Cadmium Sulfide Quantum-Dot-Photocatalyzed Cascade Cyclization of Functionalized Difluoromethyl Chlorides with Unactivated Olefins

摘要： A cadmium sulfide quantum-dot-photocatalyzed C(sp3)?Cl bond cleavage of ethyl chlorodifluoroacetate and cascade cyclization with unactivated olefins is described herein. This reaction provides a cost-efficient method for synthesizing a wide range of CF2-containing azaheterocycles from functionalized difluoromethyl chlorides. Furthermore, the results of a preliminary anti-proliferative activity study indicate an in vitro anti-proliferative activity superior to that of doxorubicin with IC50 values of 1.140 μM on triple negative breast cancer (MDA-MB-231) and 2.129 μM on lung (A549) carcinoma cells.