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Nucleus-targeted organoiridium-albumin conjugate for photoactivated cancer therapy
摘要： A novel organoiridium-albumin bioconjugate (Ir1-HSA) was synthesized via reaction of a pendant maleimide ligand with human serum albumin. The phosphorescence of Ir1-HSA was enhanced significantly compared to the parent complex Ir1. The long phosphorescence lifetime and high 1O2 quantum yield of Ir1-HSA are highly favourable properties for photodynamic therapy. Ir1-HSA mainly accumulated in the nucleus of living cancer cells and showed remarkable photocytotoxicity against a range of cancer cell lines and tumor spheroids (light IC50; 0.8-5 μM, photo-cytotoxicity index PI = 40-60) while remaining non-toxic to normal cells and normal cell spheroids, even after photo-irradiation. This nucleus-targeting organoiridium-albumin is a strong candidate photosensitizer for anticancer photodynamic therapy.
关键词： Photodynamic therapy,Photosensitizer,Albumin,Organoiridium
更新于2025-09-23 15:19:57
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Nucleus‐targeted organoiridium‐albumin conjugate for photoactivated cancer therapy
摘要： A novel organoiridium-albumin bioconjugate (Ir1-HSA) was synthesized via reaction of a pendant maleimide ligand with human serum albumin. The phosphorescence of Ir1-HSA was enhanced significantly compared to parent complex Ir1. The long phosphorescence lifetime and high 1O2 quantum yield of Ir1-HSA are highly favourable properties for photodynamic therapy. Ir1-HSA mainly accumulated in the nucleus of living cancer cells and showed remarkable photocytotoxicity against a range of cancer cell lines and tumor spheroids (light IC50; 0.8-5 μM, photo-cytotoxicity index PI = 40-60) while remaining non-toxic to normal cells and normal cell spheroids, even after photo-irradiation. This nucleus-targeting organoiridium-albumin is a strong candidate photosensitizer for anticancer photodynamic therapy.
关键词： Albumin,Organoiridium,Photosensitizer,Photodynamic therapy
更新于2025-09-04 15:30:14