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Evaluation of Safety and Efficacy of Laser Hair Removal With the Long‐Pulsed 755?nm Wavelength Laser: A Two‐Center Study With 948 Patients
摘要： Background and Objectives: Laser hair removal is the most common laser therapy and the third most commonly performed procedure with more than one million treatments in United States in 2016. This retrospective study was conducted to assess long‐term efficacy and safety of the 755 nm laser for hair removal. Study Design/Materials and Methods: Nearly, 3,606 laser treatments were performed with the long‐pulsed 755 nm wavelength laser equipped with an epidermal cooling device between 1997 and 2005 and were followed till 2013. Standardized assessments were conducted by two treating physicians and patients at two follow‐up intervals. At first follow‐up, clearance was assessed by two physicians and clearance and satisfaction by patients. At the second follow‐up, patients were assessed if hair clearance sustained compared with the first follow‐up. Results: Nine hundred and forty‐eight patients with Fitzpatrick skin types I–IV were treated with a total of 3,606 laser treatments in this study. The mean age at the beginning of the study was 35 years (±11), 95.1% of patients were female (n = 902) and 4.9% male (n = 46). Five hundred and seventy‐four patients received a minimum of three treatments and an average of 5.31 (3–16) treatments on axilla, back, bikini, breast, abdomen, face, lower extremity, or upper extremity region. First, follow‐up was conducted 3.9 (±1.5) years after the laser treatment. Seventy‐four percent of these final patients received 75–100% clearance as reported by the physician and 48% clearance as reported by the patient. Fifty‐two percent of patients reported slower hair growth and 42% change in hair texture. Ninety percent of patients treated on axilla, 82% treated on the bikini area, and 79% treated on lower extremities experienced 75% or more clearance after three treatments. Facial, as well as breast and abdomen treatments, only showed a 66% and 62%, respectively, after three treatments. For these locations, five and more treatments were needed to achieve a quote of 79% (face) or 80% (breast and abdomen) for a 75–100% clearance. Upper extremity and back treatments did not have enough physician ratings to draw conclusions. Long‐term adverse events were minimal and were all located on the face (one patient scar, four patients herpes infection). Second follow‐up of 173 patients was conducted after 11.5 years (±2.0) and 87.9% of patients reported that their improvement sustained. Conclusions: The long‐pulsed 755 nm alexandrite laser is a safe and efficacious treatment for the reduction of unwanted body hair with permanent results and high patient satisfaction.
关键词： laser,alexandrite,hypertrichosis,clearance,hair removal
更新于2025-09-11 14:15:04
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Lasers for Reduction of Unwanted Hair in Skin of Color: A Systematic Review and Meta‐analysis
摘要： Light-based therapies are one of the most effective and widely used strategies for removal of undesired hair, with a broadly favorable safety profile. However, subjects with pigmented skin are found to be more prone to laser-related adverse events. While prolonged pulse-width and longer treatment duration were proposed to minimize adverse events, the optimal treatment option among available phototherapy modalities—long-pulsed (Nd: YAG), pulsed diode, and alexandrite lasers as well as intense pulsed light (IPL)—remains unclear, particularly for skin of color. To determine superiority in terms of effectiveness and tolerability, we conducted a systematic review of literature on different types of in-office laser and IPL for hair removal in subjects with Fitzpatrick skin types III-VI. The meta-analysis was performed using Review Manager (RevMan) version 5.3 and included 12 eligible comparative trials (9 randomized controlled trials and 3 quasi-randomized). In terms of hair count reduction, pooled effect estimates for long-pulsed ND:YAG laser (OR 0.26, 95% CI [0.1, 0.78]) and diode laser (SMD -0.11, 95% CI [-0.62, 0.39) were not statistically significant from those of IPL; in contrast, alexandrite laser was found to be superior to IPL in reducing hair count (SMD -1.7, 95% CI [-2.6, -0.78]. In terms of adverse events, the pooled effect estimates favoured long‐pulsed Nd: YAG laser to IPL with respect to post-inflammatory hyperpigmentation (OR 0.26, 95% CI [0.1, 0.78]). However, both pulsed diode and alexandrite lasers exhibited a comparable safety profile to IPL, despite higher pain scores with lasers. In conclusion, this systematic review suggests that treatment outcomes for different in-office laser devices and IPL in subjects with skin type III-VI are broadly similar; nevertheless, we observed a trend toward greater hair reduction following laser therapy compared to IPL.
关键词： Hair removal,Dark skin,Intense pulsed light,Laser
更新于2025-09-11 14:15:04
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Dermoscopic evaluation of melanocytic nevi changes after photoepilation techniques: a prospective study
摘要： Background: The clinical and dermoscopic changes of melanocytic nevi under the effects of photo-epilation are poorly known. Objective: Prospective study on clinical and dermatoscopic effects of photoepilation on melanocytic nevi. Methods: Eighteen patients exposed to photo-epilation gave consent to a follow-up program from 2008 to 2017 at the Videodermatoscopic Office of the Dermatology Clinic of Cagliari (Italy), with clinical and dermoscopic assessment. Results: A mean 2-year follow-up was recorded for 73 lesions. The most frequent clinical change was nevi colour, clearer than basal pictures, sometimes with increased pigmentation at the periphery, or residual islands of pigmentation, with vanishing borders. Acute burn with crusting was noted in few cases. Only one case showed progressive growth. Corresponding dermoscopic findings were bleaching of nevi, followed by pigment network disruption, appearance of white structureless areas and grey-blue globules. Complete regression occurred in 32.8% of the lesions. The growing nevus was characterized by peripheral globules. Excision for histopathological examination showed a compound nevus with mild atypia. Conclusions: Although malignant modifications of nevi after photo-epilation have not been described, the clinical and dermoscopic changes we observed suggest to extend the follow for more than 24 months, as the potential long term adverse effects of photo-epilation on melanocytic nevi are unknown.
关键词： IPL,dermoscopy,laser,hair removal,photoepilation,melanocytic nevi changes
更新于2025-09-09 09:28:46