival in Biopsy-Proven Radiation Necrosis
关键词： oncology,brain tumor,radiation necrosis,brain metastasis,progression free survival,Laser interstitial thermal therapy,post-radiation treatment effects
更新于2025-09-16 10:30:52
-
Multiple Iterations of Magnetic Resonance-Guided Laser Interstitial Thermal Ablation of Brain Metastases: Single Surgeon's Experience and Review of the Literature
摘要： BACKGROUND: Prior treatment with magnetic resonance-guided, laser-induced thermal therapy (LITT) is widely assumed not to be a contraindication for further treatment of brain lesions, including further iterations of LITT. However, the safety and efficacy of repeat LITT treatments have never been formally investigated. OBJECTIVE: To evaluate treatment with multiple iterations of LITT. METHODS: All patients treated with LITT at least twice at our institution were included in the study. Outcomes and neurological examinations from before and after surgery were retrospectively examined from clinic notes. Perilesonal edema was determined at various timepoints using volumetric data derived from manual tracings of fluid-attenuated inversion recovery (FLAIR) enhancement on magnetic resonance imaging (MRI). Finally, a literature review of prior cases of repeat LITT was performed. RESULTS: A total of 9 patients underwent 18 treatments with LITT; all but 1 of whom were treated for metastatic brain lesions. One patient had a transient cerebrospinal fluid leak, whereas a second patient had a superficial wound infection, both of which resolved with standard medical care. The remaining 7 patients tolerated all LITT procedures without complication. Analysis of perilesional edema volume demonstrated a correlation with the amount of energy delivered during LITT. Literature review found 5 published papers describing 9 patients who underwent LITT more than once, the majority of whom tolerated repeat LITT well. CONCLUSION: LITT is a safe and promising treatment modality and may be used multiple times without issue. There appears to be an association between the amount of energy delivered during a LITT session and the degree of postoperative perilesional edema.
关键词： Brain tumor,Metastasis,Magnetic resonance laser-induced thermal therapy,Minimally invasive surgery,Tumor recurrence
更新于2025-09-12 10:27:22
-
Diagnostic value of radiolabeled amino acid PET for detection of pseudoprogression of brain tumor after treatment
摘要： The purpose of the current study was to investigate the diagnostic performance of radiolabeled amino acid PET for detection of pseudoprogression (PsP) of brain tumor after treatment through a systematic review and meta-analysis. Methods: The PubMed and EMBASE database, from the earliest available date of indexing through 15 February 2019, were searched for studies evaluating the diagnostic performance of radiolabeled amino acid PET for detection of PsP. We determined the sensitivities and specificities across studies, calculated positive and negative likelihood ratios, and constructed summary receiver operating characteristic (SROC) curves. Results: Across seven results from six studies (971 patients), the pooled sensitivity was 0.89 [95% confidence interval (CI): 0.82–0.94] without heterogeneity (I2 = 0.0) and a pooled specificity of 0.88 (95% CI: 0.76–0.94) without heterogeneity (I2=29.4). Likelihood ratio syntheses gave an overall positive likelihood ratio of 7.3 (95% CI: 3.6–14.7) and negative likelihood ratio of 0.12 (95% CI: 0.07–0.21). The pooled diagnostic odds ratio (DOR) was 60 (95% CI: 23–152). Hierarchical SROC curve indicates that the areas under the curve (AUC) was 0.92 (95% CI: 0.90–0.94). Conclusion: The current meta-analysis showed the good sensitivity and specificity of radiolabeled amino acid PET for detection of PsP of brain tumor after treatment. Also, the DOR was high and SROC curve showed high AUC value.
关键词： PET,diagnosis,amino acid,Pseudoprogression,brain tumor
更新于2025-09-12 10:27:22
-
The Role of Laser Interstitial Thermal Therapy in Surgical Neuro-Oncology: Series of 100 Consecutive Patients
摘要： BACKGROUND: Laser interstitial thermal therapy (LITT) is an adjuvant treatment for intracranial lesions that are treatment refractory or in deep or eloquent brain. Initial studies of LITT in surgical neuro-oncology are limited in size and follow-up. OBJECTIVE: To present our series of LITT in surgical neuro-oncology to better evaluate procedural safety and outcomes. METHODS: An exploratory cohort study of all patients receiving LITT for brain tumors by a single senior neurosurgeon at a single center between 2013 and 2018. Primary outcomes included extent of ablation (EOA), time to recurrence (TTR), local control at 1-yr follow-up, and overall survival (OS). Secondary outcomes included complication rate. Outcomes were compared by tumor subtype. Predictors of outcomes were identified. RESULTS: A total of 91 patients underwent 100 LITT procedures; 61% remain alive with 72% local control at median 7.2 mo follow-up. Median TTR and OS were 31.9 and 16.9 mo, respectively. For lesion subtypes, median TTR (months, not applicable [N/A] if <50% rate observed), local control rates at 1-yr follow-up, and median OS (months) were the following: dural-based lesions (n = 4, N/A, 75%, 20.7), metastases (n = 45, 55.9, 77.4%, 16.9), newly diagnosed glioblastoma (n = 11, 31.9, 83.3%, 32.3), recurrent glioblastoma (n = 14, 5.6, 24.3%, 7.3), radiation necrosis (n = 20, N/A, 67.2%, 16.4), and other lesions (n = 6, 12.3, 80%, 24.4). TTR differed by tumor subtype (P = .02, log-rank analysis). EOA predicted local control (P = .009, multivariate proportional hazards regression); EOA > 85% predicted longer TTR (P = .006, log-rank analysis). Complication rate was 4%. CONCLUSION: Our series of LITT in surgical neuro-oncology, 1 of the largest to date, further evidences its safety and outcomes profile.
关键词： Outcomes,Brain tumor,Laser,Metastasis,Treatment,Glioma
更新于2025-09-11 14:15:04
-
Preoperative Magnetic Resonance Imaging Based Predictive Modeling of Brain Tumor Laser Ablation
摘要： Glioblastoma (GBM) is the deadliest and most common primary brain cancer in adults. Brain tumor-initiating cells (BTICs) are a heterogeneous subset of stem-like, invasive cells that play a critical role in treatment failure and recurrence. Here, we propose a system to functionally characterize patient-derived BTICs to identify features that will guide assessment of therapeutics in a BTIC subpopulation-specific manner. We established and evaluated 5 BTIC populations based on (1) proliferation, (2) stemness, (3) migration, (4) tumorigenesis, (5) clinical characteristics, and (6) therapeutic sensitivity. Overall, in Vitro growth trends reflected in Vivo growth rates. However, a significant difference was found between tumor growth in male versus female mice in 3 BTIC lines (QNS108 P = .0011; QNS120 P < .0001; QNS 140 P < .0001). Differences in survival were observed, where BTICs derived from male and female patients produced faster morbidity in mice of the opposite sex (male derived QNS108 male vs female P = .0039; female derived QNS203 male vs female P = .029). QNS203, which was isolated from a tumor in contact with the anterior subventricular zone, decreased survival at a faster rate compared to other cell lines (n = 10 per line, 5 males/5 females, P < .0001). Stem-like properties of BTICs were assessed via differentiation marker expression, sphere-forming capacity, and detection of canonical marker CD133. Higher CD133 expression correlated with faster in Vitro doubling time and greater tumor burden. Histology reflected similar patient tumor features such as migration across the corpus callosum and cystic formation. BTICs revealed varying responses to therapies (TMZ, Radiation, TRAIL, BMP4) and varied competence to retroviral transduction. By studying the functional features of BTICs within our model of GBM heterogeneity, it was shown that several factors influenced tumorigenesis and survival. These included original tumor location, stemness, variation in therapeutic sensitivity, and a critical finding for the role of sex, an unexplored area for creating next-generation, sex-specific, and BTIC-specific therapeutics.
关键词： Brain tumor-initiating cells,Glioblastoma,Sex-specific therapeutics,BTICs,Therapeutic sensitivity
更新于2025-09-11 14:15:04