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oe1(光电查) - 科学论文

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?? 中文（中国） ▾

  • Chemical and topographical single-cell imaging by near-field desorption mass spectrometry

    摘要： Simultaneous acquiring chemical and topographical information within a single cell at nanoscale resolutions is vital to cellular biology, yet it remains a great challenge for current techniques due to limited lateral resolutions and detection sensitivities. Here we report the development of near-field desorption mass spectrometry for co-registered chemical and topographical imaging, thereby bridging the gap between laser-based MS methods and multimodal single-cell imaging. Using this integrated platform, imaging resolution of 250 nm and 3D topographically reconstructed chemical single-cell imaging were achieved. This technique offers more in-depth cellular information than is currently possible with micrometre-range laser-based MS imaging methods. Considering the simplicity and compact size of the near-field device, this technique can be introduced to matrix-assisted laser desorption ionization MS, expanding the multimodal abilities of MS at nanoscale resolutions across wide disciplines.

    关键词： single-cell analysis,analytical methods,multimodal imaging,mass spectrometry,near-field desorption

    更新于2025-09-23 15:23:52

  • Smartphone-based analytical biosensors

    摘要： The traditional analytical biosensor instruments are relatively bulky, expensive, and not easy to handle, thus their applications are largely limited in resource-limited settings. The recent development of microfluidic lab-on-a-chip (LOC) technology has provided a possible solution to miniaturize the conventional biosensing system, yet other accessory devices to detect, readout, analyze, transfer, and display results are still required. With the rapid development, mass production, and pervasive distribution of smartphones in recent years, they have provided people with portable, cost-effective, and easy-to-operate platforms to build analytical biosensors for point-of-care (POC) applications and mobile health. Based on the common analytical methods, this paper reviews the recent development of four types of smartphone-based analytical biosensory systems at the POC, i.e., smartphone-based microscopic imaging, colorimetric, electrochemical, and electrochemiluminescence biosensor. The different bio-sensing strategies and analytical performance together with future perspectives are discussed.

    关键词： point-of-care,smartphone-based biosensors,analytical methods,mobile health,microfluidic

    更新于2025-09-19 17:15:36

  • Separation and Pre–Concentration of Metal Cations – DNA/RNA Chelates Using Molecular Beam Mass Spectrometry with Tunable Vacuum Ultraviolet (VUV) Synchrotron Radiation and Various Analytical Methods

    摘要： Separation and pre–concentration procedures such as Liquid–Liquid Extraction (LLE), Solid Phase Extraction (SPE) and Homogenous Liquid–Liquid Extraction (HLLE) make it feasible to determine the trace of metal cations such as Mg2+, Ca2+, Cr3+, Mn2+, Fe3+, Co2+, Co3+, Ni2+, Cu2+, Zn2+, Se2+, Mo6+, Ru4+, Rh3+, Pd2+, Ag+, Cd2+, Sn2+, Te2+, Te4+, Hg2+ and Pb2+ in natural samples using molecular beam mass spectrometry with tunable Vacuum Ultraviolet (VUV) synchrotron radiation (Figure 1) and various analytical methods [1-21]. Pre–concentration methods generally improve sensitivity and selectivity of the analysis with the additional advantage of isolation the analyte from the interfering compounds [22,23]. In the recent years, Homogenous Liquid– Liquid Extraction (HLLE) using molecular beam mass spectrometry with tunable Vacuum Ultraviolet (VUV) synchrotron radiation and various analytical methods has been extensively used in sample preparation due to speed, suitable performance, higher concentration factor and less solvent consumption in comparison with Liquid–Liquid Extraction (LLE) and Solid Phase Extraction (SPE) [24-44]. In the present editorial, an effective method is presented for pre–concentration of Mg2+, Ca2+, Cr3+, Mn2+, Fe3+, Co2+, Co3+, Ni2+, Cu2+, Zn2+, Se2+, Mo6+, Ru4+, Rh3+, Pd2+, Ag+, Cd2+, Sn2+, Te2+, Te4+, Hg2+ and Pb2+ by Homogenous Liquid–Liquid Extraction (HLLE) and using molecular beam mass spectrometry with tunable Vacuum Ultraviolet (VUV) Synchrotron radiation and various analytical methods.

    关键词： Separation,Pre–Concentration,Vacuum Ultraviolet (VUV) Synchrotron Radiation,Molecular Beam Mass Spectrometry,DNA/RNA Chelates,Metal Cations,Analytical Methods

    更新于2025-09-04 15:30:14