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Ablative fractional laser‐assisted photodynamic therapy for lentigo maligna: a prospective pilot study
摘要： Background Lentigo maligna (LM) is an in situ form of melanoma carrying a risk of progression to invasive lentigo maligna melanoma (LMM). LM poses a clinical challenge, with subclinical extension and high recurrence rates after incomplete surgery. Alternative treatment methods have been investigated with varying results. Photodynamic therapy (PDT) with methylaminolaevulinate (MAL) has already proved promising in this respect. Objectives To investigate the efficacy of ablative fractional laser (AFL)-assisted PDT with 5-aminolaevulinic acid nanoemulsion (BF-200 ALA) for treating LM. Methods In this non-sponsored prospective pilot study, ten histologically verified LMs were treated with AFL-assisted PDT three times at 2-week intervals using a light dose of 90 J/cm2 per treatment session. Local anaesthesia with ropivacaine was used. Four weeks after the last PDT treatment the lesions were treated surgically with a wide excision and sent for histopathological examination. The primary outcome was complete histopathological clearance of the LM from the surgical specimen. Patient-reported pain during illumination and the severity of the skin reaction after the PDT treatments were monitored as secondary outcomes. Results The complete histopathological clearance rate was 7 out of 10 LMs (70%). The pain during illumination was tolerable, with the mean pain scores for the PDT sessions on a visual assessment scale ranging from 2.9 to 3.8. Some severe skin reactions occurred during the treatment period, however. Conclusions Ablative fractional laser-assisted PDT showed moderate efficacy in terms of histological clearance. It could constitute an alternative treatment for LM but due to the side effects it should only be considered in inoperable cases.
关键词： Histopathological clearance,5-aminolaevulinic acid,Ablative fractional laser,Photodynamic therapy,Lentigo maligna
更新于2025-09-11 14:15:04
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The effect of 1540‐nm fractional erbium‐glass laser in the treatment of androgenic alopecia
摘要： Background: Androgenic alopecia is common, chronic dermatologic disorder. A variety of lasers and light sources appear to be safe and effective in the treatment of AGA. Aims: To evaluate the efficacy and safety of 1540‐nm fractional erbium glass laser in the treatment of AGA. Patients/Methods: This was an interventional therapeutic study for the treatment of patients with AGA. The patients received 10 sessions with 1540‐nm fractional erbium glass laser at 2‐week intervals. The assessment of the response was done before and at the end of follow‐up period, both objectively (the change in the density of terminal hair and the diameter of the hair shaft) and subjectively (patient satisfaction). Any adverse effects were documented during the study. Results: Forty‐seven out of 51 patients completed the study. After 5 months of laser treatment, the density of hair and hair thickness was significantly increased in both males and females (P value .001). Conclusion: The 1540‐nm fractional erbium‐glass laser seems to be an effective and safe option for treatment of patients with AGA. The improvement was accomplished in a short period.
关键词： fractional,laser,1540 nm,androgenic alopecia,erbium‐glass
更新于2025-09-11 14:15:04