Visualization of carboxylesterase 2 with a near-infrared two-photon fluorescent probe and its potential evaluation of anticancer drug effects in orthotopic colon carcinoma mice model

摘要： We establish a near-infrared two-photon fluorescent probe for the detection of CE2 with high selectivity and sensitivity. This probe exhibits low cytotoxicity and superior tissue penetration ability for evaluating real-time activity of CE2 in living cells, in cancer tissues, and in colon carcinoma mice model.