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Differential photothermal and photodynamic performance behaviors of gold nanorods, nanoshells and nanocages under identical energy conditions
摘要： Various gold (Au) nanostructures have shown promising near infrared (NIR) light-activated phototherapeutic effects; however, their reported photothermal or photodynamic performance behavior is usually inconsistent or even conflicted, dramatically limiting the improvement of phototherapeutic Au nanostructures. The potential reason for this uncertainty is mainly because the photoactivities of Au nanostructures are not evaluated under identical energy conditions. Herein, three Au nanostructures, Au nanorods (NRs), nanoshells (NSs), and nanocages (NCs), were prepared to provide the same localized surface plasmon resonance (LSPR) peaks at 808 nm. All these Au nanostructures (at the same optical density) could fully exert their photoactivities under the identical and optimal energy condition of 808 nm laser irradiation. It was found that these Au nanostructures could induce similar levels of temperature elevation but different levels of reactive oxygen species (ROS) production, where Au NCs exhibited the highest ROS production, followed by Au NSs and NRs. In vitro and in vivo phototherapeutic assessments further supported that Au NCs could cause the most severe cell death and tumor growth regression. This means that the identical incident energy has different contribution to photothermal and photodynamic performance of Au nanostructures, and the corner angle structures of Au NCs compared with NSs and NCs could more efficiently convert the photon energy into photodynamic property. Taken all together, Au NCs hold great potential for phototherapy due to their efficient energy utilization capability.
关键词： reactive oxygen species,photodynamic therapy,gold nanostructures,photothermal therapy,cancer treatment
更新于2025-11-21 11:08:12
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Improvement of Cancer Therapy by TAT Peptide Conjugated Gold Nanoparticles
摘要： Gold nanoparticles (AuNPs) are potent anticancer agent that controls drug delivery to tumors. Here, we describe the identification of TAT-Cell Penetrating Peptide (TAT-CPP) conjugated AuNPs, as a novel delivery system to the cancerous regions. TAT-peptide was modified to BSA-AuNPs [Bovine Serum Albumin (BSA) coated AuNPs] electrostatically. The binding efficiency of TAT-AuNPs was tested using Dynamic Light Scattering, UV–Vis spectrophotometer and Zeta potential. The nano-complex (BSA-AuNPs; with and without TAT-CPP) was applied against Rhabdomyosarcoma and Murine fibroblast (L20B) cancer lines, in vitro. Cytotoxicity effect was evaluated by MTT assay at 0.125, 0.25, 0.5 and 1 mg/ml concentration for 24 and 48 h incubation time. Results demonstrated that TAT-(BSA-AuNPs) exhibits significant toxicity for both cancer cell lines. TAT-CPP has improved cancer cell reduction, where cytotoxicity more than 80% has been achieved. This study was conducted to achieve the simplicity and facility in cancer therapy, where the small-sized TAT-AuNPs acts as a simple therapeutic agent in the specific delivery and targeting the deep, irregular, and complicated cancer regions in the human body. Therefore, it could replace other cancer treatment techniques, even dispense the laser irradiation in the phototherml therapy.
关键词： BSA,CPP,Small sized gold nanoparticles,Cancer treatment,TAT
更新于2025-09-23 15:23:52
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Nonrigid reconstruction of 3D breast surfaces with a low-cost RGBD camera for surgical planning and aesthetic evaluation
摘要： Accounting for 26% of all new cancer cases worldwide, breast cancer remains the most common form of cancer in women. Although early breast cancer has a favourable long-term prognosis, roughly a third of patients suffer from a suboptimal aesthetic outcome despite breast conserving cancer treatment. Clinical-quality 3D modelling of the breast surface therefore assumes an increasingly important role in advancing treatment planning, prediction and evaluation of breast cosmesis. Yet, existing 3D torso scanners are expensive and either infrastructure-heavy or subject to motion artefacts. In this paper we employ a single consumer-grade RGBD camera with an ICP-based registration approach to jointly align all points from a sequence of depth images non-rigidly. Subtle body deformation due to postural sway and respiration is successfully mitigated leading to a higher geometric accuracy through regularised locally affine transformations. We present results from 6 clinical cases where our method compares well with the gold standard and outperforms a previous approach. We show that our method produces better reconstructions qualitatively by visual assessment and quantitatively by consistently obtaining lower landmark error scores and yielding more accurate breast volume estimates.
关键词： Breast cancer treatment,Nonrigid registration,Depth camera,3D surface reconstruction,Aesthetic evaluation
更新于2025-09-23 15:23:52
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Photoimmunoconjugates: novel synthetic strategies to target and treat cancer by photodynamic therapy
摘要： Photodynamic therapy (PDT) combines a photosensitizer (PS) with the physical energy of non-ionizing light to trigger cell death pathways. PDT has potential as a therapeutic modality to be used in alternative or in combination with other conventional cancer treatment protocols (e.g. surgery, chemotherapy and radiotherapy). Still, due to the lack of specificity of the current PSs to target the tumor cells, several studies have exploited their conjugation with targeting moieties. PSs conjugated with antibodies (Abs) or their fragments, able to bind antigens overexpressed in the tumors, have demonstrated potential in PDT of tumors. This review provides an overview of the most recent advances on photoimmunoconjugates (PICs) for cancer PDT, which involve the first and second-generation PSs conjugated to Abs. This is an update of our previous review “Antibodies armed with photosensitizers: from chemical synthesis to photobiological applications”, published in 2015 in Org. Biomol. Chem.
关键词： Photoimmunoconjugates,Antibody conjugation,Photosensitizers,Cancer treatment,Photodynamic therapy
更新于2025-09-23 15:22:29
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A high therapeutic efficacy of polymeric prodrug nano-assembly for a combination of photodynamic therapy and chemotherapy
摘要： Combination of photodynamic therapy and chemotherapy has been emerging as a new strategy for cancer treatment. Conventional photosensitizer tends to aggregate in aqueous media, which causes fluorescence quenching, reduces reactive oxygen species (ROS) production, and limits its clinical application to photodynamic therapy. Traditional nanoparticle drug delivery system for chemotherapy also has its disadvantages, such as low drug loading content, drug leakage, and off-target toxicity for normal tissues. Here, we developed a reduction-sensitive co-delivery micelles TB@PMP for combinational therapy, which composed of entrapping a red aggregation-induced emission fluorogen (AIEgen) for photodynamic therapy and PMP that contains a reduction-sensitive paclitaxel polymeric prodrug for chemotherapy. AIEgen photosensitizer illustrates a much improved photostability and ROS production efficiency in aggregate state and PMP loads a high dose of paclitaxel and carries a smart stimuli-triggered drug release property. This co-delivery system provides a better option that replaces AIEgen photosensitizer for cancer diagnosis and therapy.
关键词： chemotherapy,polymeric prodrug,cancer treatment,photodynamic therapy,nanoparticles
更新于2025-09-23 15:21:21
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Applications of Nanotechnology in Cancer: A Literature Review of Imaging and Treatment
摘要： Recent advances in the application of nanotechnology in medicine, often referred to as nanomedicine, may revolutionize our approach to healthcare. Cancer nanotechnology is a relatively novel interdisciplinary area of comprehensive research that combines the basic sciences, like biology and chemistry, with engineering and medicine. Nanotechnology involves creating and utilizing the constructs of variable chemistry and architecture with dimensions at the nanoscale level comparable to those of biomolecules or biological vesicles in the human body. Operating with submolecular interactions, it offers the potential for unique and novel approaches with a broad spectrum of applications in cancer treatment including areas such as diagnostics, therapeutics, and prognostics. Nanotechnology also opens pathways to developing new and efficient therapeutic approaches to cancer treatment that can overcome numerous barriers posed by the human body compared to conventional approaches. Improvement in chemotherapeutic delivery through enhanced solubility and prolonged retention time has been the focus of research in nanomedicine. The submicroscopic size and flexibility of nanoparticles offer the promise of selective tumor access. Formulated from a variety of substances, nanoparticles are configured to transport myriad substances in a controlled and targeted fashion to malignant cells while minimizing the damage to normal cells. They are designed and developed to take advantage of the morphology and characteristics of a malignant tumor, such as leaky tumor vasculature, specific cell surface antigen expression, and rapid proliferation. Nanotechnology offers a revolutionary role in both diagnostics (imaging, immune-detection) and treatment (radiation therapy, chemotherapy, immunotherapy, thermotherapy, photodynamic therapy, and anti-angiogenesis). Moreover, nanoparticles may be designed to offer a multifunctional approach operating simultaneously as an effective and efficient anticancer drug as well as an imaging material to evaluate the efficacy of the drug for treatment follow-up. In recent years, nanomedicine has exhibited strong promise and progress in radically changing the approach to cancer detection and treatment.
关键词： Cancer treatment,Nanotechnology,Imaging
更新于2025-09-23 15:21:21
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A Dual-Targeted Organic Photothermal Agent for Enhanced Photothermal Therapy
摘要： The development of highly effective anticancer drugs that cause minimal damage to the surrounding normal tissues represents a challenging topic in cancer therapy. Herein, we demonstrate a dual-targeted organic molecule that functions as a photothermal agent via active targeting of tumor tissues and mitochondria for selectively killing cancer cells. The synthesized photothermal agent exhibits high photothermal conversion efficiency, low cytotoxicity and good biological compatibility in photothermal therapy. In vivo experiments show that an excellent tumor inhibitory effect can be achieved with the dual-targeted photothermal agent.
关键词： Cancer treatment,Dual-targeting delivery,Therapeutic agents,Photothermal therapy,Organic photothermal agents
更新于2025-09-23 15:21:01
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Nanostructures for Cancer Therapy || Dose enhancement effect in radiotherapy: adding gold nanoparticles to tumor in cancer treatment
摘要： The rationale of radiation dose enhancement due to gold nanoparticle addition in radiotherapy is revealed from the basic particle interactions to Monte Carlo simulation. Our review of different radiobiological studies on Monte Carlo, cell line, and preclinical model confirms that cancer cell kill definitely benefits from the dose enhancement when gold nanoparticles were added. Moreover, such dose enhancement depends on the size, shape, and concentration of the gold nanoparticle, as well as the type and energy of the radiation beams. It is concluded that adding gold nanoparticles to the tumor can enhance both the dose and contrast at the target in radiotherapy.
关键词： radiotherapy,cancer treatment,Monte Carlo simulation,gold nanoparticles,dose enhancement
更新于2025-09-23 15:21:01
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A Dual-Targeted Organic Photothermal Agent for Enhanced Photothermal Therapy
摘要： The development of highly effective anticancer drugs that cause minimal damage to the surrounding normal tissues represents a challenging topic in cancer therapy. Herein, we demonstrate a dual-targeted organic molecule that functions as a photothermal agent via active targeting of tumor tissues and mitochondria for selectively killing cancer cells. The synthesized photothermal agent exhibits high photothermal conversion efficiency, low cytotoxicity and good biological compatibility in photothermal therapy. In vivo experiments show that an excellent tumor inhibitory effect can be achieved with the dual-targeted photothermal agent.
关键词： Cancer treatment,Dual-targeting delivery,Therapeutic agents,Photothermal therapy,Organic photothermal agents
更新于2025-09-23 15:21:01
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Dataset concerning plasmonic thermal destruction of murine melanoma by gold nanoparticles obtained by green chemistry
摘要： The data presented in this article are related to the research paper “Proof of concept of plasmonic thermal destruction of surface cancers by gold nanoparticles obtained by green chemistry” (Ben Hadadda et al, 2019). In this article, we examined plasmonic thermal destruction of murine melanoma using gold nanoparticles obtained by green chemistry. The presented data were obtained by measuring tumor volume and mice weight in different groups of mice murine melanoma B16F10 treated or not with the nanoparticles and coupled to laser irradiation. These data were compared to the clinical reference treatment: anti-PD1 monoclonal antibody. The data were analyzed in order to be able to compare the antitumor effect of our treatment (photothermal plasmonic therapy using gold nanoparticles) and the reference treatment.
关键词： Green chemistry,Photothermal therapy,Cancer treatment,Gold nanoparticles,Murine melanoma
更新于2025-09-23 15:19:57