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New Frontiers: An Update on Computer-Aided Diagnosis for Breast Imaging in the Age of Artificial Intelligence
摘要： OBJECTIVE. The purpose of this article is to compare traditional versus machine learning–based computer-aided detection (CAD) platforms in breast imaging with a focus on mammography, to underscore limitations of traditional CAD, and to highlight potential solutions in new CAD systems under development for the future. CONCLUSION. CAD development for breast imaging is undergoing a paradigm shift based on vast improvement of computing power and rapid emergence of advanced deep learning algorithms, heralding new systems that may hold real potential to improve clinical care.
关键词： computer-aided detection,breast,artificial intelligence,mammography,texture analysis,computer-aided diagnosis
更新于2025-09-19 17:15:36
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Automatic Computer-Aided Diagnosis of Retinal Nerve Fiber Layer Defects Using Fundus Photographs in Optic Neuropathy
摘要： PURPOSE. To evaluate the validity of an automatic computer-aided diagnosis (CAD) system for detection of retinal nerve fiber layer (RNFL) defects on fundus photographs of glaucomatous and nonglaucomatous optic neuropathy. METHODS. We have proposed an automatic detection method for RNFL defects on fundus photographs in various cases of glaucomatous and nonglaucomatous optic neuropathy. In order to detect the vertical dark bands as candidate RNFL defects, the nonuniform illumination of the fundus image was corrected, the blood vessels were removed, and the images were converted to polar coordinates with the center of the optic disc. False positives (FPs) were reduced by using knowledge-based rules. The sensitivity and FP rates for all images were calculated. RESULTS. We tested 98 fundus photographs with 140 RNFL defects and 100 fundus photographs of healthy normal subjects. The proposed method achieved a sensitivity of 90% and a 0.67 FP rate per image and worked well with RNFL defects with variable depths and widths, with uniformly high detection rates regardless of the angular widths of the RNFL defects. The average detection accuracy was approximately 0.94. The overall diagnostic accuracy of the proposed algorithm for detecting RNFL defects among 98 patients and 100 healthy individuals was 86% sensitivity and 75% specificity. CONCLUSIONS. The proposed CAD system successfully detected RNFL defects in optic neuropathies. Thus, the proposed algorithm is useful for the detection of RNFL defects.
关键词： computer-aided diagnosis,glaucoma,optic neuropathy,fundus photographs,retinal nerve fiber layer
更新于2025-09-19 17:15:36
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A fully automated pipeline of extracting biomarkers to quantify vascular changes in retina-related diseases
摘要： This paper presents an automated system for extracting retinal vascular biomarkers for early detection of diabetes. The proposed retinal vessel enhancement, segmentation, optic disc (OD) and fovea detection algorithms provide fundamental tools for extracting the vascular network within the pre-defined region of interest. Based on that, the artery/vein classification, vessel width, tortuosity and fractal dimension measurement tools are used to assess a large number of quantitative vascular biomarkers. We evaluate our pipeline module by module against human annotations. The results indicate that our automated system is robust to the localisation of OD and fovea, segmentation of vessels and classification of arteries/veins. The proposed pipeline helps to increase the effectiveness of the biomarkers extraction and analysis for the early diabetes, and therefore, has the large potential of being further incorporated into a computer-aided diagnosis system.
关键词： diabetes,Retinal image analysis,vessel biomarkers,computer-aided diagnosis
更新于2025-09-19 17:15:36
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Optimal planar X-ray imaging soft tissue segmentation using a photon counting detector
摘要： A rigorous method for automated soft tissue segmentation using planar kilovoltage (kV) imaging, a photon counting detector (PCD), and a convolutional neural network is presented. The goal of the project was to determine the optimum number of energy bins in a PCD for soft tissue segmentation. Planar kV X-ray images of solid water (SW) phantoms with varying depth of cartilage were generated with a cone-beam analytical method and parallel-beam Monte Carlo simulations. Simulations were preformed using 2 to 5 PCD energy bins with equal photon fluence distribution. Simulated image signal to noise ratio (SNR) was varied between 10 to 250 measured after transmission through 4 cm of SW. Algorithms using non-linear as well as linear regression were used to predict the amount of cartilage for every pixel of the phantom. These algorithms were evaluated based on the mean squared error (MSE) between their prediction and the ground truth. The best algorithm was used to decompose randomly generated SW and cartilage images with an SNR of 100. These randomly generated images trained a U-Net convolutional neural network to segment the cartilage in the image. The results indicated the smallest MSE occurred for non-linear regression with 4 energy bins over all SNR. The trained U-Net was able to correctly segment all regions of cartilage for the smallest amount of cartilage used (4 mm) and segmented the region with > 99% categorical accuracy by pixel.
关键词： X-ray radiography and digital radiography (DR),Medical-image reconstruction methods and algorithms,computer-aided diagnosis
更新于2025-09-19 17:15:36
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[IEEE 2018 IEEE/ACS 15th International Conference on Computer Systems and Applications (AICCSA) - Aqaba, Jordan (2018.10.28-2018.11.1)] 2018 IEEE/ACS 15th International Conference on Computer Systems and Applications (AICCSA) - Number of Texture Unit as Feature to Breast's Disease Classification from Thermal Images
摘要： This paper presents the use of the Number of Texture Unit as a feature extractor for classification of breast images. The Number of Texture Unit served as the basis for the idealization of the Local Binary Pattern a technique that is widely used in facial recognition. We compared the proposed strategy with the Gray Level Co-occurrence Matrix which is the most used texture analysis technique in the literature. With this work we have been able to show that the combination of the two techniques of feature extraction improves the final result of classification. To perform the tests we used the Support Vectors Machine classifier and obtained a result of 96.15% Area Under the Curve (Receiver Operating Characteristic Curve).
关键词： computer aided diagnosis,machine learning,support vector machine,feature extraction,infrared images,Local Binary Pattern
更新于2025-09-19 17:15:36
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A Decision Support Tool For Early Detection of Knee OsteoArthritis using X-ray Imaging and Machine Learning: Data from the OsteoArthritis Initiative
摘要： This paper presents a fully developed computer aided diagnosis (CAD) system for early knee OsteoArthritis (OA) detection using knee X-ray imaging and machine learning algorithms. The X-ray images are first preprocessed in the Fourier domain using a circular Fourier filter. Then, a novel normalization method based on predictive modeling using multivariate linear regression (MLR) is applied to the data in order to reduce the variability between OA and healthy subjects. At the feature selection/extraction stage, independent component analysis (ICA) is used in order to reduce the dimensionality. Finally, Naive Bayes and random forest classifiers are used for the classification task. This novel image-based approach is applied on 1024 knee X-ray images from the public database OsteoArthritis Initiative (OAI). The results show that the proposed system has a good predictive classification rate for OA detection (82.98 % for accuracy, 87.15 % for sensitivity and up to 80.65 % for specificity).
关键词： Computer Aided diagnosis System,Intensity Normalization,Classification,OsteoArthritis
更新于2025-09-19 17:15:36
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[SPIE Computer-Aided Diagnosis - Houston, United States (2018.2.10-2018.2.15)] Medical Imaging 2018: Computer-Aided Diagnosis - Convolutional neural networks for the detection of diseased hearts using CT images and left atrium patches
摘要： Cardiovascular disease is a leading cause of death in the United States. The identification of cardiac diseases on conventional three-dimensional (3D) CT can have many clinical applications. An automated method that can distinguish between healthy and diseased hearts could improve diagnostic speed and accuracy when the only modality available is conventional 3D CT. In this work, we proposed and implemented convolutional neural networks (CNNs) to identify diseased hearts on CT images. Six patients with healthy hearts and six with previous cardiovascular disease events received chest CT. After the left atrium for each heart was segmented, 2D and 3D patches were created. A subset of the patches were then used to train separate convolutional neural networks using leave-one-out cross-validation of patient pairs. The results of the two neural networks were compared, with 3D patches producing the higher testing accuracy. The full list of 3D patches from the left atrium was then classified using the optimal 3D CNN model, and the receiver operating curves (ROCs) were produced. The final average area under the curve (AUC) from the ROC curves was 0.840 ± 0.065 and the average accuracy was 78.9% ± 5.9%. This demonstrates that the CNN-based method is capable of distinguishing healthy hearts from those with previous cardiovascular disease.
关键词： Deep learning,Heart disease,Classification,Cardiovascular disease (CVD),Convolutional neural networks,Computer-aided diagnosis,3D Computed tomography
更新于2025-09-19 17:15:36
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Artificial intelligence for magnifying endoscopy, endocytoscopy, and confocal laser endomicroscopy of the colorectum
摘要： Because magnifying endoscopy is considered to be more accurate at predicting the histology of colorectal polyps than non-magnifying endoscopy, it has been attracting a lot of attention, especially in Japan. However, use of magnifying endoscopy is not yet widespread because of its limited availability and the difficulty in interpreting the acquired images. Application of artificial intelligence (AI) is now changing this situation because it helps less skilled endoscopists to accurately interpret magnified images. Research in this field initially focused on magnifying endoscopy with narrow-band imaging as the target of AI. Most previously published retrospective studies have reported over 90% sensitivity in differentiation of neoplastic lesions; however, automatically indicating the region of interest (ROI) of the polyps that AI should analyze has been found to be challenging. To address this practical problem, some researchers have started to adopt contact endomicroscopy as a target for AI. Contact endomicroscopy includes endocytoscopy (520-fold magnification, Olympus, Tokyo, Japan) and confocal laser endomicroscopy (1000-fold magnification, Mauna Kea, Paris, France). These forms of contact endomicroscopy provide ultra-magnified images that make it unnecessary to manually select the ROI because the entire image acquired by contact endomicroscopy is the ROI of the targeted polyps. This strength of contact endomicroscopy has contributed to early implementation of this technology into clinical practice, which may change the utility of magnifying endoscopy in clinical settings and help increase its use globally in the near future.
关键词： Colonoscopy,Computer aided diagnosis,cancer,polyp,Characterization
更新于2025-09-19 17:13:59
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An Ultra-Wideband Power Combining in Ridge Waveguide for Millimeter Wave
摘要： Valid characterization of carotid atherosclerosis (CA) is a crucial public health issue, which would limit the major risks held by CA for both patient safety and state economies. This paper investigated the unexplored potential of kinematic features in assisting the diagnostic decision for CA in the framework of a computer-aided diagnosis (CAD) tool. To this end, 15 CAD schemes were designed and were fed with a wide variety of kinematic features of the atherosclerotic plaque and the arterial wall adjacent to the plaque for 56 patients from two different hospitals. The CAD schemes were benchmarked in terms of their ability to discriminate between symptomatic and asymptomatic patients and the combination of the Fisher discriminant ratio, as a feature-selection strategy, and support vector machines, in the classification module, was revealed as the optimal motion-based CAD tool. The particular CAD tool was evaluated with several cross-validation strategies and yielded higher than 88% classification accuracy; the texture-based CAD performance in the same dataset was 80%. The incorporation of kinematic features of the arterial wall in CAD seems to have a particularly favorable impact on the performance of image-data-driven diagnosis for CA, which remains to be further elucidated in future prospective studies on large datasets.
关键词： motion analysis,Carotid atherosclerosis (CA),kinematic features,ultrasound (US),computer-aided diagnosis (CAD)
更新于2025-09-19 17:13:59
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Microscopy and Analysis || Automatic Interpretation of Melanocytic Images in Confocal Laser Scanning Microscopy
摘要： The frequency of melanoma doubles every 20 years. The early detection of malignant changes augments the therapy success. Confocal laser scanning microscopy (CLSM) enables the noninvasive examination of skin tissue. To diminish the need for training and to improve diagnostic accuracy, computer-aided diagnostic systems are required. Two approaches are presented: a multiresolution analysis and an approach based on deep layer convolutional neural networks. For the diagnosis of the CLSM views, architectural structures such as micro-anatomic structures and cell nests are used as guidelines by the dermatologists. Features based on the wavelet transform enable an exploration of architectural structures at different spatial scales. The subjective diagnostic criteria are objectively reproduced. A tree-based machine-learning algorithm captures the decision structure explicitly and the decision steps are used as diagnostic rules. Deep layer neural networks require no a priori domain knowledge. They are capable of learning their own discriminatory features through the direct analysis of image data. However, deep layer neural networks require large amounts of processing power to learn. Therefore, modern neural network training is performed using graphics cards, which typically possess many hundreds of small, modestly powerful cores that calculate massively in parallel. Readers will learn how to apply multiresolution analysis and modern deep learning neural network techniques to medical image analysis problems.
关键词： convolutional neural networks,skin lesions,multiresolution image analysis,computer-aided diagnosis,confocal laser scanning microscopy,machine learning
更新于2025-09-19 17:13:59