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Automatic thyroid nodule recognition and diagnosis in ultrasound imaging with the YOLOv2 neural network
摘要： Background: In this study, images of 2450 benign thyroid nodules and 2557 malignant thyroid nodules were collected and labeled, and an automatic image recognition and diagnosis system was established by deep learning using the YOLOv2 neural network. The performance of the system in the diagnosis of thyroid nodules was evaluated, and the application value of artificial intelligence in clinical practice was investigated. Methods: The ultrasound images of 276 patients were retrospectively selected. The diagnoses of the radiologists were determined according to the Thyroid Imaging Reporting and Data System; the images were automatically recognized and diagnosed by the established artificial intelligence system. Pathological diagnosis was the gold standard for the final diagnosis. The performances of the established system and the radiologists in diagnosing the benign and malignant thyroid nodules were compared. Results: The artificial intelligence diagnosis system correctly identified the lesion area, with an area under the receiver operating characteristic (ROC) curve of 0.902, which is higher than that of the radiologists (0.859). This finding indicates a higher diagnostic accuracy (p = 0.0434). The sensitivity, positive predictive value, negative predictive value, and accuracy of the artificial intelligence diagnosis system for the diagnosis of malignant thyroid nodules were 90.5%, 95.22%, 80.99%, and 90.31%, respectively, and the performance did not significantly differ from that of the radiologists (p > 0.05). The artificial intelligence diagnosis system had a higher specificity (89.91% vs 77.98%, p = 0.026). Conclusions: Compared with the performance of experienced radiologists, the artificial intelligence system has comparable sensitivity and accuracy for the diagnosis of malignant thyroid nodules and better diagnostic ability for benign thyroid nodules. As an auxiliary tool, this artificial intelligence diagnosis system can provide radiologists with sufficient assistance in the diagnosis of benign and malignant thyroid nodules.
关键词： Thyroid nodules,Ultrasound,Artificial intelligence,Computer-aided diagnosis systems,YOLOv2 neural network
更新于2025-09-23 15:22:29
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[IEEE 2018 20th International Conference on Transparent Optical Networks (ICTON) - Bucharest (2018.7.1-2018.7.5)] 2018 20th International Conference on Transparent Optical Networks (ICTON) - Changes in the Collagen Structure of Thyroid Nodule Capsules Determined by Polarization-Resolved Second Harmonic Generation Microscopy
摘要： Thyroid carcinomas represent a challenging problem as their differentiation from the much more frequent benign pathologies can be sometimes difficult. Automatic diagnostic approaches that can differentiate between malignant and benign thyroid nodules would be of great benefit for addressing thyroid pathologies. In this study we have used polarization-resolved second harmonic generation microscopy to investigate collagen organization in the fibrillar capsules surrounding human thyroid nodules. We demonstrate that imaging the collagen capsules at different laser beam polarization angles and fitting the second harmonic generation intensity with a theoretical curve can yield information on the nonzero components of the second order susceptibility tensor and the orientation of the collagen fibres. We have used this approach to differentiate between capsules surrounding the thyroid follicular adenoma and papillary carcinoma nodules. These results indicate that polarization-resolved second harmonic generation microscopy can provide additional information about the collagenous capsule surrounding thyroid nodules, which may complement intensity-based quantitative second harmonic generation microscopy and eventually traditional histopathologic examination.
关键词： second harmonic generation,thyroid nodules,collagen
更新于2025-09-23 15:22:29
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Laser Ablation versus Radiofrequency Ablation for benign non-functioning thyroid nodules: Six-month results of a randomised, parallel, open-label, trial (LARA trial)
摘要： Background: No direct prospective studies comparing laser ablation (LA) and radiofrequency ablation (RFA) for debulking benign non‐functioning thyroid nodules (BNTNs) exist. We aimed to compare the efficacy and safety of both techniques in patients with solid or predominantly solid BNTN. Methods. This six‐month, single‐use, randomized open label parallel trial compared the following primary endpoints between the RFA and LA groups six months after treatment: (1) nodule volume reduction expressed as a percentage of nodule volume at baseline; (2) proportion of nodules with more than 50 % reduction (successful rate). We enrolled subjects with a solitary BNTN or dominant nodule characterized by pressure symptoms/cosmetic problems or patients without symptoms who experienced a volume increase >20% in one year. Nodules underwent core needle biopsy (CNB) for diagnosis. Patients were randomly assigned (1:1) to receive LA or RFA. Safety was assessed in all randomly assigned participants. Results: Sixty patients were randomly assigned to receive either RFA or LA (1:1) between January 2016 and November 2018. Both groups were similar in basal nodule volume, thyroid function, histology, symptoms/cosmetic score, and procedure time. At six months, the nodule volume reduction was 64.3% (95% confidence interval 57.5 ‐ 71.2%) in the RFA group and 53.2% (47.2 – 95.2%; p = 0.02) in the LA group. This effect was also confirmed in the linear regression model adjusted for age, baseline volume, and proportion of cellular component (LA vs RFA percent change Delta= ‐12?8, p=0?02). No significant difference was observed in success rate 6‐month after treatment (RFA vs LA: 86?7% vs 66?7%, p=0?13) or in thyrotropin level between the groups. Although improved, no significant difference was observed between RFA and LA for compressive symptoms (RFA: 2.13 vs 3.9, p<0?001; LA: 2.4 vs 3.87, p<0?001) and cosmetic score (RFA: 1?65 vs 2?2, p<0?001; LA: 1?85 vs 2?2, p<0?001). The adverse event rates (local pain, dysphonia, thyrotoxicosis, fever, hematoma) were 37% (n=11) and 43% (n=13) for RFA and LA, respectively, with no requirement for hospitalization. Conclusion: While the success rate was similar in the RFA and LA groups, RFA achieved a significantly larger nodule volume reduction at six months.
关键词： Radiofrequency ablation,Laser ablation,Benign non‐functioning thyroid nodules,Thyroid nodules,Volume reduction
更新于2025-09-23 15:19:57
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Single‐Fiber Laser Ablation in Treating Selected Metastatic Lymph Nodes of Papillary Thyroid Carcinoma and Benign Cold Thyroid Nodules—Preliminary Results
摘要： To evaluate the feasibility and efficacy of single‐fiber laser ablation (LA) under ultrasound guidance and appropriate ablation modes in the treatment of selected metastatic lymph nodes of papillary thyroid carcinoma (PTC) and benign cold thyroid nodules. A total of 18 patients (consisting of 8 patients with 18 metastatic lymph nodes of PTC and 10 patients with 10 benign cold thyroid nodules) each underwent one session of single‐fiber LA under ultrasound guidance. On the basis of the sizes of the nodules, the ablation modes were chosen accordingly. The single‐dot ablation mode was used in the nodules with three orthogonal diameters measuring no greater than 10 mm in diameter, with a dot, a level and an insertion. The double‐dots overlapping ablation mode was used in the nodules with the largest diameters measuring greater than 10 mm (in which the nodules measured no more than 15 mm in diameter and with the other two perpendicular diameters measuring no greater than 10 mm in diameter) with two dots, a level and two insertions. The multiple levels and dots overlapping ablation mode was used in the nodules with the three orthogonal diameters all measuring larger than 10 mm, with multiple dots, levels and insertions. After 12 months of follow‐up in the treated nodules of the metastatic lymph nodes of PTC and benign cold thyroid nodules, the mean baseline volumes decreased from 0.29 ± 0.12 to 0.03 ± 0.03 ml and 3.85 ± 0.64 to 1.1 ± 0.37 ml, respectively, and the mean volume reduction ratios (VRRs), which was calculated as {[(initial volume ?final volume) × 100%]/initial volume}, were 90.3 ± 7.6% and 72 ± 5.8%, respectively. There were six ablative zones that completely disappeared, whereas the ablative zones that still existed presented as scar‐like areas or small hyperechoic areas that were compatible with scar tissue among the 18 malignant nodules at the last follow‐up. Single‐fiber LA under ultrasound guidance, with the appropriate ablation modes, is feasible and effective for the treatment of selected metastatic lymph nodes of PTC and benign cold thyroid nodules. This study suggests that single‐fiber LA may be applied to selected cases with appropriate ablation modes.
关键词： metastatic lymph nodes,ultrasound guidance,papillary thyroid carcinoma,benign cold thyroid nodules,single‐fiber laser ablation
更新于2025-09-19 17:13:59