- 标题
- 摘要
- 关键词
- 实验方案
- 产品
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A novel near-infrared light responsive 4D printed nanoarchitecture with dynamically and remotely controllable transformation
摘要： Four-dimensional (4D) printing is an emerging and highly innovative additive manufacturing process by which to fabricate pre-designed, self-assembly structures with the ability to transform over time. However, one of the critical challenges of 4D printing is the lack of advanced 4D printing systems that not only meet all the essential requirements of shape change but also possess smart, dynamic capabilities to spatiotemporally and instantly control the shape-transformation process. Here, we present a facile 4D printing platform which incorporates nanomaterials into the conventional stimuli-responsive polymer, allowing the 4D printed object to achieve a dynamic and remote controlled, on-time and position shape transformation. A proof-of-concept 4D printed brain model was created using near-infrared light (NIR) responsive nanocomposite to evaluate the capacity for controllable 4D transformation, and the feasibility of photothermal stimulation for modulating neural stem cell behaviors. This novel 4D printing strategy can not only be used to create dynamic 3D patterned biological structures that can spatiotemporally control their shapes or behaviors of transformation under a human benign stimulus (NIR), but can also provide a potential method for building complex self-morphing objects for widespread applications.
关键词： brain,4D printing,dynamically and remotely controllable,neural stem cell,near-infrared light responsive,graphene
更新于2025-11-21 11:08:12
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Near-infrared-light-triggered photoelectrochemical biosensor for detection of alpha-fetoprotein based on upconversion nanophosphors
摘要： A novel photoelectrochemical (PEC) biosensor based on hybrids of NaYF4:Yb, Tm， zinc oxide (ZnO) and cadmium sulfide (CdS) was constructed to detect alpha-fetoprotein (AFP), which possesses the advantages of low background noise and non-damage to the biological substance. Herein, we prepared NaYF4:Yb,Tm/ZnO/CdS composite film electrode by pulsed laser deposition. The selected materials of ZnO and CdS can make full use of the upconversion luminescence (~360nm, ~480nm) of NaYF4:Yb,Tm nanophosphors under 980nm laser excitation. Meanwhile, an effective matching of energy levels between the conduction bands of CdS and ZnO can prompt photoelectrochemical performance of the electrode. The biosensor shows ultrasensitive detection of AFP with a wide linear range from 0.01 ng mL-1 to 200 ng mL-1 and a low detection limit of 5 pg mL-1. Therefore, the proposed PEC biosensor based on upconversion nanophosphors is potentially attractive for achieving excellent photoelectrochemical biosensor for detection of other cancer markers in clinical analysis.
关键词： photoelectrochemical,pulsed laser deposition,upconversion luminescence,near-infrared light-triggered biosensor
更新于2025-11-14 15:27:09
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NIR-Responsive Copolymer Upconversion Nanocomposites for Triggered Drug Release in Vitro and in Vivo
摘要： Light has several advantages as the stimulus for triggered drug release. Currently, the applications of phototriggered drug-release devices (PDDs) are largely limited by two factors: the limited tissue penetration and detrimental effects caused by excitation light (ultraviolet or visible light). To address this disadvantage, this study developed nanocomposites based on upconversion nanoparticles (UC), which could convert near-infrared light to ultraviolet-visible light and trigger drug release. By loading UC and doxorubicin (DOX) into photo-responsive copolymer PEG-NMAB-PLA (PNP), near-infrared responsive copolymer upconversion nanocomposites (PNP-DOX-UC) was constructed. We proved that PNP-DOX-UC showed the fast release and strong cytotoxicity under near infrared irradiation in vitro. The therapeutic efficacy study indicated that PNP-DOX-UC+hv had the enhanced antitumor efficiency. In the study, UC becoming an internal ultraviolet-visible light source for near infrared excitation developes an applicable and efficient approach to meet the requirements for UV/Vis excitation, which is a major disadvantage in photosensitive materials developed for pharmaceutical and biomedical applications.
关键词： Near-infrared light,Photo-responsive,Nanocomposites,Copolymer,Triggered drug release,Upconversion Nanoparticle
更新于2025-09-23 15:23:52
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Near-infrared light controlled fluorogenic labeling of glycoengineered sialic acids <i>in vivo</i> with upconverting photoclick nanoprobe
摘要： Near-infrared light controlled fluorogenic labeling of glycoengineered sialic acids in vivo with upconverting photoclick nanoprobe. Sialic acid serves as an important determinant for profiling cell activities in diverse biological and pathological processes. The precise control of sialic acid labeling to visualize its biological pathways under endogenous conditions is significant but still challenging due to the lack of reliable methods. Herein, we developed an effective strategy to spatiotemporally label the sialic acids with a near-infrared (NIR) light activated upconverting nanoprobe (Tz-UCNP). With this photoclickable nanoprobe and a stable N-alkene-D-mannosamine (Ac4ManNIPFA), metabolically synthesized alkene sialic acids on the cell surface were labeled and imaged in real time through fluorogenic cycloaddition. More importantly, we achieved spatially selective visualization of sialic acids in specific tumor tissues of the mice under NIR light activation in a spatially controlled manner. This in situ controllable labeling strategy thus enables the metabolic labeling of specific sialic acids in complex biological systems.
关键词： fluorogenic labeling,sialic acids,Near-infrared light,upconverting nanoprobe,photoclick chemistry
更新于2025-09-23 15:21:01
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Drug Delivery System Using Photothermal Effect of Gold Nanorods
摘要： Gold nanorods have absorption bands in the near-infrared region. The absorbed light energy is converted into heat by gold nanorods. Therefore, drug delivery systems that can be controlled by the heat produced by near-infrared light irradiation will be constructed. First, we modified gold nanorods with double-stranded DNA. That is, release of single stranded DNA is induced by the produced heat from the gold nanorods. We also constructed a controlled release system of PEG chain mediated by retro Diels-Alder reaction induced by the photothermal effect. Next, we designed transdermal protein delivery system enhanced by the photothermal effect. We first casted gold nanorods, acting as a heating device in response to near-infrared light irradiation, onto the skin surface. After applying an aqueous solution of ovalbumin to the skin, the skin was irradiated by near-infrared laser light. The irradiation increased the skin temperature resulting in an efficient translocation of ovalbumin into the skin. Thus, the controlled-release systems and enhanced transdermal protein delivery system triggered by near-infrared light irradiation will be further expanded to development of functional drug delivery system.
关键词： photothermal effect,gold nanorods,transdermal protein delivery,drug delivery system,near-infrared light
更新于2025-09-23 15:21:01
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Neara??Infrared Lighta??Induced Sequential Shape Recovery and Separation of Assembled Temperature Memory Polymer Microparticles
摘要： Light-induced, shape-changing polymeric microparticles have many applications. Here, the near-infrared (NIR)-light-triggered sequential recovery and separation of assembled large and small polymer microparticles using cross-linked blends of poly(ethylene-vinyl acetate) and trans-polyisoprene as temperature memory polymers as well as two NaYF4 based up-conversion nanoparticles (UCPs) to provide luminescent and photothermal effects are reported. Under irradiation of NIR light with a low light power density, small particles assembled onto the compressed large one recover first due to the low switching temperature (Tsw) arising from the temperature–memory effect. The small particles can separate from the underlying large particle in flowing aqueous media. The recovery of the large particle occurs at a high power density. Two UCPs of NaYF4: 20Yb, 0.2Tm, 5Gd and NaYF4: 18Yb, 2Er, 5Gd facilitate the detection of small and large microparticles via providing blue and green light emissions, respectively. This work can expand the applications of light-induced shape-changing polymer microparticles in the biomedical field, controlled catalysis, microfluidic devices, and so on.
关键词： up-conversion nanoparticles,temperature-memory effect,polymer microparticles,near-infrared light
更新于2025-09-23 15:19:57
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Self-Powered Filterless Narrow-Band pa??n Heterojunction Photodetector for Low Background Limited Near-Infrared Image Sensor Application
摘要： Photonic detection with narrow spectrum selectivity is very important to eliminate the signal from obtrusive light, which can improve the anti-interference ability of the infrared imaging system. While self-driving effect inherent to p-n junction is very attractive in optic-electronic integration, the application of p-n junction in narrow-band photodetector is limited by the usual broad absorption range. In this work, a self-powered filterless narrowband near-infrared photodetector based on CuGaTe2/silicon p-n junction was reported. The as-fabricated photodetector exhibited typical narrow-band response which shall be ascribed to the slightly smaller bandgap of Si than CuGaTe2 and the restricted photocurrent generation region in the p-n heterojunction by optimizing CuGaTe2 thickness. It is observed that when the thickness of CuGaTe2 film is 143 nm, the device exhibits a response peak centered around 1050 nm with a full-width at half-maximum of ~118 nm. Further device analysis reveals a specific detectivity of ~1012 Jones and a responsivity of 114 mA/W under 1064 nm illumination at zero bias. It was also found that image system based on the narrowband CuGaTe2/Si photodetector showed high noise immunity for its spectral selective characteristics.
关键词： p-n heterojunction,near infrared light,image sensing,spectral selectivity,narrow band photodetector
更新于2025-09-23 15:19:57
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Near-infrared absorption enhancement for perovskite solar cells via the rear grating design
摘要： Optical management and design is one of the most effective methods to unlock the full potential of photocurrent density and power conversion efficiency for perovskite solar cells (PSCs). However, the common-used optical designs are still limited by the near-infrared response. Here, we proposed an effective optical structure in PSCs by texturing the rear-side perovskite layer with a rectangular grating to promote the optical response in the near-infrared region. Through the comprehensive numerical simulations, the new design under the optimized structural configuration shows an improved photocurrent density, i.e., from 22.75 (flat structure) to 23.72? mA/cm2. We confirm that the optical absorption enhancement occurs at the near-infrared region by the wavelength-dependent absorption and reflection spectra. Besides, the light-trapping mechanism was clarified by the comprehensive analysis of the electric field distributions. Moreover, PSCs having the rear-grating design demonstrate the superior optical performance compared to that of flat design in the varied incident angles. Our simulation results displayed in this study provide an easy scheme to promote the optical absorption in near-infrared region.
关键词： Near-infrared light,Rear grating,Perovskite solar cells,Optical absorption
更新于2025-09-23 15:19:57
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Gold nanoparticles doped metal-organic frameworks as near-infrared light-enhanced cascade nanozyme against hypoxic tumors
摘要： We report gold nanoparticles (AuNPs) doped iron-based metal-organic frameworks (GIM) which displays near-infrared light (NIR)-enhanced cascade nanozyme against hypoxic tumors. Due to the strong protein adsorption-induced surface passivation, AuNPs suffer from the loss of glucose oxidase (GOx) activity. However, GIM could protect the GOx-like activity of AuNPs with the satisfactory shield capability. In addition, GIM exhibited excellent photothermal conversion ability and unique NIR light-enhanced GOx-like activity, which could efficiently increase the endogenous H2O2 production. Meanwhile, as the produced H2O2 is converted by GIM into O2 and highly toxic (cid:1668)OH. Thus, GIM-catalyzed cascade reactions with NIR light irradiation not only offer the O2 but also promote the reactive oxygen species (ROS) generation at tumor sites. The produced O2 could be further applied to AuNPs catalytic oxidation of glucose and relieve hypoxic condition of tumor microenvironment (TME). As a proof-of-concept study, GIM demonstrates the admirable tumor ablation under NIR irradiation in vivo.
关键词： near-infrared light,metal-organic frameworks,reactive oxygen species,nanozyme,gold nanoparticles
更新于2025-09-23 15:19:57
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Neara??Infrareda??toa??Visible Photon Upconversion by Introducing an Sa??T Absorption Sensitizer into a Metala??Organic Framework
摘要： Triplet-triplet annihilation-based photon upconversion (TTA-UC) of near-infrared (NIR) light to visible light in the solid-state remains as a great challenge due to the sensitizer aggregation that impedes the efficient triplet energy transfer. Herein, we successfully introduce a molecular sensitizer exhibiting direct singlet-to-triplet (S–T) absorption into a new emitter-based metal-organic framework (MOF) to achieve an efficient triplet sensitization and a NIR-to-visible TTA-UC in the solid-state.
关键词： photon upconversion,near-infrared light,metal-organic framework,singlet-to-triplet absorption,triplet-triplet annihilation
更新于2025-09-23 15:19:57