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Facile ultrasonic synthesized NH2-carbon quantum dots for ultrasensitive Co2+ ion detection and cell imaging
摘要： The amine decorated carbon quantum dots (NH2-CQDs) were synthesized through ultrasonic method from graphite rods derived CQDs and ammonia hydroxide and utilized as the sensing probes for cobalt (II) ions and nucleic acids. The sensing technique was investigated to be the fluorescence quenching effect, which demonstrated linear relationship between cobalt (II) ions concentration and the emission intensity deviation ratio in the concentration range of 50 nM to 40 μM with the detection limit of 12 nM. In brief, this sensitive and selective detection method was confirmed to demonstrate high potential in cobalt (II) ions detection in real samples and nucleic acid sensing in biological cells.
关键词： Nucleic acid sensing,Carbon quantum dots (CQDs),Cobalt sensor
更新于2025-11-19 16:56:42
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Photocatalytic activation of peroxymonosulfate by surface-tailored carbon quantum dots
摘要： In this study, carbon quantum dots (CQDs) were synthesized by a low-cost and scalable approach and the oxygen functional groups were fine-tuned by chemical post-treatment. It was found that the CQDs could be applied as visible-light-responsive photocatalysts for activation of peroxymonosulfate (PMS) and remediation of aqueous organic dyes. Phenylhydrazine modified CQDs (CQDs-PH) presented high efficiency for degradation of methylene blue due to selective removal of carboxylic groups and inhibited recombination of photogenerated electron-hole pairs. The effects of catalyst dosage, species and concentrations of dyes, and initial pH values on the photodegradation efficiency were systematically investigated and the alkaline condition facilitates the separation of photoinduced charge carriers and promotes the dye decoloration. The reactive oxygen species produced in the photocatalysis were identified by radical quenching tests and the mechanism was elucidated. Superoxide radicals were generated from PMS activation via electron transfer from CQDs and played the primary role for organic oxidation. In addition, photogenerated holes on the valence band of CQDs also participated in the dye decomposition.
关键词： peroxymonosulfate,superoxide radicals,Photocatalysis,oxygen groups,carbon quantum dots (CQDs)
更新于2025-09-19 17:13:59
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Bio-safety assessment of carbon quantum dots, N-doped and folic acid modified carbon quantum dots: A systemic comparison
摘要： The carbon quantum dots (CQDs) and their functionalized materials are promising in biomedical field because of their unique properties; meanwhile, a growing concern has been raised about the potential toxicity of these modified materials in biosystem. In this study, we synthesized original CQDs and two common functionalized CQDs including N-doped CQDs (NCQDs) and folic acid-modified CQDs (FA-CQDs), and compared the toxicity and biocompatibility with each other in vitro and in vivo. L929, C6 and normal cell MDCK were selected to detect the adverse reaction of these materials in vitro. No acute toxicity or obvious changes were noted from in vitro cytotoxicity studies with the dose of these CQD materials increasing to a high concentration at 1 mg/mL. Among these materials, the FA-CQDs show a much lower toxicity. Moreover, in vivo toxicity studies were performed on the nude mice for 15 days. The experimental animals in 10 or 15 mg/kg groups were similar with animals treated by phosphate buffer solution (PBS) after 15 days. The results of the multifarious biochemical parameters also suggest that the functionalized products of CQDs do not influence the biological indicators at feasible concentration. Our findings in vitro and in vivo through toxicity tests demonstrate that CQDs and their modified materials are safe for future biological applications.
关键词： Biodistribution,Functional materials,Biocompatibility,Fluorescence bioimaging,Carbon quantum dots (CQDs)
更新于2025-09-12 10:27:22