- 标题
- 摘要
- 关键词
- 实验方案
- 产品
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Fluorescent Nanodiamonds || Color Centers in Diamond
摘要： In this chapter, we will discuss the key features of nanodiamonds that are relevant to the development of fluorescent nanodiamonds (FNDs) and their many uses in biotechnology and beyond. Up till now, we have surveyed nanotechnology in previous chapters starting with its historical development and focusing, in particular, on the nanocarbon materials. With a general introduction to nanodiamonds (Chapter 2), we have learned some methods commonly used to prepare man‐made diamonds and the fundamental properties shared by all diamonds and nanodiamonds alike. In this and the following two chapters, we are about to find out that nanodiamonds can glow (Chapter 3), support (Chapter 4), and is safe to use (Chapter 5). These unique features have made nanodiamonds a superior material for a fast‐growing list of applications at present time and in the coming future.
关键词： biotechnology,fluorescent nanodiamonds,diamond,nanodiamonds,color centers
更新于2025-09-23 15:21:01
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Fluorescent Nanodiamonds || Producing Fluorescent Nanodiamonds
摘要： Natural diamonds in colors are commonly known as fancies, or fancy color diamonds, in gemstone industries. They are rare, beautiful, and some even carry impressive price tags in the jewelry market. By comparison, micro‐ and nanoscale diamond powders are low in price, with or without colors and fluorescent or not. These powders have been used as abrasives for grinding and polishing purposes since ancient time, mainly because of their extraordinary hardness. Little or no attention has been paid over the centuries to other properties of nanodiamonds such as their innate biocompatibility and light‐emitting capability. The invention of fluorescent nanodiamond (FND) in 2005 has revolutionized the field, opening a new area of research and development with diamonds. Experiments with FNDs in the last decade have demonstrated various promising applications of surface‐functionalized FNDs in diversified fields, ranging from physics and chemistry to biology and medicine. It is worthy of noting that as originated from the discovery of Radium by Marie Sk?odowska Curie (Section 3.2), FNDs may very well be called Madame Curie’s gemstones, valued appropriately as a scientist’s best friend.
关键词： fluorescent nanodiamonds,magnetically modulated fluorescence,fluorescence lifetime,size reduction,FND,ion irradiation,H3 centers,nitrogen-vacancy centers,electron irradiation,NV centers
更新于2025-09-23 15:21:01
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Fluorescent Nanodiamonds || Cell Labeling and Fluorescence Imaging
摘要： Nanocarbons are a family consisting of fullerenes, carbon nanotubes, graphenes, nanodiamonds, and other variations. Fluorescent nanodiamonds (FNDs) joined the family in 2005. While receiving less attention than other members of the family, FNDs are gaining popularity as a novel nanoparticle platform for biomedical applications in recent years. An ideal biomedical nanoparticle platform should possess three functionalities: targeting, imaging, and therapeutic. Of course, the nanoparticles must be endowed with high biocompatibility and low cytotoxicity. As evident from all the discussions so far in this book, surface‐functionalized FND clearly meets all these requirements. Applying the platform to biomedical studies is expected to enhance our understanding of the pathophysiological basis of disease, open up more sophisticated diagnostic opportunities, and lead to improved therapies and treatments.
关键词： Imaging,Targeting,Fluorescent nanodiamonds,Nanocarbons,Therapeutic,Biomedical applications
更新于2025-09-23 15:21:01
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Fluorescent Nanodiamonds || Cell Tracking and Deep Tissue Imaging
摘要： Cell labeling, both specific and nonspecific, discussed in the previous chapter belongs in part to the field of cell therapy, defined as 'administration of live whole cells or maturation of a specific cell population in a patient for the treatment of a disease'. Cell therapy is an emerging field in the medical research as a promising treatment option for human injuries and diseases. While the first use of cells for therapeutic purposes can be traced to the nineteenth century, much is still lacking in our knowledge of the therapy, including the biodistribution, pharmacokinetics, and pharmacodynamics of transplanted human cells in vivo. Such knowledge is essential for detailed understanding of the cells' development, fate, and contribution to regenerating tissues prior to clinical trials.
关键词： cell tracking,cell therapy,fluorescent nanodiamonds,deep tissue imaging,nanotechnology
更新于2025-09-23 15:21:01