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Dual-responsive doxorubicin-conjugated polymeric micelles with aggregation-induced emission active bioimaging and charge conversion for cancer therapy
摘要： In recent years, intelligent polymeric micelles with multi-functions are in urgent demand for cancer diagnosis and therapy. Herein, pH and redox dual-responsive prodrug micelles with aggregation-induced emission (AIE) active cellular imaging and charge conversion have been prepared for combined chemotherapy and bioimaging based on a novel doxorubicin-conjugated amphiphilic PMPC-PAEMA-P (TPE-co-HD)-ss-P (TPE-co-HD)-PAEMA-PMPC copolymer. The doxorubicin is conjugated via a pH cleavable imine linkage and can be packed in the hydrophobic core along with the glutathione (GSH)-sensitive disulfide bond. The DOX-conjugated inner core is sealed with a pH-responsive PAEMA as the “gate”, which would rapidly open in the acidic condition, following the drug release and charge conversion-mediated acceleration of endocytosis. After an efficient internalization, the disulfide bond can be cleaved by the high concentration of GSH causing the further accelerated drug release. Meanwhile, intracellular drug delivery can be traced due to the AIE behavior of micelles. Moreover, great tumor inhibition in vitro and in vivo has been demonstrated for these DOX-conjugated micelles. This smart prodrug micelle system would be a desirable drug carrier for cancer therapy and bioimaging.
关键词： polymeric micelles,charge conversion,aggregation-induced emission,dual-responsive,cancer therapy
更新于2025-09-23 15:21:21
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Macroscopic Au@PANI Core/shell Nanoparticle Superlattice Monolayer Film with Dual-responsive Plasmonic Switches
摘要： The self-assembled gold nanoparticles superlattice displays unusual but distinctive features such as highly mechanical and free-standing performance, electrical conductivity and plasmonic properties, which were widely employed in various applications especially in biological diagnostics and optoelectronic devices. Two-dimensional (2D) superlattice monolayer film composed of a given metal nanostructure, it is rather challenging to tune either its plasmonic properties or its optical properties in a reversible way, and it is not reported. It is therefore of significant value to construct free-standing 2D superlattice monolayer film of gold nanoparticles with intelligent response and desired functions. Herein, we developed an easy and efficient approach to construct gold nanoparticles superlattice film with a dual-responsive plasmonic switch. In this system, gold nanoparticles were firstly coated by polyaniline (PANI), and then interracially self-assembled into monolayer film at the air-liquid interface. PANI shell plays two important roles in superlattice monolayer film. Firstly, PANI shell acts as a physical spacer to provide a steric hindrance to counteract the van der Waals (vdWs) attraction between densely packed nanoparticles (NPs), resulting in the formation of superlattice by adjusting the thickness of the PANI shell. Secondly, PANI shells provide superlattice film with multiple stimuli such as electrical potential and pH change, leading to reversible optical and plasmonic responsive. Superlattice monolayer film can show a vivid color change from olive green to pink, or from olive green to violet by the change of corresponding stimuli. And the localized surface plasmonic resonance (LSPR) of superlattice monolayer film can be reversibly modulated by changing both local pH and applying electric potential. Notably, a significant plasmonic shift of superlattice monolayer film can be achieved to 157 nm, when PANI shell with the thickness of 35 nm and gold nanorods as core were used. The superlattice monolayer film with dual-responsive plasmonic switches is promising for a range of potential applications in optoelectronic devices, plasmonic and colorimetric sensors, and Surface enhanced Raman scattering (SERS).
关键词： plasmonic switching,dual-responsive,superlattice,2D monolayer film,core shell structure
更新于2025-09-19 17:13:59
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A novel luminescent 1D→2D polyrotaxane Zn(II)-organic framework showing dual responsive fluorescence sensing for Fe3+ cation and Cr(VI) anions in aqueous medium
摘要： A novel hydrolytic stable Zn(II)-organic framework {[Zn(afsba)(bbtz)1.5(H2O)2]·2H2O}n (1) based on the amino/sulfonato-functionalized ligand 2-amino-5-sulfobenzoic acid (H2afsba) and the auxiliary flexible ligand 1, 4-bis(triazol-1-ylmethyl)benzene (bbtz) was constructed hydrothermally. Single-crystal X-ray diffraction analysis reveals that 1 shows a novel 1D→2D polyrotaxane framework architecture. The detailed analysis of the solid state diffuse reflectance UV-vis spectrum of 1 reveals that it may be used as a potential wide band gap semiconductor material. 1 exhibits reversible dehydration-rehydration behavior. 1 manifests distinct solvent-dependent fluorescence properties. The strongest fluorescence is observed in water. 1 keeps excellent framework stability in a variety of solvents. Interstingly, 1 shows highly selective and efficient sensing of the Fe3+ cations over a variety of the interfering metal cations in both environment and biological systems. 1 could also be used as a potential highly selective and sensitive sensory material for the Cr(VI) (CrO4 2?/Cr2O7 2?) anions among a large pool of the coexistent different anions. The limits of 1 for the aqueous-phase sensing of these analytes reach to sub-ppm level (0.22 ppm/0.26 ppm for CrO4 2?/Cr2O7 2- and 0.07 ppm for Fe3+, respectively).
关键词： dual responsive fluorescence sensing,Fe3+ cation,Zn(II)-organic polyrotaxane framework,Cr(VI) anions
更新于2025-09-10 09:29:36
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Intrinsically Porous Dual-Responsive Polydiacetylenes Based on Tetrahedral Diacetylenes
摘要： The combinatorial functionalization in a single molecular framework by structural integration utilizing multiple functional materials to create prede?ned structural morphology and multistimuli-responsive smart materials has attracted intensive attention. Herein, we constructed intrinsically porous and dual-responsive supramolecule, TeDA, by introducing a photopolymerizable diacetylene template (10,12-pentacosadiynoic acid) to the sterically rigid tetrahedral tetraphenylmethane (TPM) core. The self-assembled monomeric TeDA is transformed into the covalently cross-linked blue-phase polydiacetylene (TePDA) by UV irradiation (UV 254 nm). The BET measurement and examination of SEM images con?rm the mesoporous characteristic for TeDA/PDA. Very interestingly, the blue-phase TePDA produces a naked-eye detectable colorimetric response to heat and VOCs (liquid and vapor phase). Most importantly, TePDA exhibits reversible thermochromism and excellent colorimetric response to chloroform vapors. To signify the structural in?uence of TPM on material properties, we also studied non-TPM derivatives. The TeDA/PDA integrated system demonstrates potential applications in developing multistimuli-responsive sensors.
关键词： dual-responsive,porous,thermochromism,VOCs detection,colorimetric response,polydiacetylenes,tetrahedral diacetylenes
更新于2025-09-04 15:30:14