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The clinical and electron microscopic evaluation of the impact of pulsed dye laser techniques on solar lentigines (randomized clinical trial)
摘要： Background: Solar lentigines are skin lesions manifested by benign dark pigmentation causing a cosmetic problem in many patients. Several treatment modalities used for the management of solar lentigines. Side effects and rates of recurrence may be associated with them. Objective: Treating solar lentigines with two different techniques of pulsed dye laser and evaluation of the results both clinically and via the examination of ultrastructural changes by electron microscopy. Patients and methods: This study was conducted on twenty-two subjects with solar lentigines and having Fitzpatrick III-IV skin types, was managed by the use of pulsed dye laser after enrolling them into two groups. Group I (one stacked pulsed dye laser was used) and Group II (treated by stacked pulsed dye laser in two sessions, one month apart). At baseline and six months after treatment, two punch biopsies with a diameter of 2mm were taken from all patients. All taken biopsies were prepared for light and electron microscopic examinations. Results: Both pulsed dye laser techniques induced significant better clinical and histological outcomes. No one demonstrated any postoperative complications such as post-inflammatory hyperpigmentation and scarring. Conclusion: The two techniques of pulsed dye laser are efficient for solar lentigines treatment.
关键词： Pulsed Dye laser,ultrastuctural study,Solar lentigines,Electron Microscope
更新于2025-09-23 15:19:57
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Retrospective photographic review of nontattoo indications treated by picosecond laser
摘要： Background: Picosecond (PS) lasers were approved by the US FDA in 2012 after being shown to remove tattoos with more success and fewer treatments compared with traditional methods. PS lasers were shown to be versatile, indicated for the treatment of lentigines, café-au-lait macules (CALMs), and acne scars and skin rejuvenation. Objective: We report our experience treating our patients for different indications using a PS laser. Methods: We performed a retrospective chart and photographic review of all patients seen between 2016 and 2018 that were treated in our centers with a PS laser for nontattoo indications. Clinical outcomes were evaluated using side-by-side comparisons of the clinical photographs by two blinded, independent physicians using a visual analog scale consisting of six levels of treatment response. Results: A total of 233 patients were studied. Most sought treatment for solar lentigo (27%) and skin rejuvenation (14%). Epidermal nevi exhibited the greatest improvement with treatment, while acne scarring demonstrated the least. Only 24% of patients experienced noteworthy, transient adverse effects. Conclusion: Picosecond lasers were efficacious and safe for a variety of indications. They were effective in treating epidermal nevi and pigmented lesions, such as Lentigines and CALMs.
关键词： aesthetic improvement,epidermal nevus,picosecond laser,laser treatment,solar lentigines
更新于2025-09-19 17:13:59