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Reflectance spectra characteristics from an SPR grating fabricated by nano-imprint lithography technique for biochemical nanosensor applications
摘要： In this paper, we report our research work on developing a Surface Plasmon Resonance (SPR) element with sub-micron (hundreds of nanometers) periodicity grating structure. This grating structure was fabricated by using a simple nano-imprint lithography technique from an organically siloxane polymers, which was then covered by nanometer thin gold layer. The formed grating structure was a very well defined square-shaped periodic structure. The measured reflectance spectra indicate the SPR wave excitation on this grating structure. For comparison, the simulations of reflectance spectra have been also carried out by using Rigorous Coupled-Wave Analysis (RCWA) method. The experimental results are in very good agreement with the simulation results.
关键词： biochemical nanosensor,SPR,grating,nano-imprint lithography,reflectance spectra
更新于2025-09-10 09:29:36
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A multichannel Au nanosensor for visual and pattern inspection of fatty acids
摘要： Fatty acids (FAs) are important dietary sources of fuel for animals and structural components for cells. The number, position and configuration of olefins in the alkyl chains play important roles in the impacts of FAs on human health. Currently, structural profiling of FAs in edible oils and fats is an important issue in nutrition industries and food safety. Due to the lack of distinct functional groups, it is extremely difficult to discriminate FAs with structural difference by facile and in situ sensing methods. A few chemosensors have been developed for shape selective sensing of FAs, but their capability and performance were still limited. Herein, for the first time, we proposed a multichannel Au nanosensor for visual and pattern-generating inspection of FAs based on the highly selective binding ability of Ag+ to olefinic bonds and Ag+ regulable color variation of Au nanoparticles. As a result, the nanosensor showed good selectivity for five FAs with subtle structural difference as low as 5 nM. By further deriving three channel signals in respect of color and color depth, a signature-like signal pattern could be generated by principal component analysis for each FAs and even different FAs mixtures such as edible oils. Hence, structural variation of FAs in edible hot pot oils with heat treatment was successfully monitored by this Au nanosensor in time course. This sensor holds great promise in point-of-care inspection of edible oils and fats.
关键词： Au nanosensor,Colorimetric sensing,Pattern recognition,Edible oils,Fatty acids
更新于2025-09-09 09:28:46
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Copolymer template etching for Au nanoparticles self-assembly
摘要： In this paper, we report a study on self-assembly of Au colloids assisted by polystyrene (PS)-polymethyl methacrylate (PMMA) block copolymer templates. Etching PMMA cylindrical domains of PS-PMMA thin films provides large-scale arrays of holes in which 12nm Au colloids may fall into. We demonstrate that the holes’ functionalisation with aminosilanes favours the deposition of the Au colloids into the holes. The extinction spectroscopy measurements demonstrate that the Au NPs which are self-assembled using this process do not present any aggregation. Such a process should pave the way for designing plasmonic devices like optical nanosensors.
关键词： optical nanosensor,localised surface plasmon resonance,copolymer template,metallic nanoparticles,self-assembly
更新于2025-09-09 09:28:46
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One-Dimensional Nanostructures: Microfluidic-Based Synthesis, Alignment and Integration towards Functional Sensing Devices
摘要： Micro?uidic-based synthesis of one-dimensional (1D) nanostructures offers tremendous advantages over bulk approaches e.g., the laminar ?ow, reduced sample consumption and control of self-assembly of nanostructures. In addition to the synthesis, the integration of 1D nanomaterials into micro?uidic chips can enable the development of diverse functional microdevices. 1D nanomaterials have been used in applications such as catalysts, electronic instrumentation and sensors for physical parameters or chemical compounds and biomolecules and hence, can be considered as building blocks. Here, we outline and critically discuss promising strategies for micro?uidic-assisted synthesis, alignment and various chemical and biochemical applications of 1D nanostructures. In particular, the use of 1D nanostructures for sensing chemical/biological compounds are reviewed.
关键词： alignment,micro?uidics,nanosensor,one-dimensional nanostructures,continuous ?ow
更新于2025-09-09 09:28:46
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Aluminum(III) triggered aggregation-induced emission of glutathione-capped copper nanoclusters as a fluorescent probe for creatinine
摘要： Glutathione-capped copper nanoclusters (CuNCs) are presented that display aggregation-induced emission (AIE). This feature was exploited for selective and sensitive quantification of creatinine (CRN) which is an important diagnostic parameter. In the presence of Al3+ ions, such CuNCs rapidly aggregate, and this induces enhanced a red emission. The AIE nature of CuNCs was proven via TEM and fluorimetry. On addition of CRN, the coordination between CRN and Al3+ ions led to the quenching of fluorescence due to weakening the AIE. The best fluorescence intensity was measured at excitation/emission peaks of 360/585 nm. Quenched fluorescence intensity showed a linear dependence on the concentrations of CRN in the range of 2.5–34 μgL?1 with a detection limit of 0.63 μgL?1. The sensing mechanism of probe for CRN detection is discussed. The probe was applied to the determination of CRN in spiked human serum samples and gave satisfactory results.
关键词： Nanosensor,Renal biomarker,Serum analysis,Fluorescent nanomaterials,Metal nanoclusters,Nanoprobe,Paired t-test,Fluorometry,Real sample analysis
更新于2025-09-04 15:30:14
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Polydiacetylene/triblock copolymer/surfactant nanoblend: A simple and rapid method for the colorimetric screening of enrofloxacin residue
摘要： Colorimetric nanosensors formed of polydiacetylene (PDA), triblock copolymer (L64 or F68), and sodium dodecyl sulfate (SDS), so-called nanoblends, were developed to detect enrofloxacin (ENRO) in aqueous media. The nanosensors show hydrodynamic diameter ranging from 234.2 ± 3.5 to 801.6 ± 17.8 nm for SDS concentrations of 13.0–21.0 mM, respectively. The lowest limit of detection was 0.054 μM, which is five times smaller than the maximum limit allowed by the European Union. The response surfaces showed that both the SDS and ENRO concentrations influenced the colorimetric response (p<0.05), and kinetic rate of colorimetric transition (RCT). SDS concentration between 11.0 and 14.0 mM in the nanoblend yielded the most sensitive nanosensors for detecting ENRO. When L64 was replaced by F68, the colorimetric response of the nanoblends was similar, but PDA/F68/SDS showed a slower RCT than PDA/L64/SDS. The developed nanosensor is a sensitive and simple device for the fast detection of ENRO.
关键词： polydiacetylene,Nanosensor,sodium dodecyl sulfate,antibiotic,triblock copolymer
更新于2025-09-04 15:30:14