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Fluorescent Nanosensors Based on Colloidal Quantum Dots for the Determination of Reduced Glutathione
摘要： A ? uorescent nanosensor based on colloidal quantum dots CdSe/ZnS modi? ed with mercaptoacetic acid to determine reduced glutathione, a non-protein compound that plays an important role in protection against oxidative stress, is developed. Sample preparation protocols that allow determination of reduced glutathione in a wide range of concentrations are presented. Dependence of the ? uorescence intensity of the system on the incubation time for a number of concentrations of reduced glutathione was measured. The possibility of using the proposed nanosensor for reliable and sensitive determination of reduced glutathione in the concentration range from 10 to 1000 μM is con? rmed. The results can be used for quantitative determination of reduced glutathione in physiological media, which is of considerable interest for medical diagnostics.
关键词： quantum dots,nanoparticles,optical nanosensors,? uorescence,reduced glutathione,disease markers,medical diagnostics
更新于2025-09-11 14:15:04
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[IEEE 2018 IEEE Photonics Conference (IPC) - Reston, VA, USA (2018.9.30-2018.10.4)] 2018 IEEE Photonics Conference (IPC) - Cavity Optomechanical Photothermal Sensors
摘要： We experimentally demonstrate a cavity optomechanical sensor that is actuated with gradient optical forces. The sensor can detect incident radiation via absorption and resulting photothermally-induced frequency shifts of the nanomechanical oscillator. Analysis suggests that nanostrain sensitivity and fJ-level energy detection are possible.
关键词： Photothermal effects,Strain measurement,Nanoelectromechanical systems,Nanosensors,Optical waveguides,Nanophotonics
更新于2025-09-09 09:28:46
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Chemometric Approaches for Developing Infrared Nanosensors to Image Anthracyclines
摘要： Generation, identification, and validation of optical probes to image molecular targets in a biological milieu remains a challenge. Synthetic molecular recognition approaches leveraging the intrinsic near-infrared fluorescence of single-walled carbon nanotubes is a promising approach for long-term biochemical imaging in tissues. However, generation of nanosensors for selective imaging of molecular targets requires a heuristic approach. Here, we present a chemometric platform for rapidly screening libraries of candidate single-walled carbon nanotube nanosensors against biochemical analytes to quantify fluorescence response to small molecules including vitamins, neurotransmitters, and chemotherapeutics. We further show this approach can be leveraged to identify biochemical analytes that selectively modulate the intrinsic near-infrared fluorescence of candidate nanosensors. Chemometric analysis thus enables identification of nanosensor-analyte ‘hits’ and also nanosensor fluorescence signaling modalities such as wavelength-shifts that are optimal for translation to biological imaging. Through this approach, we identify and characterize a nanosensor for the chemotherapeutic anthracycline doxorubicin, which provides an up to 17 nm fluorescence red-shift and exhibits an 8 μM limit of detection, compatible with peak circulatory concentrations of doxorubicin common in therapeutic administration. We demonstrate selectivity of this nanosensor over dacarbazine, a chemotherapeutic commonly co-injected with DOX. Lastly, we demonstrate nanosensor tissue compatibility for imaging of doxorubicin in muscle tissue by incorporating nanosensors into the mouse hindlimb and measuring nanosensor response to exogenous DOX administration. Our results motivate chemometric approaches to nanosensor discovery for chronic imaging of drug partitioning into tissues and towards real-time monitoring of drug accumulation.
关键词： fluorescence response,single-walled carbon nanotubes,infrared nanosensors,biological imaging,doxorubicin,chemometric approaches,anthracyclines
更新于2025-09-09 09:28:46
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Recent Advances in Ferroelectric Nanosensors: Toward Sensitive Detection of Gas, Mechanothermal Signals, and Radiation
摘要： A spontaneous polarization that occurs below the Curie temperature is characteristic for ferroelectric materials. This polarization is sensitive to many external conditions such as an electric field, mechanical deformation, temperature, and chemical and biological factors. Therefore, bulk ferroelectric materials have been used for decades in sensors and actuators. Recently, special attention has been paid to ferroelectric nanostructures that represent better sensing properties than their bulk counterparts. This paper presents a comprehensive survey of applications of nanoferroelectrics in different types of sensors, e.g., gas sensors and piezoelectric, pyroelectric, and piezoresistive sensors of mechanothermal signals, as well as photodetectors, ionizing radiation detectors, and biosensors. The recent achievements and challenges in these fields are summarized. This review also outlines the prospects for future development of sensors based on nanosized ferroelectrics.
关键词： gas detection,ferroelectric,nanosensors,mechanothermal signals,radiation detection,biosensors
更新于2025-09-09 09:28:46