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2D resolution improvement via 1D scanning Space-Time Digital Holography (STDH) in Optofluidics
摘要： Space-Time Digital Holography (STDH) exploits the object motion to record the hologram in a hybrid space-time domain. This representation adds new capabilities to conventional DH, such as unlimited extension of the Field of View (FoV) and tunable phase shifting. Here we show that STDH is able to improve the spatial resolution as well. Differently from other super-resolution approaches, stitching between holograms or their spectra is no longer required. Moreover, we introduce a new STDH modality to record and process hybrid space-time representations. This allows improving resolution with one single object scan, paving the way to the use of STDH for superresolution imaging onboard Lab on a Chip devices.
关键词： Space-Time Digital Holography,STDH,Lab on a Chip,optofluidics,super-resolution
更新于2025-09-11 14:15:04
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Characterization and Integration of Terahertz Technology within Microfluidic Platforms
摘要： In this work, the prospects of integrating terahertz (THz) time-domain spectroscopy (TDS) within polymer-based microfluidic platforms are investigated. The work considers platforms based upon the polar polymers polyethylene terephthalate (PET), polycarbonate (PC), polymethyl-methacrylate (PMMA), polydimethylsiloxane (PDMS), and the nonpolar polymers fluorinated ethylene propylene (FEP), polystyrene (PS), high-density polyethylene (HDPE), and ultra-high-molecular-weight polyethylene (UHMWPE). The THz absorption coefficients for these polymers are measured. Two microfluidic platforms are then designed, fabricated, and tested, with one being based upon PET, as a representative high-loss polar polymer, and one being based upon UHMWPE, as a representative low-loss nonpolar polymer. It is shown that the UHMWPE microfluidic platform yields reliable measurements of THz absorption coefficients up to a frequency of 1.75 THz, in contrast to the PET microfluidic platform, which functions only up to 1.38 THz. The distinction seen here is attributed to the differing levels of THz absorption and the manifestation of differing f for the systems. Such findings can play an important role in the future integration of THz technology and polymer-based microfluidic systems.
关键词： lab-on-a-chip,THz time-domain spectroscopy,microfluidics,polymer absorption
更新于2025-09-10 09:29:36
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From chip-in-a-lab to lab-on-a-chip: a portable Coulter counter using a modular platform
摘要： The field of microfluidics has been struggling to obtain widespread market penetration. In order to overcome this struggle, a standardized and modular platform is introduced and applied. By providing easy-to-fabricate modular building blocks which are compatible with mass manufacturing, we decrease the gap from lab-to-fab. These standardized blocks are used in combination with an application-specific fluidic circuit board. On this board, electrical and fluidic connections are demonstrated by implementing an alternating current Coulter counter. This multipurpose building block is reusable in many applications. In this study, it identifies and counts 6 and 11 μm beads. The system is kept in a credit card-sized footprint, as a result of in-house-developed electronics and standardized building blocks. We believe that this easy-to-fabricate, credit card-sized, modular, and standardized prototype brings us closer to clinical and veterinary applications, because it provides an essential stepping stone to fully integrated point-of-care devices.
关键词： modular platform,point-of-care devices,lab-on-a-chip,microfluidics,Coulter counter
更新于2025-09-10 09:29:36
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Modeling and Analysis of an Opto-Fluidic Sensor for Lab-on-a-Chip Applications
摘要： In this work modeling and analysis of an integrated opto-?uidic sensor, with a focus on achievement of single mode optical con?nement and continuous ?ow of microparticles in the micro?uidic channel for lab-on-a-chip (LOC) sensing application is presented. This sensor consists of integrated optical waveguides, micro?uidic channel among other integrated optical components. A continuous ?ow of microparticles in a narrow ?uidic channel is achieved by maintaining the two sealed chambers at different temperatures and by maintaining a constant pressure of 1 Pa at the centroid of narrow ?uidic channel geometry. The analysis of silicon on insulator (SOI) integrated optical waveguide at an infrared wavelength of 1550 nm for single mode sensing operation is presented. The optical loss is found to be 5.7 × 10?4 dB/cm with an effective index of 2.3. The model presented in this work can be effectively used to detect the nature of microparticles and continuous monitoring of pathological parameters for sensing applications.
关键词： micro?uidic channel,SOI waveguide,lab-on-a-chip,?uid ?ow rate,microparticles
更新于2025-09-09 09:28:46
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Numerical Demonstration of In-Tube Liquid-Column Migration Driven by Photoisomerization
摘要： Droplet manipulation by light-induced isomerization was numerically demonstrated and investigated regarding the driving mechanism. Such a non-invasive manipulation of a droplet in a microchannel can be realized, for example, by the use of watery solution of photoresponsive surfactant that exhibits the isomerization. Due to variable fluid properties between the cis and trans isomers, one-side light irradiation on a liquid column in a tube would lead to some kind of imbalance between the two ends of the liquid column and then drive droplet migration. The present numerical simulations of air–liquid two-phase flow and its scalar transport of the isomer, considering the variable static contact angle, agreed quantitatively with the experimental results in terms of the migration speed. This fact supports the contention that the droplet migration is more likely to be driven by an imbalance in the wettability, or the contact angle. The migration speed was found to be less dependent on the liquid-column length, but proportional to the tube diameter.
关键词： photochemical reaction,non-invasive control,wettability,surface tension,microfluidics,computational fluid dynamics,lab-on-a-chip,droplet manipulation,two-phase flow,photoresponsible surfactant
更新于2025-09-09 09:28:46