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The Vibration Behavior of Suba??Micrometer Gas Vesicles in Response to Acoustic Excitation Determined via Laser Doppler Vibrometry
摘要： The ability to monitor sub-micrometer gas vesicles’ (GVs) vibration behavior to nonlinear buckling and collapse using laser Doppler vibrometry is reported, providing a precise noncontact technique for monitoring the motion of sub-micrometer objects. The fundamental and first harmonic resonance frequencies of the vesicles are found to be 1.024 and 1.710 GHz, respectively. An interparticle resonance is furthermore identified at ≈300 MHz, inversely dependent upon the agglomerated GV size of around 615 nm. Most importantly, the vesicles amplify and broaden input acoustic signals at far lower frequencies—for example, 7 MHz—associated with medical and industrial applications, and they are found to transition from a linear to nonlinear response at 150 kPa and to collapse at 350 kPa or greater.
关键词： bubble dynamics,gas vesicles,sub-micrometer object metrology,acoustofluidics,laser Doppler vibrometry
更新于2025-09-19 17:13:59
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Fabrication of Silicon Microfluidic Chips for Acoustic Particle Focusing Using Direct Laser Writing
摘要： We have developed a fast and simple method for fabricating microfluidic channels in silicon using direct laser writing. The laser microfabrication process was optimised to generate microfluidic channels with vertical walls suitable for acoustic particle focusing by bulk acoustic waves. The width of the acoustic resonance channel was designed to be 380 μm, branching into a trifurcation with 127 μm wide side outlet channels. The optimised settings used to make the microfluidic channels were 50% laser radiation power, 10 kHz pulse frequency and 35 passes. With these settings, six chips could be ablated in 5 h. The microfluidic channels were sealed with a glass wafer using adhesive bonding, diced into individual chips, and a piezoelectric transducer was glued to each chip. With acoustic actuation at 2.03 MHz a half wavelength resonance mode was generated in the microfluidic channel, and polystyrene microparticles (10 μm diameter) were focused along the centre‐line of the channel. The presented fabrication process is especially interesting for research purposes as it opens up for rapid prototyping of silicon‐glass microfluidic chips for acoustofluidic applications.
关键词： acoustophoresis,acoustofluidics,ultrasound,laser micromachining,particle manipulation,microfabrication
更新于2025-09-16 10:30:52