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Intrastromal crosslinking in post-LASIK ectasia
摘要： We describe a case of early post-LASIK ectasia detected in the first 6 months after surgery. The patient was treated by means of intrastromal corneal crosslinking under the flap, without de-epithelialization, which resulted in a positive outcome. At the time of writing, 2 years after the procedure, the patient remained free of progression.
关键词： Keratomileusis, laser in situ,Adult,Case reports,Corneal wavefront aberrations,Corneal stroma,Astigmatism,Postoperative complications,Cross-linking reagent,Refractive surgical procedures,Humans,Female
更新于2025-09-09 09:28:46
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Second Harmonic Generation Imaging Analysis of Collagen Arrangement in Human Cornea
摘要： PURPOSE. To describe the horizontal arrangement of human corneal collagen bundles by using second harmonic generation (SHG) imaging. METHODS. Human corneas were imaged with an inverted two photon excitation ?uorescence microscope. The excitation laser (Ti:Sapphire) was tuned to 850 nm. Backscatter signals of SHG were collected through a 425/30-nm bandpass emission ?lter. Multiple, consecutive, and overlapping image stacks (z-stacks) were acquired to generate three dimensional data sets. ImageJ software was used to analyze the arrangement pattern (irregularity) of collagen bundles at each image plane. RESULTS. Collagen bundles in the corneal lamellae demonstrated a complex layout merging and splitting within a single lamellar plane. The patterns were signi?cantly different in the super?cial and limbal cornea when compared with deep and central regions. Collagen bundles were smaller in the super?cial layer and larger in deep lamellae. CONCLUSIONS. By using SHG imaging, the horizontal arrangement of corneal collagen bundles was elucidated at different depths and focal regions of the human cornea.
关键词： collagen,corneal stroma,second harmonic generation,cornea
更新于2025-09-09 09:28:46