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Easy-to-operate fabrication of tapered glass capillaries for microdroplet generations
摘要： Tapered glass capillaries play an important role in micro droplets generation and related micro?uidic applications such as particle synthesis, digital PCR, microrectors. However, its controlled production poses a challenge. Speci?cally, there is di?culty controlling the tip sizes of capillaries with good repeatability at an a?ordable cost, which is critical to producing standard droplets for use by research groups. To produce tapered capillaries, micro needle geometries are ?rst pulled by commercial pipette puller, which yields a sharp tip (i.e. 1-3μm). Those tips need to be enlarged and standardized by post microfabrication. Although larger tips could be achieved by advanced pulling-forging, sanding-forging or breaking-forging methods, the uniformity and repeatability do not meet the requirements for mass production. In this paper, several easy-to-operate fabrication approaches, including mechanical and chemical fabrication methods, are studied. Chemical etching fabrication method shows good repeatability and robust control of dimensions. A capillary droplet micro?uidic device assembled by tapered glass capillaries fabricated by chemical etching method is also presented, which shows good performance for droplet generations. This non-labor intensive fabrication is straightforward and be readily adopted for industrial scale mass production.
关键词： glass capillary,micro fabrication,taper,droplet generation
更新于2025-09-23 15:22:29
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[IEEE 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII) - Berlin, Germany (2019.6.23-2019.6.27)] 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII) - Picoliter Droplet Generation for Fast Monitoring the Brain Chemistry with Scaled Silicon Nanodyalisis Probe
摘要： To monitor neurochemicals while minimizing brain damage, a microdialysis system is developed with fluidic channels scaled to 5 μm-radius to fit into 15x50 μm2 silicon neural probe. Droplet generation is utilized to halt Taylor dispersion to achieve high temporal resolution. To extend the stability region for monodisperse droplet generation in such a space-limited probe at ultra-low nL/min flow rates, we varied the T-junction angle, parameter that is typically omitted from consideration for larger channels. In a series of experiments, we found that increase of the T-junction angle increases the critical capillary number separating squeezing and regimes. With jetting segmentation optimized geometry, we demonstrated generation of monodisperse pL-volume droplets in silicon nanofluidic channels. Finite element analysis indicated that these effects are due to interplay between differential pressure and viscous shear forces.
关键词： Neurochemistry,MEMS,Droplet generation,Microdialysis,Implantable neural probe
更新于2025-09-11 14:15:04