- 标题
- 摘要
- 关键词
- 实验方案
- 产品
-
FR - Utilidad del láser de colorante pulsado en el lupus eritematoso cutáneo
摘要： El lupus eritematoso cutáneo (LEC) es una enfermedad autoinmune heterogénea con manifestaciones clínicas muy variables, desde lesiones cutáneas aisladas hasta una afectación sistémica grave. Existen, por tanto, diferentes subtipos con características clínicas, histológicas y analíticas bien definidas, siendo constante en todos ellos la afectación cutánea1. Atendiendo a la guía de tratamiento del LEC elaborada por el European Dermatology Forum en 2017 llama la atención que el tratamiento con láser de lesiones activas del LEC estaría desaconsejado. En dicho manuscrito se especifica que este podría ser usado como un tratamiento complementario solo en caso de ser administrado por un dermatólogo acreditado y en lesiones muy seleccionadas (telangiectasias)2. Esta recomendación contrasta de forma notable con lo descrito en la literatura hasta el momento. Desde que en 1986 Henderson et al. aplicaran con éxito láser CO2 a una paciente con lupus eritematoso discoide desfigurante, han sido múltiples los autores que han publicado casos tratados de forma satisfactoria con estos dispositivos3. Este láser junto con el láser argón mejoraban las lesiones cutáneas de los pacientes a expensas de efectos secundarios indeseados4. En contraposición, el láser de colorante pulsado (LCP), el más utilizado para el tratamiento del LEC, ha demostrado unos excelentes resultados (mejorías entre el 60-88%) con mínimos efectos secundarios (dolor, alteraciones de la pigmentación). Este láser permite tratar no solo las telangiectasias que exhiben estos pacientes, sino también el componente eritemato-edematoso con mejoría clínica, histológica y de la sintomatología asociada. Ha sido empleado con éxito en pacientes con lupus eritematoso crónico (discoide, tumidus) y subagudo, ofreciendo buenos resultados tanto en lesiones recalcitrantes que no responden a tratamientos tópicos y sistémicos, como en lesiones agudas, minimizando el riesgo de cicatrices secundarias5. Otras fuentes de luz como el láser Nd:YAG y la luz pulsada intensa han demostrado de forma puntual ser útiles en esta enfermedad, no obstante la evidencia aun es escasa. La seguridad del tratamiento con LCP en pacientes con lupus ha sido un tema ampliamente debatido. Este láser, con longitud de onda de 595 nm, se encuentra fuera del espectro ultravioleta de radiación, el cual es responsable de la fotosensibilidad de los pacientes con lupus. Además, el riesgo de inducir nuevas lesiones por un efecto Koebner no ha sido constatado hasta el momento. El mecanismo por el cual el LCP resulta efectivo no está del todo claro. La hipótesis que formulan la mayoría de autores se basa en una destrucción selectiva de la microvasculatura de las lesiones del LEC, lo cual ocasionaría una reducción del ambiente inflamatorio y la consecuente mejoría clínica e histológica6. En ocasiones los pacientes con LEC reciben altas dosis de fármacos inmunosupresores (tópicos y sistémicos) con respuestas poco satisfactorias y efectos secundarios nada desde?ables. Resulta importante que los dermatólogos conozcamos esta alternativa terapéutica pese a no estar estandarizada en las guías clínicas o algoritmos, dado su potencial y bajo perfil de efectos secundarios. De igual modo serían necesarios futuros estudios sobre la utilidad del LCP en el LEC, con el objetivo de poder ofrecer este tratamiento con un grado de recomendación apropiado.
关键词： Cutaneous lupus erythematosus,Discoid lupus,Subacute lupus,Therapeutics,Tumidus lupus,Pulsed dye laser
更新于2025-09-23 15:23:52
-
Efficacy of propranolol and pingyangmycin, respectively, combined with pulsed dye laser on children with hemangioma
摘要： Clinical efficacy of propranolol and pingyangmycin, respectively, combined with pulsed dye laser in the treatment of children with hemangioma was analyzed, to provide a new therapeutic idea for their clinical treatment. A total of 120 children with hemangioma were selected into the study. Children treated with propranolol combined with pulsed dye laser were in group A, those treated with pingyangmycin combined with pulsed dye laser were in group B, and 60 healthy children were selected as control group (group C). Blood samples of children were taken before and after treatment for miR?4295 detection. The expression of miR?4295 was observed after treatment, and the total clinical remission rate and adverse reactions after treatment were compared between the two groups. The tumor volume of the two groups was significantly reduced after treatment, with statistically significant difference (P<0.05); miR?4295 expression was reduced in the two groups (P<0.05); adverse reactions in propranolol group were less than pingyangmycin group during treatment (P<0.05). Propranolol and pingyangmycin, respectively, combined with pulsed dye laser had ideal efficacy on hemangioma in children. Moreover, miR?4295 was highly expressed in children with hemangioma, and the expression level reduced after two methods of treatment. However, adverse reactions in propranolol group were less and its safety was higher.
关键词： pingyangmycin,miR?4295,children with hemangioma,pulsed dye laser
更新于2025-09-23 15:21:01
-
Combined pulsed dye laser and systemic retinoids for the treatment of hypertrophic resistant warts among organ transplant patients
摘要： In this retrospective cohort study, we aimed to evaluate the efficacy and safety of a combined regimen of PDL and systemic retinoids in the treatment of recalcitrant warts among OTR.
关键词： Organ transplant patients,Pulsed dye laser,Systemic retinoids,Hypertrophic resistant warts
更新于2025-09-23 15:21:01
-
The clinical and electron microscopic evaluation of the impact of pulsed dye laser techniques on solar lentigines (randomized clinical trial)
摘要： Background: Solar lentigines are skin lesions manifested by benign dark pigmentation causing a cosmetic problem in many patients. Several treatment modalities used for the management of solar lentigines. Side effects and rates of recurrence may be associated with them. Objective: Treating solar lentigines with two different techniques of pulsed dye laser and evaluation of the results both clinically and via the examination of ultrastructural changes by electron microscopy. Patients and methods: This study was conducted on twenty-two subjects with solar lentigines and having Fitzpatrick III-IV skin types, was managed by the use of pulsed dye laser after enrolling them into two groups. Group I (one stacked pulsed dye laser was used) and Group II (treated by stacked pulsed dye laser in two sessions, one month apart). At baseline and six months after treatment, two punch biopsies with a diameter of 2mm were taken from all patients. All taken biopsies were prepared for light and electron microscopic examinations. Results: Both pulsed dye laser techniques induced significant better clinical and histological outcomes. No one demonstrated any postoperative complications such as post-inflammatory hyperpigmentation and scarring. Conclusion: The two techniques of pulsed dye laser are efficient for solar lentigines treatment.
关键词： Pulsed Dye laser,ultrastuctural study,Solar lentigines,Electron Microscope
更新于2025-09-23 15:19:57
-
Retrospective study of photodynamic therapy for pulsed dye lasera??resistant porta??wine stains
摘要： Pulsed dye laser-resistant port-wine stains present a therapeutic challenge. The aim of this study was to evaluate the efficacy and safety of photodynamic therapy for treating these lesions. A total of 67 patients with pulsed dye laser-resistant cervicofacial port-wine stains were retrospectively assessed after undergoing photodynamic therapy mediated with a combination of hemoporfin and 532-nm light. For objective evaluation of photodynamic therapy efficacy, first, the colorimetric changes in the port-wine stain lesions were evaluated according to the L*a*b* color coordinate system, then the values of color changes (DE) and blanching rate were calculated. For subjective evaluation of improvement, photographs taken before and after photodynamic therapy were evaluated by three independent assessors blindly. Patient satisfaction was also used as a factor in the subjective evaluation. Adverse events were recorded after treatment. The median DE decreased significantly from the pretreatment value of 13.42 to 9.90 at the 2-month follow up (P < 0.001). The median blanching rate of port-wine stains was 28.04% after an average of 1.21 sessions of photodynamic therapy. Based on the overall visual assessment, 46.2% patients showed excellent or good levels of improvement (>50% color blanching). Adverse events were minimal, transient and self-limiting. In conclusion, photodynamic therapy serves as an alternative means to treat pulsed dye laser-resistant port-wine stains.
关键词： pulsed dye laser,pulsed dye laser resistance,treatment efficacy,photodynamic therapy,port-wine stain
更新于2025-09-19 17:13:59
-
Short pulse intense pulsed light versus pulsed dye laser for the treatment of facial redness
摘要： Treating diffuse facial redness with an intense pulsed light (IPL) source usually requires multiple sessions and may not achieve complete clearance. The 595 nm pulsed dye laser (PDL) enjoys a good reputation for reducing facial redness with non-purpuric settings. The objective of this study was to compare facial redness reduction using these two devices. After establishing the lowest light dose able to achieve transient purpura for the same pulse width of 1,5 ms with each technology, right and left sides of the face were randomly assigned for each type of treatment. There were two treatment sessions 4 weeks apart and the final evaluation was performed 8 weeks after thesecond treatment. Four blinded experi-enced dermatologists analyzed pre and post-treatment photographs, which demonstrated an average of 60% improvement on the segment treated with the IPL as opposed to 45% on the other segment. Pain level was described as mild and the procedure was well tolerated for both types of treatment. In this study we showed that short-pulsed intense pulsed light and PDL are similar in decreasing facial redness when non-purpuric low fluence settings are used. The IPL was faster and did not have consumables.
关键词： Pulsed dye laser,rosacea,diffuse redness,intense Pulsed Light,facial erythema
更新于2025-09-19 17:13:59
-
Pulsed dye laser alone versus its combination with topical ivermectin 1% in treatment of Rosacea: a randomized comparative study
摘要： Background While the aetiology of rosacea is multifactorial, it is not surprising that treatment has been controversial. Pulsed dye laser (PDL) has been successfully used to treat vascular components of rosacea. Ivermectin 1% cream is an emerging treatment. Objective To provide a comprehensive clinical and dermatoscopic comparative study between the efficacy and safety of pulsed dye laser alone versus its combination with topical ivermectin 1% in the treatment of rosacea. Materials and methods Thirty Patients were randomly divided into two groups. Group A (n=15) treated with 585 nm PDL, and group B (n=15) treated with 585 nm PDL and topical ivermectin 1% cream. All patients received four laser treatments with a 4-week interval. The efficacy of treatment was assessed by photographs and dermoscopic photomicrographs at baseline and 3 months after the final treatment. The patient’s level of satisfaction was also recorded. Results At the 3-month follow-up, group B induced better clinical improvement than group A. However, this difference was not significant. No serious adverse events were observed in either treatment group. Conclusion This study supports the efficacy of PDL treatment for patients with rosacea. PDL could be more effective when combined with ivermectin 1% cream.
关键词： Rosacea,ivermectin,pulsed dye laser
更新于2025-09-19 17:13:59
-
Immediate post‐irradiation dermoscopic vascular changes versus purpura as a therapeutic endpoint in pulsed‐dye laser treatment of port wine stains
摘要： Pulsed-dye laser (PDL) is the treatment of choice for port wine stain (PWS), and the development of purpura is considered a therapeutic endpoint. Changes in PWS vasculature observed by dermoscopy immediately after laser irradiation have been suggested to predict the minimal effective fluence. The current study aimed at comparing these changes with purpura as a therapeutic endpoint. Fifty-six PWS patients, randomized into two groups, received five monthly PDL sessions (595 nm and 10 mm spot size). At the first visit, patients received multiple gradually increasing test irradiations. Patients in the first group were treated with the lowest dose that resulted in 24-hr-lasting purpura, while patients in the second group were treated with the lowest dose that resulted in vessel disappearance observed by dermoscope. No statistically significant differences were observed between the two groups (the dermoscopic and the purpuric) regarding mean average improvement (42.4 and 37.32%, respectively, p = .32), grade of improvement (p = .44), and the rate of side effects (0 and 13.79%, respectively, p = .13). In conclusion, the immediate post-irradiation vessel disappearance (detected by dermoscope) is comparable, in safety and efficacy, to purpura as a therapeutic endpoint and maybe more time-saving and more accepted cosmetically.
关键词： pulsed-dye laser,port wine stain,dermoscopy
更新于2025-09-19 17:13:59
-
A retrospective analysis for facial telangiectasia treatment using pulsed dye laser and intense pulsed light configured with different wavelength bands
摘要： Background: Facial telangiectasia is one of the common skin vascular lesions characterized by dilated cutaneous vasculatures. The variety of diameters and difference in depths of lesional blood vessels are the major challenges for effective treatments for Facial telangiectasia. Aims: To compare the efficacy and safety profiles of pulsed dye laser (PDL, 595 nm) with intense pulsed light (IPL) configured by three different wavelength bands in the treatment for facial telangiectasia in Asian populations. Patients/Methods: A retrospective analysis of hospital records and review on photographs were performed for those subjects with facial telangiectasia (n = 160) who were treated in our department from January 2017 to January 2019. Patients were received two sessions of one of the four following laser treatments: PDL (595 nm, n = 38), IPL with M22 vascular filter (530‐650 nm and 900‐1200 nm, n = 39), M22 560 (560‐1200 nm, n = 42), and M22 590 (590‐1200 nm, n = 41). Results: The patients in all the four groups showed an overall and significant improvement of indexes of lesional severity and subjective discomfort as well as improvement score of facial telangiectasia after treatment as compared to baseline. In addition, PDL (595 nm) and IPL with vascular filter (530‐650 nm and 900‐1200 nm) treatments showed significantly better indexes of lesional severity, subjective discomfort, and improvement score of facial telangiectasia as compared with other two treatments. Conclusion: Light devices with various wavelength ranges showed different efficacies of treatment for facial telangiectasia, among which PDL (595 nm) and IPL with M22 vascular filter (530‐650 nm and 900‐1200 nm) had similar and the best clinical efficacy as compared to IPL with other wavelength bands.
关键词： pulsed dye laser,intense pulse light,facial telangiectasia,efficacy,retrospective analysis
更新于2025-09-19 17:13:59
-
Harper's Textbook of Pediatric Dermatology || Laser Therapy
摘要： The pulsed dye laser has revolutionized the treatment of vascular anomalies. More recently, the multiplex laser, a combination of pulsed dye and Nd:YAG, has been shown to be beneficial for recalcitrant port wine stains and other conditions. In addition to their use in treating port wine stains, lasers have also an important role in treating a number of childhood pigmentary disorders. These are primarily congenital naevi such as café‐au‐lait macules, naevus of Ito and some blue lesions. Laser treatment is based on selective thermal destruction or damage to a targeted chromophore located in the skin, either that of blood, melanin or tissue water. Lasers have been shown to successfully treat vascular and pigmented lesions and also remove unwanted hair. They can also be used to remove verrucous lesions such as angiofibromas and epidermal naevi through vaporization.
关键词： pulsed dye laser,vascular anomalies,verrucous lesions,port wine stains,hair removal,selective photothermolysis,pigmentary disorders
更新于2025-09-16 10:30:52