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oe1(光电查) - 科学论文

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出版时间
  • 2018
研究主题
  • electromagnetic pulse
  • cell proliferation
  • cell membrane permeability
  • cell response to electromagnetic stress
  • apoptosis
  • cancer therapy
  • necrosis
应用领域
  • Intelligent Medical Engineering
机构单位
  • V.N. Karazin Kharkiv National University
471 条数据
?? 中文（中国） ▾

  • Polydopamine-functionalized black phosphorus quantum dots for cancer theranostics

    摘要： Black phosphorus (BP) is a promising theranostic agent owing to its excellent photothermal property, biocompatibility and biodegradability. However, the rapid degradation of BP with oxygen and moisture causes the innate instability that is the Achilles’ heel of BP, hindering its further applications in cancer theranostics. Herein, a facile surface passivation strategy was developed to prepare polydopamine (PDA) coated BP quantum dots (QDs) (denoted as BP@PDA) through self-polymerization method. PDA with enriched phenol groups plays as a scavenger of reactive oxygen, which can efficiently prevent the oxidation of BP quantum dots and make them much stable in water (～90% for BP@PDA vs. only 10% for pure BP QDs after 10 days storage). Furthermore, PDA with strong near-infrared (NIR) absorption could greatly improve the photothermal conversion efficiency (PCE) of BP QDs from 22.6% to 64.2% (～2.84-fold higher). Considering the excellent biodegradability and good biocompability of both BP QDs and PDA, the as-prepared BP@PDA hold great potential for cancer theranostics.

    关键词： Photoacoustic imaging,Black phosphorus,Photothermal therapy,Cancer theranostics,Polydopamine

    更新于2025-11-19 16:56:42

  • One-step Aqueous Synthesis of Zn-based Quantum Dots as Potential Generators of Reactive Oxygen Species

    摘要： The actual incorporation of dopant species into the ZnS Quantum Dots (QDs) host lattice will induce structural defects evidenced by a red shift in the corresponding exciton. The doping should create new intermediate energetic levels between the valence and conduction bands of the ZnS and affect the electron-hole recombination. These trap states would favour the energy transfer processes involved with the generation of cytotoxic radicals, so-called Reactive Oxygen Species, opening the possibility to apply these nanomaterials in cancer research. Any synthesis approach should consider the direct formation of the QDs in biocompatible medium. Accordingly, the present work addresses the microwave-assisted aqueous synthesis of pure and doped ZnS QDs. As-synthesized quantum dots were fully characterized on a structural, morphological and optical viewpoint. UV-Vis analyzes evidenced the excitonic peaks at approximately 310 nm, 314 nm and 315 nm for ZnS, Cu-ZnS and Mn-ZnS, respectively, Cu/Zn and Mn/Zn molar ratio was 0.05%. This indicates the actual incorporation of the dopant species into the host lattice. In addition, the Photoluminescence spectrum of non-doped ZnS nanoparticles showed a high emission peak that was red shifted when Mn2+ or Cu2+ were added during the synthesis process. The main emission peak of non-doped ZnS, Cu-doped ZnS and Mn-doped ZnS were observed at 438 nm, 487 nm and 521 nm, respectively. Forthcoming work will address the capacity of pure and Cu-, Mn-ZnS quantum dots to generate cytotoxic Reactive Oxygen Species for cancer treatment applications.

    关键词： Cancer research,ZnS Quantum Dots,Doping,Microwave-assisted synthesis,Reactive Oxygen Species

    更新于2025-11-19 16:46:39

  • Green Synthesis of Carrier-Free Curcumin Nanodrugs for Light-activated Breast Cancer Photodynamic Therapy

    摘要： Photodynamic therapy (PDT) is a promising procedure for breast cancer therapy. Curcumin (Cur), a hydrophobic polyphenol derived from the spice turmeric, has been considered as a potential photosensitizer for PDT with evoked immune response, excellent safety, and low cost. However, the translation of curcumin in clinical cancer therapy suffers from an insufficient therapeutic dose in tumor tissues due to its poor solubility and low bioavailability. In this study, carrier-free curcumin nanodrugs (Cur NDs) were prepared without using any toxic solvents through a facile and green reprecipitation method. Cur NDs exhibited distinct optical properties, light-sensitive drug release behavior, resulting in increased reactive oxygen species (ROS) generation and PDT efficacy on breast cancer cells compared with free Cur. Furthermore, cell apoptosis during Cur-based PDT was concomitant with the activation of the ROS-mediated JNK/caspase-3 signaling pathway. Overall, our carrier-free Cur nanodrugs may be promising candidates for facilitating the efficacy and safety of PDT against breast cancer.

    关键词： Carrier-free,Curcumin,Light-responsive drug release,Breast cancer,Photodynamic therapy

    更新于2025-11-14 15:26:12

  • Changes in urine autofluorescence in ovarian cancer patients

    摘要： Ovarian cancer is the type of cancer with the highest mortality rate among gynaecologic malignancies. Due to lack of screening tools, this disease is mainly diagnosed at a progressed stage, when it is too late to adequate therapy. Despite many attempts, enough sensitive and specific biomarker was not still uncovered. Fluorescence spectroscopy has proven to be a useful diagnostic tool with high efficiency. Fluorescence detection has three major advantages over other light-based investigation methods: high sensitivity, high speed, and reliability. Biological materials consist of a number of intrinsic fluorescent compounds – autofluorophores, which are associated with cardinal metabolic pathways. It is well known, that cancerous tissue metabolism is altered compared to healthy one, what influence also intrinsic fluorophores composition of bodily fluids. Urine is one of the biological fluids that could be obtained most easily and displays a blue – green fluorescence that can change in case of pathological process. Analysis of urine autofluorescence is non invasive and simple technique. Using fluorescent spectroscopy, ovarian cancer patients and healthy control group were discerned with high significance, so we predict that fluorescence analysis of urine could be a potential means of ovarian cancer screening.

    关键词： fluorescence,cancer screening,urine,ovarian cancer

    更新于2025-09-23 15:23:52

  • Plasmonic Gold Nanovesicles for Biomedical Applications

    摘要： Gold nanoparticles (GNPs), with tunable optical properties, bioinertness, and surface multivalent effect, have been widely explored for biomedical applications. As one classical type of GNPs-based assemblies, plasmonic gold nanovesicles (GVs), with a hollow cavity, “solid skeleton” composed of GNPs cores and a “soft body” composed of functional polymers, have attracted considerable attention due to their tunable localized surface plasmon resonance, strong surface-enhanced Raman scattering properties, and high photothermal conversion efficiency. This review summarizes recent advances in biomedical applications for plasmonic GVs. Firstly, the synthesis methods of GVs are mainly including self-assembly and in situ gold growth methods. Secondly, the classification of GVs is described according to the morphology of GNPs cores. Thirdly, different biomedical applications of GVs are elaborated, including in vitro diagnosis, in vivo imaging, and in vivo therapy. Finally, the challenges and perspectives of GVs are discussed.

    关键词： cancer therapy,drug delivery,gold nanovesicles,biodetection,cancer imaging

    更新于2025-09-23 15:23:52

  • Photodynamic Therapy in the Treatment of Bladder Cancer: Past Challenges and Current Innovations

    摘要： There are limited treatment options for patients with recurrent non-muscle-invasive bladder cancer. In this report, we will talk about the history of photodynamic therapy; although it showed encouraging therapeutic results, it was largely abandoned due to toxicity or bystander effects on normal cells. Monoclonal antibody-conjugates represent an emerging therapeutic approach for malignancies that improves upon tumor specificity. The use of a monoclonal antibody-photosensitizer conjugate is a more selective method of delivering light therapy and has been termed 'photoimmunotherapy', which we will discuss in the last part of this report.

    关键词： Hematoporphyrin,Urothelial cancer,Hexaminolevulinic acid,Photoimmunotherapy,PIT,BCG-refractory NMIBC,PDT,Bladder cancer,5-Aminolevulinic acid,Photodynamic therapy

    更新于2025-09-23 15:23:52

  • Predicting interval and screen-detected breast cancers from mammographic density defined by different brightness thresholds

    摘要： Background: Case–control studies show that mammographic density is a better risk factor when defined at higher than conventional pixel-brightness thresholds. We asked if this applied to interval and/or screen-detected cancers. Method: We conducted a nested case–control study within the prospective Melbourne Collaborative Cohort Study including 168 women with interval and 422 with screen-detected breast cancers, and 498 and 1197 matched controls, respectively. We measured absolute and percent mammographic density using the Cumulus software at the conventional threshold (Cumulus) and two increasingly higher thresholds (Altocumulus and Cirrocumulus, respectively). Measures were transformed and adjusted for age and body mass index (BMI). Using conditional logistic regression and adjusting for BMI by age at mammogram, we estimated risk discrimination by the odds ratio per adjusted standard deviation (OPERA), calculated the area under the receiver operating characteristic curve (AUC) and compared nested models using the likelihood ratio criterion and models with the same number of parameters using the difference in Bayesian information criterion (ΔBIC). Results: For interval cancer, there was very strong evidence that the association was best predicted by Cumulus as a percentage (OPERA = 2.33 (95% confidence interval (CI) 1.85–2.92); all ΔBIC > 14), and the association with BMI was independent of age at mammogram. After adjusting for percent Cumulus, no other measure was associated with risk (all P > 0.1). For screen-detected cancer, however, the associations were strongest for the absolute and percent Cirrocumulus measures (all ΔBIC > 6), and after adjusting for Cirrocumulus, no other measure was associated with risk (all P > 0.07). Conclusion: The amount of brighter areas is the best mammogram-based measure of screen-detected breast cancer risk, while the percentage of the breast covered by white or bright areas is the best mammogram-based measure of interval breast cancer risk, irrespective of BMI. Therefore, there are different features of mammographic images that give clinically important information about different outcomes.

    关键词： Masking effect,Interval cancer,Screen-detected,Mammographic density,Australian women,Nested case–control cohort study,Mammography,Breast cancer

    更新于2025-09-23 15:23:52

  • Measurement of peripheral dose to pelvic region and associated risk for cancer development after breast intraoperative electron radiation therapy

    摘要： This study aimed to measure received dose to the pelvic region of patients during breast intraoperative electron radiation therapy (IOERT). Furthermore, we compared the findings with those of external beam radiation therapy. Finally, secondary ovary and uterus cancer risks following breast IOERT were estimated. In the current study, the received dose to the pelvic surface of 18 female patients during breast IOERT boost were measured by thermoluminescent dosimeter (TLD-100) chips. All patients were treated with 12 Gy given in a single fraction. To estimate the dose to the ovary and uterus of the patients, conversion coefficients for depth from surface dose were obtained in a Rando phantom. Given the received dose to the pelvic region of the patients, secondary ovary and uterus cancer risks following breast IOERT were estimated. The received doses to ovary and uterus surface of the patients were 0.260±0.155 mGy to 31.460±6.020 mGy and 0.485±0.122 mGy to 22.387±15.476 mGy, respectively. Corresponding intra-pelvic (ovary and uterus) regional doses were 0.012±0.007 mGy to 1.479±0.283 mGy and 0.027±0.001 mGy to 1.164±0.805 mGy, respectively. Findings demonstrated that the ratio of the received dose by pelvic surface to regional dose during breast IOERT was much less than external beam energies were 135.722±117.331 × 10-6 and 69.958±28.072 × 10-6, and for uterus were 17.342±10.583 × 10-6 and 2.971±3.604 × 10-6, respectively. According to our finding, the use of breast IOERT in pregnant patients can be considered as a safe radiotherapeutic technique, because the received dose to the fetus was lower than 50 mGy. Furthermore, IOERT can efficiently reduce the unnecessary dose to the pelvis region and lowers the risk of a secondary ovary and uterus cancer following breast irradiation.

    关键词： Breast cancer,peripheral dose,Radiation therapy,IOERT,Secondary cancer risk,pelvic region

    更新于2025-09-23 15:23:52

  • Efficacy of Hexaminolevulinate Photodynamic Diagnosis of Non-Muscle Invasive Bladder Cancer

    摘要： Objective: This study evaluated the efficacy of hexaminolevulinate fluorescence cystoscopy as a diagnostic tool for bladder cancer. The study was a case series in the Department of Urology in Hippokratio General Hospital of Athens between October 2008 and May 2012. Methods: Fifty patients (43 males and 7 females) who were investigated for hematuria were included in the study. White light cystoscopy (WLC) was first performed in all patients and after was performed a fluorescence cystoscopy (BLC-blue light cystoscopy). Biopsies were collected from any suspicious area and resection of the tumors identified (TUR).Whenever no suspicious areas could be seen, a standard random mapping including 8 biopsies overall was completed. Results: Patients demographic data and clinical history are presented in Table 1. Two-hundred twenty specimens were extracted and bladder cancer was diagnosed in 137. There were 17 CIS lesions all diagnosed with BLC whereas only 11 with WLC. WLC correctly diagnosed 109/140 specimens and the positive and negative predictive values were 77.9% and 65% respectively. The sensitivity and specificity were 79.6% and 62.6% respectively. BLC diagnosed 125/169 specimens and the positive and negative predictive values were 73.9% and 76.5% respectively. The sensitivity of BLC was 91.2% and the specificity 46.9%. Conclusion: Hexaminolevulinate-guided cystoscopy is a valuable diagnostic method, with considerably improved accuracy and improvement in diagnosis of non-muscle-invasive bladder cancer and especially CIS.

    关键词： Transurethral resection,Hexaminolevulinate-Guided cystoscopy,Bladder cancer

    更新于2025-09-23 15:23:52

  • NIR light-triggered gelling <i>in situ</i> of porous silicon nanoparticles/PEGDA hybrid hydrogels for localized combinatorial therapy of cancer cells

    摘要： Porous silicon-based nanocomposite hydrogels were readily constructed with the gelation of poly(ethylene glycol) double acrylates (PEGDA) macromers, due to the initiation of singlet oxygen photosensitized with porous silicon nanoparticles (PSiNPs) under near-infrared (NIR) light irradiation. Multifunctional PSiNPs/PEGDA nanocomposite hydrogels showed strong ?uorescence, excellent biodegradability, signi?cant photothermal effect, and sustained drug release with high ef?ciency (>80%). Finally, in situ growth of PSiNPs/PEGDA hybrid hydrogels on cancer cells was also achieved by NIR light, and then their biodegradation, drug release and synergistic chemo-phototherapeutic ef?cacy were further demonstrated, which could provide a signi?cant localized inhibition for the viability, adherence, and migration of cancer cells in vitro. Thus, we suggested that these resultant hybrid hydrogels would have important potential on local cancer therapy in future clinical practice.

    关键词： porous silicon nanoparticles,hybrid hydrogels,therapy,insitu gelation,localized cancer

    更新于2025-09-23 15:23:52