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Imaging-based target volume reduction in chemoradiotherapy for locally advanced non-small-cell lung cancer (PET-Plan): a multicentre, open-label, randomised, controlled trial
摘要： With increasingly precise radiotherapy and advanced medical imaging, the concept of radiotherapy target volume planning might be redefined with the aim of improving outcomes. We aimed to investigate whether target volume reduction is feasible and effective compared with conventional planning in the context of radical chemoradiotherapy for patients with locally advanced non-small-cell lung cancer.
关键词： chemoradiotherapy,Imaging-based target volume reduction,randomised,multicentre,controlled trial,open-label,PET-Plan,locally advanced non-small-cell lung cancer
更新于2025-09-23 15:19:57
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685PA MULTICENTER PHASE II STUDY OF SALVAGE PHOTODYNAMIC THERAPY USING TALAPORFIN SODIUM AND A DIODE LASER FOR LOCAL FAILURE OF ESOPHAGEAL CANCER AFTER CHEMORADIOTHERAPY
摘要： We previously reported that photodynamic therapy (PDT) has a potential to cure local failure after chemoradiotherapy (CRT) for esophageal cancer (EC). However, first-generation PDT using porfimer sodium and an excimer dye laser has several problems: a high occurrence of skin phototoxicity, the requirement of a long light shielding period (6 weeks), and the need for an expensive and large laser generator. Talaporfin sodium (Laserphyrin?) is a second-generation photosensitizer that requires a shorter light shielding period (2 weeks) and induces less phototoxicity. We previously identified the optimum diode laser fluence (100 J/cm2) for PDT using talaporfin sodium in the phase I/IIA study. Therefore, in the present study, we conducted a multicenter phase IIB study to evaluate the efficacy and safety of PDT using talaporfin sodium as a salvage treatment for local failure after CRT or radiotherapy (RT) for EC. (UMIN000009184).
关键词： chemoradiotherapy,non-colorectal,esophageal cancer,photodynamic therapy,talaporfin sodium,diode laser,gastrointestinal tumours
更新于2025-09-23 15:19:57
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External validation of a combined PET and MRI radiomics model for prediction of recurrence in cervical cancer patients treated with chemoradiotherapy
摘要： Purpose The aim of this study was to validate previously developed radiomics models relying on just two radiomics features from 18F-fluorodeoxyglucose positron emission tomography (PET) and magnetic resonance imaging (MRI) images for prediction of disease free survival (DFS) and locoregional control (LRC) in locally advanced cervical cancer (LACC). Methods Patients with LACC receiving chemoradiotherapy were enrolled in two French and one Canadian center. Pre-treatment imaging was performed for each patient. Multicentric harmonization of the two radiomics features was performed with the ComBat method. The models for DFS (using the feature from apparent diffusion coefficient (ADC) MRI) and LRC (adding one PET feature to the DFS model) were tuned using one of the French cohorts (n = 112) and applied to the other French (n = 50) and the Canadian (n = 28) external validation cohorts. Results The DFS model reached an accuracy of 90% (95% CI [79–98%]) (sensitivity 92–93%, specificity 87–89%) in both the French and the Canadian cohorts. The LRC model reached an accuracy of 98% (95% CI [90–99%]) (sensitivity 86%, specificity 100%) in the French cohort and 96% (95% CI [80–99%]) (sensitivity 83%, specificity 100%) in the Canadian cohort. Accuracy was significantly lower without ComBat harmonization (82–85% and 71–86% for DFS and LRC, respectively). The best prediction using standard clinical variables was 56–60% only. Conclusions The previously developed PET/MRI radiomics predictive models were successfully validated in two independent external cohorts. A proposed flowchart for improved management of patients based on these models should now be confirmed in future larger prospective studies.
关键词： External validation,Prediction,Cervical cancer,Chemoradiotherapy,Radiomics
更新于2025-09-04 15:30:14