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Retinal vascular density evaluated by optical coherence tomography angiography in macular telangiectasia type 2
摘要： Purpose To evaluate the retinal and choroidal vascular changes through optical coherence tomography angiography (OCTA) in patients with macular telangiectasia type 2 (MacTel 2). Methods Our study included 20 patients (40 eyes) with MacTel 2, and age-matched and sex-matched 18 subjects (36 eyes) in the control group. Fundus color photographs, fundus autofluorescence, fundus fluorescein angiography, spectral-domain optical coherence tomography and OCTA were performed. Foveal vascular density and parafoveal vascular density (PFVD), and foveal retinal thickness and parafoveal retinal thickness, choroidal thickness (CT) and retinal ganglion cell–inner plexiform layer (GCIPL) were compared between MacTel 2 patients and normal age-matched controls. Results The retinal whole vascular density and PFVD of the deep plexus were significantly lower in patients with MacTel 2 than that of the control group (56.93% vs. 58.54%, p = 0.003; and 60.38% vs. 61.66%, p = 0.045). The foveal avascular zone (FAZ) of the deep plexus was significantly enlarged in patients with MacTel 2 than that of the control group (0.44 vs. 0.36, p = 0.009). There was a positive and statistically significant correlation between the FAZ of the superficial and deep plexus and CT in patients with MacTel 2. There was a positive and statistically significant correlation between retinal whole, parafoveal temporal quadrant vascular density of the superficial and deep plexus and GCIPL thickness in patients with MacTel 2. Conclusions Our study demonstrated that important retinal vascular density and FAZ changes in MacTel 2 occur in the deep capillary plexus of the retina.
关键词： Macular telangiectasia type 2,Vascular density,Choroidal thickness,Retinal ganglion cell–inner plexiform layer,Optical coherence tomography angiography
更新于2025-09-23 15:23:52
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Structure–Function Relationship in Glaucoma Using Ganglion Cell–Inner Plexiform Layer Thickness Measurements
摘要： PURPOSE. To evaluate the structure–function relationship between ganglion cell–inner plexiform layer (GCIPL) thickness at the macula and 10-2 standard automated perimetry (SAP) in glaucoma and to evaluate the relationship using a recently proposed linear model. METHODS. In a cross-sectional analysis, structure–function relationship was determined in 50 glaucomatous eyes (40 patients, mean deviation: (cid:2)15.4 6 7.5 dB) and 21 control eyes (13 subjects, mean deviation: (cid:2)3.4 6 3.0 dB), which had undergone 10-2 SAP and GCIPL imaging on the same day. Functional loss was derived from total deviation numerical values on 10-2 SAP and calculated on both a linear (reciprocal of Lambert) and a decibel scale after accounting for the retinal ganglion cell displacement at the macula. Strength of relationship was reported as coef?cient of determination (R2) of the linear regression models ?tted to the data separately for different sectors. The relationship was also evaluated using a linear model. RESULTS. The R2 for the associations between GCIPL thickness sectors and the corresponding sector SAP total deviation values ranged from 0.19 (for superonasal GCIPL sector) to 0.60 (for average GCIPL thickness) when functional loss was calculated on the decibel scale and 0.16 (for superonasal sector) to 0.54 (for inferior sector) on the linear scale. All associations were statistically signi?cant (P < 0.05). The linear model ?tted the data reasonably well. CONCLUSIONS. Signi?cant structure–function associations were found between GCIPL thickness measurements at the macula and the functional loss measured on 10-2 SAP in glaucoma. Best ?t was found for the inferior and average GCIPL sector thickness. The linear model was useful to study the structure–function relationship.
关键词： visual ?eld,ganglion cell–inner plexiform layer,glaucoma,structure–function relationship
更新于2025-09-11 14:15:04
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Assessment of macular ganglion cell complex using optical coherence tomography: Impact of a paediatric reference database in clinical practice
摘要： Importance: Optical coherence tomography software classifies abnormality of macular ganglion cell-inner plexiform layer thickness and macular retinal nerve fibre layer thickness based on adult series. Background: We assessed the impact of using paediatric reference macular ganglion cell complex values instead of adult reference values. Design: Cross-sectional study. Primary and tertiary health-care setting. Participants: Out of 140 healthy participants aged 5 to 18 years, 90% were eligible. Methods: Following a dilated eye examination and cycloplegic refraction, participants underwent optical coherence tomography ganglion cell scans (Topcon 3D OCT-2000; Topcon Corporation, Tokyo, Japan). Right eye measurements for superior, inferior, and total layer thickness and spherical equivalent were reported, together with age, sex and origin. Main Outcome Measures: Paediatric reference values by age and spherical equivalent were produced, and the specific agreement between paediatric and adult to percentile 5 was ganglion cell complex reference values below or equal estimated. Results: The multivariate analysis confirmed a positive association between spherical equivalent and macular ganglion cell-inner plexiform layer thickness, and between age and macular retinal nerve fibre layer (five out of six regression coefficients P values were (cid:1) 0.03). Specific agreement was 25% for ganglion cell-inner plexiform layer thickness and > 80% for macular retinal nerve fibre layer. Adult-based software identified low ganglion cell values in one in seven children compared to paediatric reference values (0.8% vs 5.5%, P = 0.031). Conclusions and Relevance: The availability of optical coherence tomography ganglion cell complex reference values for paediatric age and spherical equivalent groups can be used to improve detection of children with low cell layer thickness.
关键词： macular ganglion cell-inner plexiform layer,childhood,optical coherence tomography,children reference database,retinal ganglion cells,macular retinal nerve fibre layer,ganglion cell complex
更新于2025-09-10 09:29:36
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Changes in Ganglion Cell-Inner Plexiform Layer Thickness and Retinal Microvasculature in Hypertension: An OCT Angiography Study
摘要： Objective: To investigate retinal blood flow in patients with hypertension using optical coherence tomography angiography (OCTA) and the relationship between blood flow metrics and ganglion cell-inner plexiform layer (GC-IPL) thickness. Design: Retrospective, cross-sectional study. Methods: A total of 201 eyes from 117 healthy subjects and 84 hypertensive patients without any ocular abnormalities were included. Hypertensive patients were divided into the two groups according to disease periods (<5 years: hypertension group 1; ≥5 years: hypertension group 2). Macular 3 × 3 mm angiography was acquired using the Zeiss Cirrus 5000 OCT instrument. Vessel density (VD), perfusion density (PD), and foveal avascular zone metrics of the superficial capillary plexus were automatically calculated, and the thicknesses of the central fovea, GC-IPL, and peripapillary retinal nerve fiber layer (RNFL) were measured. All measurements were compared among the three groups, and retinal blood flow metrics were correlated with the thickness of each retinal layer. Logistic regression analyses were performed to determine the factors associated with prolonged hypertension. Results: The average GC-IPL (p<0.001) and peripapillary RNFL (p=0.048) thicknesses in hypertension group 2 were significantly thinner compared to the control group. The 3 mm total area of the VD and PD was also decreased compared to the control group and hypertension group 1 (all p<0.05), and was significantly correlated with the GC-IPL (VD: r=0.450, p=0.001; PD: r=0.467, p<0.001) and peripapillary RNFL (VD: r=0.314, p=0.027; PD: r=0.328, p=0.023) thicknesses in hypertension group 2. Using multivariate logistic analyses, only the average GC-IPL thickness was a significant factor for prolonged hypertension (odds ratio=0.911, p=0.002). Conclusions: In patients with hypertension lasting more than 5 years, inner retinal layer thinning, particularly GC-IPL thinning, was observed, which was significantly correlated with a decrease in retinal blood flow. Therefore, physicians should consider the effects of hypertension on the GC-IPL.
关键词： hypertension,retinal microcirculation,optical coherence tomography angiography,ganglion cell-inner plexiform layer
更新于2025-09-09 09:28:46
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Spectral-Domain Optical Coherence Tomography Features in Open-Angle Glaucoma With Diabetes Mellitus and Inadequate Glycemic Control
摘要： PURPOSE. To evaluate spectral-domain optical coherence tomography (SD-OCT) features according to glycemic control status in open-angle glaucoma with diabetes mellitus. METHODS. Subjects underwent comprehensive ocular examination, visual ?eld testing, and SD-OCT imaging (Cirrus HD-OCT). The relationship between glycosylated hemoglobin (HbA1c) and OCT measurements was compared between diabetic nonglaucomatous eyes and diabetic glaucomatous eyes. Glaucoma-discriminating ability was assessed using the area under the receiver operating characteristic curves (AUCs) for OCT parameters and compared between groups relative to the glycemic control group. RESULTS. Analysis was performed on 69 nonglaucomatous and 87 glaucomatous eyes in the nondiabetic group, and on 72 nonglaucomatous and 56 glaucomatous eyes in the diabetic group. Average, inferonasal, inferior, and inferotemporal ganglion cell–inner plexiform layer (GCIPL) thicknesses were positively correlated with HbA1c in diabetic nonglaucomatous eyes (P ? 0.040, 0.037, 0.025, and 0.013, respectively). The AUC of the average cup-to-disc area ratio (CDR), vertical CDR, and cup volume in diabetic eyes with poor glycemic control was signi?cantly higher than those in nondiabetic eyes (P ? 0.011, 0.003, and 0.043, respectively). The AUC of cube volume, cube average thickness, and minimal GCIPL thickness in diabetic eyes with poor glycemic control was lower than those in nondiabetic eyes (P ? 0.006, 0.007, and 0.004, respectively). CONCLUSIONS. In this study, optic nerve head parameters had a superior ability to discriminate glaucoma in diabetic eyes with poor glycemic control. Conversely, the ability to discriminate glaucoma using macular parameters tended to be lower for diabetic eyes with inadequate glycemic control.
关键词： spectral-domain optical coherence tomography,diabetes mellitus,ganglion cell-inner plexiform layer,glaucoma
更新于2025-09-04 15:30:14