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Sensing biomarkers with plasmonics
摘要： The detection of biomarkers is critical for enabling early disease diagnosis, monitoring the progression, and tracking the effectiveness of therapeutic intervention. Plasmonic sensors exhibit a broad range of analytical capabilities, from the rapid generation of colorimetric readouts to single-molecule sensitivity in ultralow sample volumes, which have led to their increased exploration in bioanalysis and point-of-care applications. This perspective presents selected accounts of recent developments on the different types of plasmonic sensing platforms, the pervasive challenges and outlook on the pathway to translation. We highlight the sensing of upcoming biomarkers including microRNA, circulating tumor cells, exosomes, and cell-free DNA, and discuss the opportunity of utilizing plasmonic nanomaterials and tools for biomarker detection beyond biofluids, such as in tissues, organs, and disease sites. The integration of plasmonic biosensors with established and upcoming technologies of instrumentation, sample pre-treatment, and data analysis will help realize their translation to clinical settings for improving healthcare and enhancing the quality of life.
关键词： plasmonics,exosomes,biomarkers,microRNA,biosensors,circulating tumor cells,cell-free DNA
更新于2025-09-23 15:21:01
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Extracellular biosynthesis of cadmium sulphide quantum dot using cell-free extract of Pseudomonas chlororaphis CHR05 and its antibacterial activity
摘要： For the ?rst time a novel aquatic bacterium belonging to strain of Pseudomonas chlororaphis was developed for the synthesis of cadmium sul?de quantum dots. The cadmium sulfate solution incubated with cell-free extract (CFE) of P. chlororaphis strain CHR05 to generate cadmium sul?de nanoparticles (CdSNps) which were characterized with combined spectroscopy and microscopy analyses. The preliminary con?rmation on the formation of CdSNps was done by UV–vis and ?uorescence analyses with the absorption and emission spectra at 435 and 475 nm, respectively. EDX pattern shows that the CdSNps are composed of the elementals Cd and S. Also, XRD analysis of the puri?ed nanoparticles con?rmed the formation of CdSNps. FE-SEM, TEM, and DLS analyzed the size and morphology of the CdSNps. The biosynthesis of CdSNps with the strategy of cell free extract was investigated under optimum conditions. After 24 h of incubation, the results showed that the novel isolated strain can produce spherical CdSNps with an average size of 6.7 ± 2.4 nm, after exposure to CdSO4 solution (2.5 mM) at pH 7.5 and 30 °C. The antibacterial activity CdSNps against some Gram-positive and -negative bacteria were determined using agar well di?usion method and microplate method which has growth-inhibitory e?ect all on tested bacteria.
关键词： CdSNps,Cell-free extract,P. chlororaphis strain CHR05,Antibacterial activity
更新于2025-09-12 10:27:22
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[IEEE 2018 Conference on Precision Electromagnetic Measurements (CPEM 2018) - Paris, France (2018.7.8-2018.7.13)] 2018 Conference on Precision Electromagnetic Measurements (CPEM 2018) - Rabi Resonance Measurements Based on CS Vapor Cell for Microwave Magnetic Field Detection in Free Space
摘要： In this paper we characterized the lineshapes of Rabi resonances for microwave (MW) magnetic field with cesium vapor cell in free space. The relation between resonance lineshapes and phase modulation frequency under different experimental parameters are investigated. Based on the obtained lineshapes, the evaluation of Rabi frequency has been done in free space. Optimal laser intensity and cell temperature are obtained in our experiment, preliminary analysis of the experimental results is reported.
关键词： Atom-based microwave measurements,lineshapes,atomic vapor cell,free space,magnetic field,Rabi resonance
更新于2025-09-10 09:29:36
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[IEEE 2018 IEEE 5G World Forum (5GWF) - Silicon Valley, CA (2018.7.9-2018.7.11)] 2018 IEEE 5G World Forum (5GWF) - Energy-Efficient Downlink Power Control in mmWave Cell-Free and User-Centric Massive MIMO
摘要： This paper considers cell-free and user-centric approaches for coverage improvement in wireless cellular systems operating at millimeter wave frequencies, and proposes downlink power control algorithms aimed at maximizing the global energy efficiency. To tackle the non-convexity of the problems, an interaction between sequential and alternating optimization is considered. The use of hybrid analog/digital beamformers is also taken into account. The numerical results show the benefits obtained from the power control algorithm, as well as that the user-centric approach generally outperforms the cell-free one.
关键词： downlink power control,massive MIMO,user-centric,energy efficiency,mmWave,cell-free
更新于2025-09-04 15:30:14