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NIRS cerebral patterns in healthy late preterm and term infants are gender- and gestational age-dependent
摘要： Near infrared spectroscopy (NIRS) has been proposed to provide reliable information concerning brain oximetry and tissue activation level in the perinatal period. We aimed to investigate whether NIRS brain patterns in healthy preterm and term infants were gender- and gestational age-dependent. Methods: We conducted an observational study in 74 newborns, from consecutive singleton pregnancies, of whom 37 were born at term (male: n=19 female: n=18) and 37 (male: n=18 female: n=19) were preterm. Cerebral oximetry (crSO2) and fractional tissue oxygen extraction (cFTOE), were recorded on the 5th day from birth. Results: crSO2 was significantly higher and cFTOE lower (P<0.001, for both) in the preterm female than male group. At term crSO2 was significantly higher and cFTOE lower (P<0.001, for both) in males. crSO2 (male: R=0.84, P<0.001; female: R=0.74, P= P<0.001) and cFTOE (male: R=0.72, P<0.001; female: R=0.72, P<0.001) in male and female groups correlated positively with gestational age at recording. Conclusion: Different brain oximetry between males and females in preterm and term gestational ages, may suggest that in the perinatal period brain development is gender- and time-dependent. Data support the use of NIRS as a feasible tool for non-invasive cerebral monitoring.
关键词： newborn,NIRS,gender,brain development
更新于2025-09-10 09:29:36
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Imaging of endogenous hydrogen peroxide during the process of cell mitosis and mouse brain development with a near-infrared ratiometric fluorescent probe
摘要： Hydrogen peroxide (H2O2) is emerging as a new second messenger, which plays vital roles in intracellular signaling, thereby triggering physiological variations in terms of proliferation, differentiation, and migration. As known, cell mitosis has closely association to the intracellular level of H2O2, which contribute to the significant effects on the brain development, especially during the critical period of immaturity. Unfortunately, imaging H2O2 in mammalian brain is still challenging. Herein, to further investigate the biological roles of endogenous H2O2 in cells mitosis, we develop a near-infrared ratiometric fluorescent probe Cy-PFS for specifically imaging of endogenous H2O2 in cells and in vivo. Employing the probe Cy-PFS, we examine the critical effects of endogenous H2O2 on cells proliferation in live hippocampal neurons cells, our results provide strong evidences for H2O2 signaling in cell mitosis through growth factor signaling. Furthermore, we successfully demonstrate the close association of endogenous H2O2 level changes with the brain development at various stages. We envision that this present probe has potential as a promising useful chemical imaging tool for exploring the roles of H2O2 in cell mitosis.
关键词： cell mitosis,Hydrogen peroxide,endogenous H2O2,brain development,near-infrared ratiometric fluorescent probe
更新于2025-09-09 09:28:46