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Efficacy of propranolol and pingyangmycin, respectively, combined with pulsed dye laser on children with hemangioma
摘要： Clinical efficacy of propranolol and pingyangmycin, respectively, combined with pulsed dye laser in the treatment of children with hemangioma was analyzed, to provide a new therapeutic idea for their clinical treatment. A total of 120 children with hemangioma were selected into the study. Children treated with propranolol combined with pulsed dye laser were in group A, those treated with pingyangmycin combined with pulsed dye laser were in group B, and 60 healthy children were selected as control group (group C). Blood samples of children were taken before and after treatment for miR?4295 detection. The expression of miR?4295 was observed after treatment, and the total clinical remission rate and adverse reactions after treatment were compared between the two groups. The tumor volume of the two groups was significantly reduced after treatment, with statistically significant difference (P<0.05); miR?4295 expression was reduced in the two groups (P<0.05); adverse reactions in propranolol group were less than pingyangmycin group during treatment (P<0.05). Propranolol and pingyangmycin, respectively, combined with pulsed dye laser had ideal efficacy on hemangioma in children. Moreover, miR?4295 was highly expressed in children with hemangioma, and the expression level reduced after two methods of treatment. However, adverse reactions in propranolol group were less and its safety was higher.
关键词： pingyangmycin,miR?4295,children with hemangioma,pulsed dye laser
更新于2025-09-23 15:21:01
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Subretinal Fluid Optical Density and Spectral-Domain Optical Coherence Tomography Characteristics for the Diagnosis of Circumscribed Choroidal Hemangioma
摘要： Purpose: To investigate spectral domain-optical coherence tomography (SD-OCT) features of untreated circumscribed choroidal hemangioma (CCH), and the optical density (OD) of the associated subretinal fluid (SRF). Procedures: This international retrospective multicenter study conducted at 5 tertiary retina referral centers included 34 patients with symptomatic CCH imaged on SD-OCT. CCH surface, size, and overlying retinal changes and OD ratio (ODR) were evaluated. Results: The mean ODR of the SRF was 0.808 ± 0.287. Tumor base measured on ultrasound correlated significantly with the ODR (p = 0.012). ODR values in cases of CCH were similar to those of choroidal metastasis, but significantly lower than those of choroidal melanoma (p = 0.006). Thirty-two out of 34 cases (94%) presented with a regular smooth choroidal surface. OCT demonstrated SRF overlying the CCH in 29 eyes (85%). The presence of SRF correlated significantly with a larger basal tumor diameter (p = 0.035). OCT displayed sub- and intraretinal hyperreflective foci, correlating with both larger maximal retinal thickness overlying the tumor (p = 0.031) and the amount of SRF (p = 0.016) in 29 eyes (85%). Conclusion: CCH displays typical findings on SD-OCT. ODR is a new important tool in the differential diagnosis of choroidal tumors and should be considered for enhancing the accuracy of diagnosing CCH. This benefit is especially relevant for cases in which the presentation of CCH is atypical.
关键词： Optical density,Optical coherence tomography,Ocular tumors,Circumscribed choroidal hemangioma
更新于2025-09-23 15:21:01
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New technology for coagulation of dilated vessels using the combined effects of several modes of generation and wavelengths in one laser pulse for the treatment of pediatric hemangiomas: Open prospective study
摘要： An open, prospective, nonrandomized study of 122 children with infantile hemangiomas aged 1 to 24 months was conducted to evaluate the effectiveness and safety of treatment with multiline laser equipment using the Nd:YAP Q-Sw/KTP emitters with the combined use of two wavelengths of 1079/540 nm. The average age of the children was (6.3 ± 0.3) months, 22 of them were boys (18.0%) and 100 were girls (82.0%). An erythometry and ultrasound examination were performed to determine the depth of the neoplasm, to assess its blood flow, and the presence and diameter of the supply vessels. Studies of these indicators were conducted for patients before and after the treatment. Laser treatment was performed on 109 patients with 119 hemangiomas. A total of 81 superficial hemangiomas underwent a short course of laser therapy (2-5 procedures) and remaining patients with 38 combined hemangiomas received a long course of laser treatment, consisting of 6 to 10 procedures. Restoration of normal color, skin relief, and the absence of scars were noted in post-treatment sample on evaluation. After the course of treatment, erythometry readings corresponded to the values of normal skin and decreased to 110 to 80 cu. Ultrasound examination showed vascular formation and feed vessels were not visualized.
关键词： skin hemangiomas,Nd:YAP,vascular,infantile hemangioma,KTP laser,childhood hemangioma
更新于2025-09-23 15:19:57
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Management of oral vascular anomalies with diode laser: report of 2 clinical cases
摘要： Purpose This article reports the usefulness of a 980-nm diode laser (Simpler, Dr Smile) for the treatment of oral cavity vascular abnormalities. Introduction Vascular abnormalities are common vascular lesions characterized by elevated, usually, dome-shaped papules. These range in color from dark blue to dark purple and are seen more frequently in elderly patients. They often occur as single lesions on the lips, cheeks, and tongue. Although these lesions are usually asymptomatic, they can bleed if injured. Case report The first case is about a 42-year-old woman referred for evaluation of a facial and oral bluish lesion. Clinically, we diagnosed this extensive lesion as an acquired hemangioma. Under local anesthesia (Mepivacaine), we performed a photocoagulation of the lesion using a 980-nm diode laser (Dr Smile) in noncontact mode (2 mm of focal distance) with a 300-nm fiber, continues mode, 1.5 W power, during 1 min. The session was repeated 15 days later. After 6 weeks, wound healing was completed uneventfully. The second case is about a woman, aged 54, sent by a colleague for a purplish lesion on the inner side of the left cheek. Clinically, we diagnosed venous malformation. With the same diode (980 nm), we worked 2–3 mm away from the surface of the lesion, with a power of 4 W in continuous mode, under local anesthesia (Mepivacaine). The patient received only one session. The following controls at 10, 20, and 30 days showed the persistence of an ulceration which healed after 40 days. Conclusion The patients had no complications during the laser sessions, and their postoperative period was uneventful. We, therefore, concluded that the diode is an excellent therapeutic alternative in the treatment of oral cavity venous malformations.
关键词： Venous malformation,Photocoagulation,Vascular abnormality,Hemangioma,Diode laser
更新于2025-09-23 15:19:57
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Therapeutic effect of high‐frequency ultrasound‐assisted dye laser on hemangioma and its influence on serum HIF‐1α in patients
摘要： Background: To analyze the therapeutic effect of high‐frequency ultrasound (HFU)‐assisted dye laser on hemangioma patients and changes in serum hypoxia‐inducible factor‐1α (HIF‐1α). Methods: A total of 20 patients diagnosed with hemangioma in our hospital from January 2013 to March 2018 were selected, including 12 males and eight females. All patients were treated with HFU‐assisted dye laser. The site and type of hemangioma and age distribution of patients were collected, and changes in data and area of hemangioma and serum HIF‐1α before and after treatment were analyzed. Results: The vascular condition of hemangioma in all patients was significantly improved at 7, 14, and 30 days after treatment. Gray‐scale ultrasound displayed that the tumor area was reduced by more than 50%. After treatment, the serum HIF‐1α level declined obviously after treatment compared with that before treatment, showing a statistically significant difference (P < 0.05). Conclusion: HFU‐assisted dye laser can effectively reduce the tumor area, decrease the serum HIF‐1α level, and improve the prognosis in the treatment of hemangioma.
关键词： HFU,hemangioma,laser,HIF‐1α
更新于2025-09-19 17:13:59
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Residual Lesions After Pharmacological and Dye‐Laser Treatment of Infantile Hemangiomas: Critical Review of 432 Cases
摘要： Background and Objectives: Infantile hemangiomas (IHs) are the most common benign tumors in infanthood. Although they are often self‐limiting, management of IHs is still controversial because residual lesions may persist in some cases. The aim of this study is to report our experience with patients affected with IH and investigate the frequency of residual lesions in treated versus untreated patients. Study Design/Materials and Methods: This retrospective observational study enrolled patients with IHs evaluated over the past 10 years. Patients were managed with systemic or local pharmacotherapy, laser therapy, a combination of them, or with observation only. Results: A total of 432 patients were included: 71% received one or more therapies for IHs; 75.2% of untreated patients had at least one residual lesion compared with 41.4% of treated patients (P < 0.001). Patients treated with laser therapy or topical timolol had the lowest rate of residual lesions. Conclusions: This rather large case series suggests that IHs management with pharmacotherapy and especially laser therapy is associated with a lower number of residual lesions than observation only. Although propranolol can be very useful to avoid life‐threatening complications and severe tissue impairment, laser therapy and topical timolol are potential effective treatments to decrease the incidence of residual lesions, mostly associated with superficial IHs.
关键词： topical timolol,residual lesions,dye‐laser,Infantile Hemangioma,propranolol
更新于2025-09-12 10:27:22
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New Interpretation of Multimodality Fundus Imaging for Retinal Cavernous Hemangioma
摘要： Objective: The aim of this study was to investigate the multimodality imaging features of retinal cavernous hemangiomas (RCHs). Materials and Methods: The clinical data of three patients with RCH were reviewed and the imaging findings were analyzed. Results: The color photographs of the fundus showed bead-like vesicles in the retina. Some vesicles showed plasma erythrocyte separation—with plasma on the top and erythrocytes at the bottom—which was consistently detected as high spontaneous fluorescence on fundus fluorescence angiography. Other vesicles were surrounded by thick walls and fibrous tissue, showing high spontaneous fluorescence, although they did not show any changes on fluorescence angiography. Optical coherence tomography (OCT) could not discriminate the different characteristics of the vesicles, but could clearly discriminate the appearance of the vesicles and their location on the retina, as well as other structural features. Conclusions: Fundus color photography, fundus fluorescein angiography, and OCT can aid in acquiring a better understanding of the structural features of cavernous hemangioma and its relationship with retinal vessels.
关键词： fluorescein angiography,fundus color photography,Fundus autofluorescence,Retinal cavernous hemangioma,OCT
更新于2025-09-10 09:29:36
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A Case of Wyburn-Mason Syndrome with Facial Nevus Flammeus and the Associated Optical Coherence Tomography Findings
摘要： Purpose: To describe a case of Wyburn-Mason Syndrome, which is a rare phakomatosis, and its associated optical coherence tomography findings. Case summary: A 5-year-old boy was referred to our clinic for decreased vision in his right eye. He had nevus flammeus on his right forehead, upper eyelid, and cheek. His best corrected visual acuity was hand motion in the right eye, in which a relative afferent pupillary defect was noted. Fundus examination of the right eye showed marked dilation and tortuosity of retinal vessels, which could not be discriminated between arteries and veins on the posterior pole. Optical coherence tomography showed multiple large intraretinal vessels without involvement of the internal limiting membrane. Cerebral angiography revealed arteriovenous malformations (AVMs) and feeder vessels from the internal carotid artery to the ophthalmic artery, extending to the ethmoidal artery in the nasal cavity. Conclusions: Wyburn-Mason syndrome is a rare phakomatoses and shows unique retinal AVM. Misdiagnosis or undertreatment of Wyburn-Mason syndrome can lead to serious complications. Patients with facial nevus flammeus should undergo thorough ocular examinations to rule out this disorder. Optical coherence tomography is a useful method for understanding structural features of retinal vascular malformations in Wyburn-Mason syndrome.
关键词： Nevus flammeus,Arteriovenous malformation,Racemose hemangioma,Optical coherence tomography,Wyburn-Mason syndrome
更新于2025-09-09 09:28:46
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Gastric Hemangioma Treated with Argon Plasma Coagulation in a Newborn Infant
摘要： Gastric hemangioma in the neonatal period is a very rare cause of upper gastrointestinal bleeding. We present a case of hemangioma limited to the gastric cavity in a 10-day-old infant. A huge, erythematous mass with bleeding was observed on the lesser curvature side of the upper part of the stomach. Surgical resection was ruled out because the location of the lesion was too close to the gastroesophageal junction. Medical treatment with intravenous H2 blockers, octreotide, packed red blood cell infusions, local epinephrine injection at the lesion site, application of hemoclip, and gel-form embolization of the left gastric artery did not significantly alter the transfusion requirement. Hemostasis was achieved with endoscopic argon plasma coagulation (APC). After two sessions of APC, complete removal of the lesion was achieved. APC was a simple, safe and effective tool for hemostasis and the ablation of gastric hemangioma without significant complications.
关键词： Neonate,Hemangioma,Stomach,Argon plasma coagulation
更新于2025-09-04 15:30:14
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Elevated Choroidal Thickness and Central Serous Chorioretinopathy in the Fellow Eyes of Patients with Circumscribed Choroidal Hemangioma
摘要： Objective: To determine whether increased choroidal thickness (CT) is associated with circumscribed choroidal hemangioma (CCH) and whether patients with CCH are predisposed to central serous chorioretinopathy (CSCR). Methods: We performed a retrospective consecutive observational study of 15 fellow eyes of 15 patients who had CCH. A- and B-scan ultrasonography, fluorescein angiography (FA), and optical coherence tomography (OCT) findings were reviewed to confirm the diagnosis of CCH. Fellow eye CT was measured using enhanced depth imaging OCT. FA, indocyanine green angiography, and OCT images of fellow eyes were reviewed for signs of CSCR. Results: Mean subfoveal CT was significantly greater in the fellow eyes of patients with CCH than in age-matched normal eyes (p = 0.004). Three of 15 (20.0%) fellow eyes of CCH patients had retinal pigment epithelium disruptions and/or pigment epithelial detachments indicative of previous asymptomatic CSCR. Conclusion: In this pilot study, elevated CT was associated with a risk of developing CCH as well as CSCR in patients of varying ages. Patients diagnosed with CCH should be screened for CSCR in the fellow eye. Further exploration of this association may reveal useful clues about the biology of abnormally elevated choroidal hyperpermeability and its various clinical manifestations.
关键词： Serous chorioretinopathy,Choroidal hemangioma,Choroidal thickness,Contralateral eye
更新于2025-09-04 15:30:14