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Multimodal imaging based biomarkers predictive of early and late response to anti-VEGFs during the first year of treatment for neovascular age-related macular degeneration
摘要： Purpose. — To evaluate baseline predictive markers of early and late anatomical response to anti-vascular endothelial growth factor (anti-VEGF) treatment in patients with neovascular age-related macular degeneration (nAMD). Methods. — The records of the nAMD patients who underwent intravitreal ranibizumab or aflibercept treatment, received the 3 monthly loading doses, and completed a follow-up period of 12 months were included retrospectively. The anatomical treatment response at month 3 (early) and between month 3 and 12 (late) was classified as good, intermediate or poor. Baseline demographic, fluorescein angiography, and optical coherence tomography findings were compared among the three groups. Results. — One hundred and ten eyes (74.3%) showed good, 18 (12.2%) showed intermediate and 20 (13.5%) showed poor anatomical response at month 3, and 114 eyes (77.0%) showed good, 27 (18.2%) showed intermediate and 7 (4.7%) showed poor anatomical response between month 3 and month 12. Of the evaluated parameters, drug type (better in aflibercept), showed a statistically significant difference in regards to anatomical outcomes at both the early and late periods (P = 0.02 and P = 0.03). The greatest linear dimension of choroidal neovascularization (CNV) and presence of peaked pigment epithelial detachment (PED) were important factors for early anatomical anti-VEGF treatment response. Conclusion. — Larger CNV and the presence of a peaked PED appeared to be associated with a good early response, and the drug type seemed to be associated with both early and late poor anatomical response of anti-VEGF treatment in nAMD patients. Aflibercept appears to be more effective than ranibizumab in regards to the percentage of patients with better anatomical response in both the early and late treatment periods.
关键词： Optical coherence tomography,Ranibizumab,Age-related macular degeneration,Aflibercept,Fluorescein angiography
更新于2025-09-23 15:22:29
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Evaluation of calculus imaging on root surfaces by spectral-domain optical coherence tomography
摘要： Objective: The aim of this in vitro study was to evaluate the ability of optical coherence tomography (OCT) to display calculus on root surfaces. Material and Methods: Ten teeth with calculus on the root surface were embedded in resin, omitting the root surface. A region of interest (ROI) was marked by small drill holes coronally and apically of the calculus and imaged by spectral-domain optical coherence tomography ([SD OCT], Telesto SP5, centre wavelength 1310 nm) and light microscopy (LM). To evaluate the impact of different fluids on calculus visualisation, using OCT, root surfaces were covered by a layer of NaCl and blood and displayed by OCT. Subsequently, teeth were completely covered with resin and sectioned for histological evaluation. Within the ROI, lengths of root surface and calculus were measured by LM and OCT, and the ratio [%] was calculated. In addition, at three sites of each ROI, agreement of presence and length of calculus was evaluated. Both methods were compared using Pearson’s correlation. Results: Regarding the presence of calculus, agreement between LM and OCT was strong (κi = 0.783, p = 0.033), and measurements regarding the length of the calculus were strongly correlated (ri >0.906; pi <0.001). However, the values differed for dry (p = 0.023) and NaCl-covered root surfaces (p = 0.035). Conclusion: Calculus on the root surface can be displayed by SD-OCT, which therefore may be suited as imaging technology for subgingival calculus in periodontal pockets.
关键词： Optical coherence tomography Periodontitis Subgingival calculus Diagnosis SD-OCT
更新于2025-09-23 15:22:29
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The role of optical coherence tomography in the evaluation of compressive optic neuropathies
摘要： Purpose of review Optical coherence tomography (OCT) is a noninvasive imaging tool routinely used in ophthalmology that provides cross-sectional images of the retina. Compression of the anterior visual pathways results in progressive thinning of the retinal nerve fiber layer (RNFL) and macular ganglion cell complex (GCC) and this review will highlight the utility of OCT in evaluating patients with this condition. Recent findings The RNFL and macular GCC have been found to highly correlate with visual function in patients with compressive optic neuropathies. Preoperative RNFL and macular GCC thickness have emerged as the most reliable and consistent prognostic factors for visual recovery after surgery. Patients with an otherwise normal neuroophthalmic examination, including automated perimetry, may have macular GCC or RNFL thinning as the only manifestation of compression, enabling compressive optic neuropathies to be diagnosed at an earlier stage and managed accordingly. Summary Recent findings indicate that OCT is an important tool in the evaluation of patients with compressive optic neuropathies, particularly for prognosis in patients with visual field defects and diagnosis in patients with preserved or mildly reduced visual function. Anatomical changes detected by OCT may precede visual loss and allow for earlier diagnosis and presumably better visual outcomes.
关键词： optic neuropathy,anterior visual pathways,pituitary adenoma,optical coherence tomography
更新于2025-09-23 15:22:29
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Optimal distillation of quantum coherence with reduced waste of resources
摘要： We present an optimal probabilistic protocol to distill quantum coherence. Inspired by a specific entanglement distillation protocol, our main result yields a strictly incoherent operation that produces one of a family of maximally coherent states of variable dimension from any pure quantum state. We also expand this protocol to the case where it is possible, for some initial states, to avert any waste of resources as far as the output states are concerned, by exploiting an additional transformation into a suitable intermediate state. These results provide practical schemes for efficient quantum resource manipulation.
关键词： distillation,resource theory,quantum coherence,strictly incoherent operations
更新于2025-09-23 15:22:29
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Integrating Handcrafted and Deep Features for Optical Coherence Tomography Based Retinal Disease Classification
摘要： Deep Neural Networks (DNNs) have been widely applied to automatic analysis of medical images for disease diagnosis, and to help human experts by efficiently processing immense amounts of images. While handcrafted feature has been used for eye disease detection or classification since the 1990s, DNN was recently adopted in this area and showed very promising performance. Since handcrafted and deep feature can extract complementary information, we propose in this paper three different integration frameworks to combine handcrafted and deep feature for optical coherence tomography (OCT) image based eye disease classification. In addition, to integrate the handcrafted feature at Input and Fully Connection (FC) layers using existing networks like VGG, DenseNet and Xception, a novel ribcage network (RC Net) is also proposed for feature integration at middle layers. For RC Net, two “rib” channels are designed to independently process deep and handcrafted features, and another so called “spine” channel is designed for the integration. While dense blocks are the main components of the three channels, sum operation is proposed for the feature map integration. Our experimental results showed that the deep networks achieved better classification accuracy after integration of the handcrafted features e.g. SIFT and Gabor. The RC Net showed the best performance among all proposed feature integration methods.
关键词： feature integration,deep learning,Artificial intelligence,optical coherence tomography
更新于2025-09-23 15:22:29
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[IEEE 2018 IEEE International Ultrasonics Symposium (IUS) - Kobe, Japan (2018.10.22-2018.10.25)] 2018 IEEE International Ultrasonics Symposium (IUS) - High Intensity Focused Ultrasound (HIFU) Combines Optical Coherence Tomography(OCT) for Biological Tissue Treatment and Evaluation
摘要： Light intensity focused ultrasound (LIFU) is an early stage medical technology that is in various stages of development to treat a range of disorders including super?cial diseases. Optical coherence tomography (OCT) is a rapid development imaging technique in recent ten years, which is a good way to monitor the tissue structure of super?cial diseases. In this study, OCT system is used to monitor the tissue structure of super?cial diseases during LIFU treatment. During the treatment, LIFU was performed on the lesion area of the sample with different energy levels for different times: 5s, 10s, 15s, 20s, 25s, 30s, respectively. During the treatment, the OCT system was working to monitor the tissue structure. The results showed that the light intensity of the lesion area increased with the treatment time, and the structure of the tissue changed. This study provides a new method for monitoring the treatment of super?cial diseases with LIFU.
关键词： Monitoring,Optical coherence tomography,Tissue structure,Super?cial diseases,Light intensity focused ultrasound
更新于2025-09-23 15:22:29
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Evaluation of art subjects implemented in the marquetry technique by the optical coherence microscopy method
摘要： Evaluation of internal microstructure of decorative and applied art objects implemented in the intarsia and marquetry techniques by the optical coherence tomography method is considered. The high resolving optical coherence microscope with a radiation source with tunable wavelength in the range of 1305 ± 75 nm was applied. The ability to analyse layered microstructure of wood object surface layer in intarsia regions is demonstrated. The geometric features evaluation of the object's microstructure in the areas of interest was conducted. Systematisation of layers structure and typical defects inherent in intarsia regions was performed considering the structural features that may be important for restoration of such objects. Examples of experimentally obtained B‐scans and three‐dimensional representations of sample fragments of microstructure studied by the optical coherence microscopy method are given.
关键词： intarsia,optical coherence microscopy,incrustation,marquetry,3‐D imaging
更新于2025-09-23 15:22:29
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A Comprehensive Model for Correcting RNFL Readings of Varying Signal Strengths in Cirrus Optical Coherence Tomography
摘要： PURPOSE. To develop a model for the Cirrus HD-OCT that allows for the comparison of retinal nerve fiber layer (RNFL) thickness measurements with dissimilar signal strengths (SS) and accounts for test–retest variability. METHODS. Retinal nerve fiber layers were obtained in normals using the Cirrus optic disc cube 200 3 200 protocol during a single encounter. Five RNFL scans were obtained with a SS of 9 or 10. Diffusion lens filters were used to degrade SS to obtain five scans at each SS group of 7 or 8, 5 or 6, and 3 or 4. The relationship between average RNFL thickness and SS was established, and an equation was developed to allow for adjustment of an RNFL measurement had it been a SS of 7. Intravisit interclass correlation coefficient (ICC) and coefficient of variation (CV) parameter estimates for each SS group were calculated. Repeatability and upper tolerance limit were calculated as 1.96 3 =2 3 within-subject standard deviation (Sw) and 1.645 3 =2 3 Sw, respectively. RESULTS. There was a linear relationship between average RNFL and SS. RNFLadj ? RNFL (cid:2) 1.03*SS t 7.21 allows for the adjustment of RNFL readings to the same SS. Interclass correlation coefficients and CVs were good for all measurements down to SS of 3 or 4. Repeatability and upper tolerance limit were 5.24 and 4.40 lm, respectively. CONCLUSIONS. Our model adjusts RNFL readings based on SS and includes an upper tolerance limit of 5 lm. If validated, this model could improve the detection of real RNFL changes. Further study to validate this model should be performed before widespread use is adopted.
关键词： glaucoma anterior segment,Cirrus OCT,signal strength,optical coherence tomography
更新于2025-09-23 15:22:29
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Cell Motility as Contrast Agent in Retinal Explant Imaging With Full-Field Optical Coherence Tomography
摘要： PURPOSE. To use cell motility as a contrast agent in retinal explants. METHODS. Macaque and mouse retinal explants were imaged with high resolution full field optical coherence tomography (FFOCT) and dynamic FFOCT, coupled with fluorescence imaging. RESULTS. Static and dynamic FFOCT create complementary contrast from different structures within a cell. When imaging in vitro samples, static FFOCT detects steep refractive index gradients to reveal stationary structures including fibers, vessels, collagen, and cell contours, while dynamic FFOCT emphasizes metabolic activity of moving structures that are mainly intracellular, thus creating or enhancing contrast in cells that were previously hidden in noise. Dynamic FFOCT enables detection of most of the retinal cell types in the ganglion cell, inner and outer nuclear layers, where static FFOCT contrast is too low in relation to the noise background. CONCLUSIONS. Composite static and dynamic FFOCT provides a new kind of FFOCT image containing valuable information for imaging of retinal explants. It provides label-free en face images of living retinas, with a subcellular resolution. Dynamic FFOCT adds information about cell activity, which is of interest in longitudinal explant studies.
关键词： explant,motility,optical coherence tomography
更新于2025-09-23 15:22:29
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[IEEE 2018 China International SAR Symposium (CISS) - Shanghai (2018.10.10-2018.10.12)] 2018 China International SAR Symposium (CISS) - A Phase Reconstruction Method for Ground-Based Interferometric SAR
摘要： Ground-based interferometric SAR (GB-InSAR) technology is becoming an important terrain mapping technology as it has the characteristics of short observation interval, flexible operation environment and high data precision. Compared with the other air borne/space borne InSAR system, the GB-InSAR system has different image resolution, observation geometry and observation range. Thus, based on those features above, the interferometric phase of GB-InSAR has its own particularity. Mainly shows in the small offset between master and slave image, different decoherence sources, and the low-coherence area caused by varying viewing angle. This paper propose an interferometric phase processing method in order to recognize and compensate the low-coherence area based on their multi-characteristics, and rebuild the interferometric phase by using signal-domain estimation technology. This method will provide the satisfactory interferometric phase image for the following terrain map generation.
关键词： signal-domain phase reconstruction,recognize and compensate the low-coherence area,GB-InSAR,interferometric phase feature
更新于2025-09-23 15:22:29