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[IEEE 2018 43rd International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz 2018) - Nagoya (2018.9.9-2018.9.14)] 2018 43rd International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz) - THz Near- Field Imaging and Spectroscopy with Nanoscale Resolution
摘要： Scattering-type near-field microscopy can overcome the limits in spatial resolution present in conventional THz imaging and spectroscopy techniques. This talk shows how THz near-field imaging and THz-TDS with a spatial resolution <20 nm can be realized with our neaSNOM microscope and some of the possible applications.
关键词： THz-TDS,nanoscale resolution,neaSNOM microscope,THz near-field imaging
更新于2025-09-04 15:30:14
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Recent advances in the synthesis of [ <i>a</i> ]-benzo-fused BODIPY fluorophores
摘要： This feature article summarizes the di?erent strategies for the synthesis of [a]-benzo-fused BODIPYs that have been reported in the literature until 2018. These p-extended BODIPYs are promising fluorophores for bio-imaging and organic photovoltaic applications due to both their attractive photophysical properties in the near-infrared area and their higher (photo)chemical stability compared to conventional bis-styryl derivatives. The four main strategies described in this review can be used to access either directly the expected [a]-benzo-fused BODIPYs or through the di-/tetra-hydroisoindole.
关键词： organic photovoltaic,fluorophores,near-infrared,BODIPY,bio-imaging
更新于2025-09-04 15:30:14
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Characterizing HR?3549?B using SPHERE
摘要： Aims. In this work, we characterize the low-mass companion of the A0 field star HR 3549. Methods. We observed HR 3549B in imaging mode with the near-infrared branch (IFS and IRDIS) of SPHERE at the VLT, with IFS in Y J mode and IRDIS in the H band. We also acquired a medium-resolution spectrum with the IRDIS long-slit spectroscopy mode. The data were reduced using the dedicated SPHERE GTO pipeline, which is custom-designed for this instrument. We employed algorithms such as PCA and TLOCI to reduce the speckle noise. Results. The companion was clearly visible with both IRDIS and IFS. We obtained photometry in four different bands and also the astrometric position for the companion. Based on our astrometry, we confirm that it is a bound object and set constraints on its orbit. Although several uncertainties still remain, we estimate an age of ～100–150 Myr for this system, yielding a most probable mass for the companion of 40–50 MJup and Teff ～ 2300?2400 K. Compared with template spectra, this points to a spectral type between M9 and L0 for the companion, commensurate with its position on the color–magnitude diagram.
关键词： techniques: imaging spectroscopy,planetary systems,methods: data analysis,instrumentation: spectrographs
更新于2025-09-04 15:30:14
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SAR Ground Moving Target Imaging Based on a New Range Model Using a Modified Keystone Transform
摘要： Imaging of a ground moving target (GMT) with synthetic aperture radar (SAR) is a challenging task, particularly when the Doppler ambiguity happens. This paper proposes a novel GMT range model and a novel Doppler ambiguity-tolerated GMT imaging algorithm based on modified keystone transform. In the proposed GMT range model, the range from radar antenna to the scattering center on the target is divided into two parts: the range from radar antenna to the target centroid and the projection length on the light of sight from the target centroid to the scattering center. Based on the new range model, a Doppler ambiguity-tolerated range cell migration correction (RCMC) method is proposed, in which keystone transform is modified to realize the differential RCMC by interpolation with nonzero phase sinc kernel. Finally, the GMT image is obtained in the range-Doppler domain by matched filtering in the slow-time domain and is restored into the 2-D space domain. The effectiveness of our proposed model and imaging method is demonstrated by both simulated and real airborne SAR data.
关键词： Ground moving target imaging (GMTIm),keystone transform,range cell migration correction (RCMC),range model,synthetic aperture radar (SAR)
更新于2025-09-04 15:30:14
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Ghost polarimetry: ghost imaging of polarization-sensitive objects
摘要： A new method of polarimetry which we have called ‘ghost polarimetry’ is suggested. The principle underlying the ghost imaging concept is generalized to polarization-sensitive objects which change the polarization state of incident light. Our theoretical model treats an object as a Jones matrix. In this approach, the information on the polarization properties of the object is contained in the elements of this matrix. We show that it is possible to connect the elements of Jones matrix with mutual correlation functions of the currents measured in the object arm and in two reference-arms where the signals in two orthogonal polarizations are registered. We demonstrate that the developed method allows to obtain polarization ghost image and therefore to identify the polarization structure of the object. Also it is shown that in order to implement this method the object should be illuminated by unpolarized incoherent light with Gaussian statistics. We believe that expanding the principle of ghost imaging to polarization sensitive objects will expand the diagnostic capabilities of existing polarimetry and ellipsometry technique.
关键词： ghost imaging,polarimetry,thermal light
更新于2025-09-04 15:30:14
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Metabolic Volumetric Parameters in <sup>11</sup> C-Choline PET/MR Are Superior PET Imaging Biomarkers for Primary High-Risk Prostate Cancer
摘要： Purpose. Positron emission tomography/magnetic resonance imaging (PET/MRI) can facilitate the use of noninvasive imaging biomarkers in clinical prostate cancer staging. Although multiparametric MRI is a widely used technique, the clinical value of simultaneous PET imaging remains unclear. This study aimed at investigating this issue. Methods. Between January 2015 and December 2016, 31 high-risk prostate cancer patients underwent 11C-choline PET/MRI for staging purposes. Clinical characteristics and imaging parameters, including the standardized uptake value (SUV) and metabolic volumetric parameters from PET imaging; apparent diffusion coefficient (ADC) values from diffusion-weighted imaging; and volume transfer rate constant (Ktrans), reflux rate constant (Kep), and initial area under curve (iAUC) in 60 seconds from dynamic contrast-enhanced (DCE) MRI were analyzed. Results. 11C-Choline PET imaging parameters were significantly correlated with prostate-specific antigen (PSA) levels, and metabolic volumetric parameters, including metabolic tumor volume (MTV) and uptake volume product (UVP), showed significant correlations with other MRI parameters. In our cohort analysis, the PET/MRI parameters UVP/minimal ADC value (ADCmin) and kurtosis of Kep (Kepkur)/ADCmin were significant predictors for progression-free survival (PFS) (HR = 1.01, 95% CI: 1.00–1.02, p = 0.031 and HR = 1.09, 95% CI: 1.02–1.16, p = 0.009, respectively) in multivariate Cox regression analysis. High UVP/ADCmin and Kepkur/ADCmin values were significantly associated with shorter PFS. Conclusions. Metabolic volumetric parameters such as MTV and UVP can be routinely used as PET imaging biomarkers to add prognostic value and show better correlations in combination with MR imaging parameters in high-risk prostate cancer patients undergoing 11C-choline PET/MRI.
关键词： 11C-choline,metabolic volumetric parameters,imaging biomarkers,PET/MRI,prostate cancer
更新于2025-09-04 15:30:14
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First In Vivo Use of High-Resolution Near-Infrared Optical Mapping to Assess Atrial Activation During Sinus Rhythm and Atrial Fibrillation in a Large Animal Model
摘要： Atrial fibrillation (AF) presents a serious health risk, but its mechanisms remain unclear because of the limited resolution, coverage, and surface-only recordings of multielectrode mapping. The advent of near-infrared optical mapping (NIOM) brought exciting opportunities for recording electrophysiological signals within the intramural heart wall in ex vivo animal studies and even blood-perfused hearts. Further application of high-resolution transmural NIOM in ex vivo human atria has been able to resolve intramural conduction to a depth of a few millimeters within the 3-dimensional human atrial wall during AF and circumvent the limitations of surface-only multielectrode mapping, providing a better understanding of AF. Thus, in vivo NIOM may aid in defining patient-specific arrhythmia mechanisms, thereby potentially enhancing targeted treatment. However, NIOM has not been performed in large animal models in vivo, a necessary first step.
关键词： atrial fibrillation,action potentials,voltage sensitive dye imaging,sinoatrial node,epicardial mapping
更新于2025-09-04 15:30:14
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[IEEE 2018 25th IEEE International Conference on Image Processing (ICIP) - Athens, Greece (2018.10.7-2018.10.10)] 2018 25th IEEE International Conference on Image Processing (ICIP) - Enabling Saccade Latency Measurements with Consumer-Grade Cameras
摘要： Eye movements can be affected by a number of neurological, neuromuscular, and neurodegenerative disorders that are important to diagnose and track longitudinally. To enable unobtrusive tracking of disease progression, we tailored and evaluated a set of candidate eye-tracking algorithms to operate on video sequences obtained from an iPhone 6, for accurate and robust determination of the time between the presentation of a visual stimulus and the beginning of the eye movement toward the stimulus (saccade latency). Additionally, we proposed a model-based method to determine the onset of the eye movement and demonstrate that the associated residual normalized root-mean-squared error can be used to automatically flag saccade tracings that should not be included in further analysis. A variant of the iTracker algorithm performs most robustly and results in mean saccade latencies and associated standard deviations on iPhone recordings that are essentially the same as those obtained from simultaneous recordings using a high-end, high-speed camera. Our results suggest that accurate and robust saccade latency determination is feasible using consumer-grade cameras and therefore might enable unobtrusive tracking of neurodegenerative disease progression.
关键词： Eye tracking,saccade latency,mobile imaging,health monitoring,convolutional neural networks
更新于2025-09-04 15:30:14
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Evaluation of renal oxygen saturation using photoacoustic imaging for the early prediction of chronic renal function in a model of ischemia-induced acute kidney injury
摘要： To evaluate the utility of photoacoustic imaging in measuring changes in renal oxygen saturation after ischemia-induced acute kidney injury, and to compare these measurements with histological findings and serum levels of kidney function.
关键词： chronic renal function,ischemia-reperfusion,renal oxygen saturation,acute kidney injury,photoacoustic imaging
更新于2025-09-04 15:30:14
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Near-infrared nanoparticles based on indocyanine green-conjugated albumin: a versatile platform for imaging-guided synergistic tumor chemo-phototherapy with temperature-responsive drug release
摘要： The aim of this study was to develop a multifunctional theranostic agent based on BSA nanoparticles (NPs), which loaded artemisinin (ART) and co-conjugated with indocyanine green (ICG) and arginine-glycine-aspartic acid (RGD) peptide (RGD-indocyanine green-Bovine Serum Albumin- artemisinin [IBA] NPs). The physicochemical parameters of RGD-IBA NPs were characterized in terms of the particle size, zeta potential, morphology, entrapment efficiency, drug loading, in vitro release behavior, photothermal and photodynamic effect, and in vitro anticancer ability. In vivo fluorescence and thermal imaging as well as antitumor studies were also evaluated. The tumor chemotherapeutic effects of ART and the ability of fluorescence imaging, hyperthermia generation and reactive oxygen species production of ICG and tumor-targeting RGD were integrated to achieve RGD-IBA NPs for imaging-guided tumor-targeted chemotherapy/photothermal/photodynamic therapy (chemo-phototherapy). The RGD-IBA NPs showed enhanced physiological stability and photo-stability compared with free ART and ICG. In addition, they were temperature-responsive; their sizes increased with increasing temperature between 25°C and 55°C, thereby leading to drug release upon the irradiation with near infrared (NIR) laser. In vivo fluorescence images of tumor-bearing mice showed that the RGD-IBA NPs could highly and passively reach the targeted tumor region with maximum accumulation at 24 hours post-intravenous injection. The in vitro and in vivo results demonstrated that the RGD-IBA NPs not only have good biocompatibility, but also are highly efficient tumor synergistic chemo-phototherapeutic agents. Through this study, it was found that RGD-IBA NPs could potentially be a very promising tumor theranostic agent.
关键词： chemo-phototherapy,indocyanine green,imaging-guided tumor therapy,artemisinin,theranostic
更新于2025-09-04 15:30:14