- 标题
- 摘要
- 关键词
- 实验方案
- 产品
-
Investigation of minor elemental species within tablets using in situ depth profiling via laser-induced breakdown spectroscopy hyperspectral imaging
摘要： Laser-induced breakdown spectroscopy (LIBS) hyperspectral imaging allows for the determination of two-dimensional and three-dimensional spatial distributions of elemental species throughout complex samples. In this work, LIBS hyperspectral imaging was utilized to investigate minor elemental species within tablets. Representative LIBS spectra were initially collected on four complex, heterogeneous tablets, showing high concentrations of Ti in the tablet coating, with low and variable abundance of Na, Mg, and K. Principal component analysis revealed distinct resolution of the four tablets due to differences in Na, Mg, and K. Using two-dimensional LIBS hyperspectral imaging, spatial distributions of Na, Mg, and K within defined x and y regions of the tablet coating were generated. Subsequent three-dimensional LIBS hyperspectral imaging further elucidated the full x, y, and z spatial distributions of these minor elemental species within the tablet surface, tablet coating, and tablet core. As such, in situ depth profiling of the minor elemental species within each tablet was accomplished. Quantification of the homogeneity and uniformity of each tablet was determined. To our knowledge, this is the first report of multivariate analysis, LIBS, and LIBS hyperspectral imaging being utilized for the determination of both 2D and 3D spatial distributions of minor elemental species, along with quantification of tablet homogeneity, within tablets.
关键词： Chemical imaging,Laser-induced breakdown spectroscopy,Chemometrics,Pharmaceutical analysis,Atomic spectroscopy
更新于2025-09-23 15:19:57
-
Wavelet Transform-Based UV Spectroscopy for Pharmaceutical Analysis
摘要： In research and development laboratories, chemical or pharmaceutical analysis has been carried out by evaluating sample signals obtained from instruments. However, the qualitative and quantitative determination based on raw signals may not be always possible due to sample complexity. In such cases, there is a need for powerful signal processing methodologies that can effectively process raw signals to get correct results. Wavelet transform is one of the most indispensable and popular signal processing methods currently used for noise removal, background correction, differentiation, data smoothing and filtering, data compression and separation of overlapping signals etc. This review article describes the theoretical aspects of wavelet transform (i.e., discrete, continuous and fractional) and its characteristic applications in UV spectroscopic analysis of pharmaceuticals.
关键词： UV spectroscopy,continuous wavelet transform,discrete wavelet transform,pharmaceutical analysis,fractional wavelet transform
更新于2025-09-10 09:29:36
-
Determination of iodide based on dynamic gas extraction and colorimetric detection by paper modified with silver triangular nanoplates
摘要： This paper reports on a new method for sensitive and selective determination of iodide based on dynamic gas extraction with air flow and digital colorimetric detection using paper modified with silver triangular nanoplates (AgTNPs). Iodide is oxidized in a sample by Fe(III) to produce molecular iodine which is extracted in air flow and transferred to a sensitive AgTNPs-containing paper layer. Interaction of AgTNPs with iodine results in optical changes which can be monitored by ordinary scanner. The high selectivity of dynamic gas extraction to volatile compounds ensures successful analysis of such samples as cranberry and kelp with no sample pretreatment, and due to the sensitivity of AgTNPs good analytical performance can be achieved. The limit of detection of iodide was found to be of 0.01 mg L?1 and the determination range of 0.03–0.3 mg L?1. The method can be easily adapted to simultaneous determination of iodide/iodine and iodide/chloride in the same sample.
关键词： Scanner,Silver triangular nanoplates,Colorimetry,Dynamic gas extraction,Plant and pharmaceutical analysis,Iodide
更新于2025-09-10 09:29:36