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Self-assembly of porphyrin-grafted lipid into nanoparticles encapsulating doxorubicin for synergistic chemo-photodynamic therapy and fluorescence imaging
摘要： The limited clinical efficacy of monotherapies in the clinic has urged the development of novel combination platforms. Taking advantage of light-triggered photodynamic treatment combined together with the controlled release of nanomedicine, it has been possible to treat cancer without eliciting any adverse effects. However, the challenges imposed by limited drug loading capacity and complex synthesis process of organic nanoparticles (NPs) have seriously impeded advances in chemo-photodynamic combination therapy. In this experiment, we utilize our previously synthesized porphyrin-grafted lipid (PGL) NPs to load highly effective chemotherapeutic drug, doxorubicin (DOX) for synergistic chemo-photodynamic therapy.
关键词： photodynamic therapy,doxorubicin,theranostics,chemotherapy,porphyrin
更新于2025-09-23 15:21:21
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Semiconducting Langmuir-Blodgett Films of Porphyrin Paddle-Wheel Frameworks for Photoelectric Conversion
摘要： Understanding the photocurrent transportation within porphyrin-containing metal-organic frameworks (PMOFs) will be a critical step for applying these materials in light-harvesting molecular devices in the future. Two copper porphyrin paddle-wheel frameworks (Cu-PPFs) were employed to study the influence of metal ions coordinated into the porphyrin ligands on conductivity and photoelectron transfer capability. To compare the electronic and optical properties of both materials, we prepared an ultra-thin film of each PPF via a Langmuir-Blodgett method. The resulting films exhibited uniform morphology and single-crystalline domains, in addition to photoelectric conversion capabilities. We confirmed both Cu-PPFs have semiconducting properties with an optical bandgap around 2.7 eV. The current density generated by both Cu-PPFs were studied through a mercury drop junction approach. We observed a slightly higher conductivity from the Cu-PPF film consisting of metalloporphyrins than the one without copper doping in the porphyrin centers. In addition, the copper ions coordinated porphyrins were found to be more favorable for facilitating photo-induced electron transfer from the Cu-PPF film to a conductive glass substrate. This work presents a new approach of combining thin film fabrication and electro-heterojunction measurement to study electron transfer within an ultra-thin film.
关键词： Metal-Organic Framework (MOF),2D Material,Langmuir-Blodgett Film,Self-Assembly,Semiconductor,Porphyrin Thin Film,Photoelectric Conversion
更新于2025-09-23 15:21:21
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Crown-Porphyrin Ligand for Optical Sensors Development
摘要： A novel porphyrin ligand, Zn(II)TPP-BPI-crown (ZnPC), functionalized with two dibenzo-crown-ether moieties was synthesized and tested as cation-sensitive ionophore. Fluorescence studies on ligand sensitivity towards a number of different metal cations (Na+, K+, Li+, Ca2+, Mg2+, Co2+, Cd2+, Pb2+, Cu2+, Zn2+ and NH4+) were carried out first in solution and then inside polymeric membrane optodes. Emission light signal was sufficiently brilliant to be captured by a low-cost computer webcam, while a commercial blue-light LED served as monochromic excitation light source. The influence on the ZnPC optode response of the lipophilic sites functionalization was investigated. The visibly (naked eye) observed color change of sensing material from green to red demonstrated the suitability of the ZnPC-based optodes to perform fast monitoring of Cu(II) ions in the concentration range between 6.6 × 10?7 and 2.4 × 10?2 mol/L with a low detection limit (estimated by s/n = 3 method) of 0.3 mg/L, which is lower than WHO guideline value of 2 mg/L.
关键词： chemical optical sensor,novel Zn(II)-porphyrin ligand functionalized with two dibenzo-crown-ether moieties,naked eye detection of Cu(II) ions
更新于2025-09-23 15:21:01
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Syntheses of Chalcone-Type Chlorophyll Derivatives Possessing a Bacteriochlorin, Chlorin, or Porphyrin <i>π</i> -System and Their Optical Properties
摘要： C3-(Trans-arylethenyl)carbonylated chlorophyll derivatives possessing a bacteriochlorin or chlorin π-system were synthesized by cross-aldol (Claisen-Schmidt) condensation of methyl pyrobacteriopheophorbide-a or 3-acetyl-3-devinyl-pyropheophorbide-a bearing the C3-acetyl group with p-(un)substituted benzaldehydes under basic conditions. The corresponding porphyrin-type chlorophyll derivatives were prepared by the oxidation (17,18-didehydrogenation) of the chlorin-type. Their Qy absorption and fluorescence emission maxima in dichloromethane correlated well with Hammett substituent constants of the p-substituents. Several electron-withdrawing p-substituents suppressed the emission due to photoinduced electron transfer quenching in a molecule. The substitution sensitivities for their maxima and fluorescence quantum yields decreased in the order of bacteriochlorin-, chlorin-, and porphyrin-type derivatives.
关键词： Chlorophyll derivatives,Optical properties,Bacteriochlorin,Cross-aldol condensation,Hammett substituent constants,Porphyrin,Chlorin
更新于2025-09-23 15:21:01
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Highlya??Transparent and Truea??Colored Semitransparent Indoor Photovoltaic Cells
摘要： Organic photovoltaic (OPV) cells are promising indoor light energy harvesters because organic materials absorb strongly in the visible range. An indoor photovoltaic (IPV) device is an effective tool for the remote off-grid wireless charging. However, as the indoor light fluxes are much weaker than the 1-Sun condition, high-performance indoor cells should have large areas in order to generate appreciable energies. They would then appear as flat, but expansive and dark objects if deployed indoors. Their presence would then alter the indoor lighting environment and affect visual perceptions. This work addresses the lighting and perception issues of IPV cells in three ways. i) A concept is proposed such that a high-efficiency, semitransparent indoor OPV cell should possess an absorbance which is mismatched with the emission spectra of the light sources. ii) It is demonstrated that bulk heterojunction (BHJ) OPV solar cells with porphyrin donors can serve as high-transparency and high-efficiency indoor light harvesters. iii) Quantitative assessment criteria are presented for the transparency and chromaticity of an indoor semitransparent OPV cell, demonstrating that porphyrin-based P2:PC71BM semitransparent BHJ cells can achieve a power conversion efficiency (PCE) exceeding 10%, and an illuminance transparency ~65%, while preserving the color perception of the light sources.
关键词： porphyrin,indoor photovoltaics,human visual perception,semitransparent devices
更新于2025-09-23 15:21:01
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A Noble-Metal-Free Heterogeneous Photosensitizer-Relay-Catalyst Triad Catalyzes Water Oxidation under Visible Light
摘要： An entirely earth abundant chromophore-relay-water oxidation catalyst triad system, which is robust and efficient at neutral pH, is presented. The synthesis involves the coordination of a porphyrin derivative to a bridging Fe(CN)5 group, which is then reacted with Co ions to prepare a covalently linked chromophore-Prussian blue analogue assembly. Light driven water oxidation studies in the presence of an electron scavenger indicate that the triad is active and it maintains a steady activity for at least 3 hours. Transient absorption experiments and computational studies reveal that the Fe(CN)5 group is more than a linker as it takes part in electron-transfer and co-operates with porphyrin in the charge separation process.
关键词： water splitting,triad,dye-sensitized,water oxidation,Prussian blue,porphyrin
更新于2025-09-23 15:21:01
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Porphyrin-Stabilized Nitrenium Dication
摘要： Azepine-fused NiII-porphyrin dimer was synthesized by oxidative amination of b–b linked NiII-porphyrin dimer and its N-aryl congener was synthesized by two-fold Buchwald–Hartwig amination of b-to-b linked and dichlorinated NiII-porphyrin dimer. Oxidation of the NH congener gave neutral aminyl radical and nitrenium ion successively in a similar manner to the previously reported NH-bridged NiII-porphyrin dimer. On the other hand, oxidation of the N-aryl congener afforded formal nitrenium dication in a single-step two-electron oxidation. Stable nitrenium dications are rare that are isoelectronic to neutral trivalent boron compounds and tertiary carbocations. The chemical stability of the nitrenium dication has been improved by chlorine substitution at the most reactive b-position. The structural, optical, magnetic, electrochemical properties of these compounds mentioned above have been fully characterized.
关键词： dication,aminyl radical,nitrenium ion,azepine,porphyrin dimer
更新于2025-09-23 15:21:01
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Improvement of Power Conversion Efficiency of Quantum Dot-Sensitized Solar Cells by Doping of Manganese into a ZnS Passivation Layer and Cosensitization of Zinc-Porphyrin on a Modified Graphene Oxide/Nitrogen-Doped TiO <sub/>2</sub> Photoanode
摘要： It is vital to acquire power conversion efficiencies comparable to other emerging solar cell technologies by making quantum dot-sensitized solar cells (QDSSCs) competitive. In this study, the effect of graphene oxide (GO), nitrogen, manganese, and a porphyrin compound on the performance of QDSSCs based on a TiO2/CdS/ZnS photoanode was investigated. First, adding GO and nitrogen into TiO2 has a conspicuous impact on the cell efficacy. Both these materials reduce the recombination rate and expand the specific surface area of TiO2 as well as dye loading, reinforcing cell efficiency value. The maximum power conversion efficiency of QDSSC with a GO N-doped photoelectrode was 2.52%. Second, by employing Mn2+ (5 and 10 wt %) doping of ZnS, we have succeeded in considerably improving cell performance (from 2.52 to 3.47%). The reason for this could be for the improvement of the passivation layer of ZnS by Mn2+ ions, bringing about to a smaller recombination of photoinjected electrons with either oxidized dye molecules or electrolyte at the surface of titanium dioxide. However, doping of 15 wt % Mn2+ had an opposite effect and somewhat declined the cell performance. Finally, a Zn-porphyrin dye was added to the CdS/ZnS by a cosensitization method, widening the light absorption range to the NIR (near-infrared region) (>700 nm), leading to the higher short-circuit current density (JSC) and cell efficacy. Utilizing an environmentally safe porphyrin compound into the structure of QDSSC has dramatically enhanced the cell efficacy to 4.62%, which is 40% higher than that of the result obtained from the TiO2/CdS/ZnS photoelectrode without porphyrin coating.
关键词： graphene oxide,nitrogen doping,manganese doping,quantum dot-sensitized solar cells,cosensitization,Zn-porphyrin,power conversion efficiency
更新于2025-09-23 15:21:01
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Building from Ga-porphyrins: Synthesis of Ga-Acetylide complexes using acetylenes and polyynes
摘要： Multidimensional, conjugated building blocks have been formed through the axial coordination of polyynes to the central Ga atom of tetraarylporphyrins. Electron deficient pentafluorophenyl substituents in the meso-positions provide more stable s-acetylide complexes to Ga than analogous structures with tert-butylphenyl groups. Mono-, di-, and triynes have been used, including a pyridyl endcapped diyne that allows for formation of porphyrin triads through coordination of the pyridyl ligand to a Ru porphyrin.
关键词： hierarchical assembly,Ga-porphyrin,polyyne,supramolecular assembly,axial s-acetylide
更新于2025-09-23 15:21:01
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Novel approach to enhance light absorption of porphyrin/graphene oxide composites by PH and concentration modification for energy applications
摘要： Graphene oxide (GO) decorated with nanostructured porphyrin (PN) was synthesized and the interfacial interaction between these two components were investigated by using Scanning electron microscopy (SEM), X-ray, and UV-Visible absorption spectroscopy. These techniques showed good dispersion of GO and PN as well as a π-π intermolecular interaction confirming the energy/charge transfer. Moreover, X-ray diffraction study confirmed the intercalation of PN in GO and their disaggregation. The UV-Visible results showed an important interaction between GO and porphyrin nanorods under different pH values and concentrations resulting in the enhancement of optical absorption of GO-PN. The findings presented here are important to achieve the functionalization of graphene oxide with PN for various optoelectronic applications.
关键词： UV-Visible absorption,Porphyrin,Graphene,XRD,SEM
更新于2025-09-23 15:19:57