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- 2017
- spectral reconstruction
- interference
- polarization
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- imaging spectrometer
- Optoelectronic Information Science and Engineering
- BITTT
- Zhejiang University
- Guilin University of Aerospace Technology
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Ensayo Pictórico: Control imagenológico de aneurismas tratados ?Qué examen elegir?
摘要： Treatment of intracranial ruptured and unruptured aneurysms can be performed with surgical (vascular clips) or endovascular procedures (coils, stents, flow diverters). There are several devices and techniques for endovascular treatment. Knowledge of this techniques allows physicians to choose and interpret accurately imaging modalities for non-invasive follow-up. Through a pictorial essay of imaging follow-up of treated intracranial aneurysms we show the differences in characterization with computed tomography angiography, magnetic resonance angiography without contrast (time of flight or “TOF” technique), contrast enhanced MR angiography (C+) and digital subtraction angiography (DSA). Additionally we recommend imaging modalities for each treatment device.
关键词： brain aneurysms,flow diverter,vascular clips,intracranial stent,imaging follow-up,coils
更新于2025-09-04 15:30:14
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Intraoperative OCT imaging of the Argus II retinal prosthesis and its clinical significance
摘要： To report the clinical, multimodal imaging and genetic characteristics of patients with Enhanced-S-cone syndrome (ESCS) in a Tunisian cohort. Methods: Descriptive clinical and genetic study including patients with inherited retinal dystrophies who consulted the oculogenetics laboratory LR14SP01, at Hedi Rais Institute of ophthalmology. Results: A total of 9 patients from 6 consanguineous families were diagnosed with ESCS based on typical clinical and ERG abnormalities. All patients complaint from hemeralopia since childhood. Visual acuity ranged from light perception to 4/10. Fundus examination revealed variable abnormalities with radial yellow dots in the posterior pole in two patients, nummular yellow dots in one patient, minimal pigmentary changes along the arcades in five patients, nummular pigment clumping in 3 patients and peripheral retinal atrophy in one patient. One patient had macular atrophy and 8 had macular cysts confirmed by SS-OCT. Genetic analysis was contributive in 7 patients and revealed NR2E3 mutations in 5 patients and NR2E3 + RHO digenism in two patients from the same family. Conclusions: This is to our knowledge the first report on a Tunisian cohort with ESCS. The phenotype in ESCS is highly variable and multimodal imaging may help to the diagnosis in addition to electrophysiology results.
关键词： genetic characteristics,ESCS,multimodal imaging,Enhanced-S-cone syndrome,Tunisian cohort
更新于2025-09-04 15:30:14
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Comparison of MultiColor fundus imaging and colour fundus photography in the evaluation of epiretinal membrane
摘要： Purpose: To compare MultiColor fundus imaging (MC) and colour fundus photography (CFP) for the evaluation of epiretinal membrane (ERM). Methods: In this retrospective study, 192 eyes (181 patients) that underwent vitrectomy for ERM were imaged using Spectralis optical coherence tomography (for MC) and AFC-210 digital camera (for CFP) 1 week before vitrectomy. Two investigators independently determined the rate of delineability and ERM area for each modality. Results: The intergrader agreement rates for delineability were very high for both image modalities. The rate of delineability of ERM (%) was higher for MC than for CFP, for both investigators [70.8% versus 52.6% and 73.4% versus 53.6% (both p –)]. Epiretinal membrane (ERM) area measurement showed high agreement between investigators for MC (p = 0.466) but di?ered signi?cantly between the investigators for CFP (p –). The ERM area determined on MC was signi?cantly wider than that on CFP for both investigators (p – for investigator 1 and p – for investigator 2). Conclusion: The ERM area is more clearly detectable and widely demarcated in MC than in CFP images. MultiColor imaging (MC) may be more sensitive and accurate for early detection of ERM and ERM area measurement.
关键词： MultiColor imaging,spectral-domain optical coherent tomography,epiretinal membrane,colour fundus photography
更新于2025-09-04 15:30:14
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Surgical management of proximal coronary arteriovenous fistulas using intraoperative fluorescence imaging
摘要： We report the use of intraoperative fluorescence imaging to assist in the surgical management of proximal coronary arteriovenous fistulas in four patients.
关键词： coronary arteriovenous fistula,fluorescence imaging,surgical technique
更新于2025-09-04 15:30:14
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Acute subretinal abscess in <i>Staphylococcus aureus</i> septicaemia with endophthalmitis showcased by multimodal retinal imaging and with 2-year follow-up
摘要： A middle-aged man presented to emergency services with central vision loss in the setting of flu-like illness with fever. A striking subfoveal abscess was observed in the right fundus. Focal acute chorioretinal inflammation was noted in the asymptomatic fellow eye. Staphylococcus aureus septicaemia was subsequently diagnosed. He presented with undiagnosed HIV infection and latent syphilis. Serial high-definition multimodal retinal imaging showcased resolution of the dome-shaped subretinal abscess following treatment with intravenous flucloxacillin. A chorioretinal scar swiftly replaced the subfoveal abscess. Peripheral right vision and full left vision was retained. Vision loss due to endogenous endophthalmitis in systemic sepsis is an emergency requiring prompt multidisciplinary care. Sight and life are at risk—thus this is not a diagnosis to miss! Early recognition is paramount to health and in retaining vision. We briefly review relevant literature and portray how multimodal imaging guided response to treatment of acute subretinal abscess.
关键词： endophthalmitis,Staphylococcus aureus septicaemia,multimodal retinal imaging,HIV infection,acute subretinal abscess,latent syphilis
更新于2025-09-04 15:30:14
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Corneal Fibroblast Migration Patterns During Intrastromal Wound Healing Correlate With ECM Structure and Alignment
摘要： PURPOSE. To assess keratocyte backscattering, alignment, morphology, and connectivity in vivo following a full-thickness corneal injury using the Heidelberg Retina Tomograph Rostock Cornea Module (HRT-RCM), and to correlate these findings with en bloc three-dimensional (3-D) confocal fluorescence and second harmonic generation (SHG) imaging. METHODS. Rabbit corneas were scanned in vivo both before and 3, 7, 14, and 28 days after transcorneal freeze injury (FI), which damages all corneal cell layers. Corneal tissue was also fixed and labeled for f-actin and nuclei en bloc, and imaged using 3-D confocal fluorescence microscopy and SHG imaging. RESULTS. Using the modified HRT-RCM, full-thickness scans of all cell layers were consistently obtained. Following FI, stromal cells repopulating the damaged tissue assumed an elongated fibroblastic morphology, and a significant increase in cellular light scattering was measured. This stromal haze gradually decreased as wound healing progressed. Parallel, interconnected streams of aligned corneal fibroblasts were observed both in vivo (from HRT-RCM reflection images) and ex vivo (from f-actin and nuclear labeling) during wound healing, particularly in the posterior cornea. Second harmonic generation imaging demonstrated that these cells were aligned parallel to the collagen lamellae. CONCLUSIONS. The modified HRT-RCM allows in vivo measurements of sublayer thickness, assessment of cell morphology, alignment and connectivity, and estimation of stromal backscatter during wound healing. In this study, these in vivo observations led to the novel finding that the pattern of corneal fibroblast alignment is highly correlated with lamellar organization, suggesting contact guidance of intrastromal migration that may facilitate more rapid wound repopulation.
关键词： SHG imaging,confocal microscopy,corneal wound healing,extracellular matrix
更新于2025-09-04 15:30:14
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Effect of Uveal Melanocytes on Choroidal Morphology in Rhesus Macaques and Humans on Enhanced-Depth Imaging Optical Coherence Tomography
摘要： PURPOSE. To compare cross-sectional choroidal morphology in rhesus macaque and human eyes using enhanced-depth imaging optical coherence tomography (EDI-OCT) and histologic analysis. METHODS. Enhanced-depth imaging–OCT images from 25 rhesus macaque and 30 human eyes were evaluated for choriocapillaris and choroidal–scleral junction (CSJ) visibility in the central macula based on OCT re?ectivity pro?les, and compared with age-matched histologic sections. Semiautomated segmentation of the choriocapillaris and CSJ was used to measure choriocapillary and choroidal thickness, respectively. Multivariate regression was performed to determine the association of age, refractive error, and race with choriocapillaris and CSJ visibility. RESULTS. Rhesus macaques exhibit a distinct hypore?ective choriocapillaris layer on EDI-OCT, while the CSJ cannot be visualized. In contrast, humans show variable re?ectivities of the choriocapillaris, with a distinct CSJ seen in many subjects. Histologic sections demonstrate large, darkly pigmented melanocytes that are densely distributed in the macaque choroid, while melanocytes in humans are smaller, less pigmented, and variably distributed. Optical coherence tomography re?ectivity patterns of the choroid appear to correspond to the density, size, and pigmentation of choroidal melanocytes. Mean choriocapillary thickness was similar between the two species (19.3 6 3.4 vs. 19.8 6 3.4 lm, P ? 0.615), but choroidal thickness may be lower in macaques than in humans (191.2 6 43.0 vs. 266.8 6 78.0 lm, P < 0.001). Racial differences in uveal pigmentation also appear to affect the visibility of the choriocapillaris and CSJ on EDI-OCT. CONCLUSIONS. Pigmented uveal melanocytes affect choroidal morphology on EDI-OCT in rhesus macaque and human eyes. Racial differences in pigmentation may affect choriocapillaris and CSJ visibility, and may in?uence the accuracy of choroidal thickness measurements.
关键词： choroid,OCT,rhesus macaques,imaging,melanocytes
更新于2025-09-04 15:30:14
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[American Society of Agricultural and Biological Engineers 2017 Spokane, Washington July 16 - July 19, 2017 - ()] 2017 Spokane, Washington July 16 - July 19, 2017 - <i>Variety classification of maize kernels using near infrared (NIR) hyperspectral imaging</i>
摘要： Variety classification of maize kernels was evaluated using near infrared (NIR) hyperspectral imaging in this work. Firstly, NIR hyperspectral images of kernels of four widely used maize varieties were acquired within effective spectral range of 1000-2500 nm. Spectral math was used to compensate for minor lighting differences, and band math combined with threshold method was used to remove the background from images. Minimum noise fraction (MNF) was adopted to reduce noise. Texture features (mean, variance, homogeneity, contrast, dissimilarity, entropy, second moment, and correlation) as appearance character of each maize kernel were calculated and extracted to establish classification model combined with spectra data. Moving average smoothing and standard normal variate were applied on the raw spectra extracted from hyperspectral images. Four optimal wavelengths (1352.20 nm, 1615.50 nm, 1733.10 nm, and 2478.20 nm) were selected by competitive adaptive reweighted sampling (CARS) method. Partial least squares discriminant analysis (PLSDA) was employed to build varieties classification models, based on full wavelength data, the four wavelengths data, and combination of spectral and textural features at four wavelengths, respectively. Results demonstrated that PLSDA model based on combination of spectral and textural features had the best performance with accuracies of 0.89, 0.83 for calibration and prediction set, which indicated the hyperspectral imaging technique with combination of spectral and textural features had a potential of application for variety classification.
关键词： Variety classification,Maize kernel,NIR hyperspectral imaging,Partial least squares discriminant analysis (PLSDA),Competitive adaptive reweighted sampling (CARS) method
更新于2025-09-04 15:30:14
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Multimodal imaging and diagnosis of myopic choroidal neovascularization in Caucasians
摘要： Purpose: To investigate myopic choroidal neovascularization (mCNV) by fluorescein angiography (FA), spectral-domain optical coherence tomography (SD-OCT), near-infrared (NIR) reflectance, and autofluorescence (AF). Methods: This retrospective study included 65 eyes of 62 Caucasian patients with a mean age of 66.72 years (95% confidence interval [CI] 63–70 years) and a mean refraction of -9.72 diopters (95% CI -8.74 to -10.70 diopters). Results: Most of the mCNV cases were foveal-juxtafoveal (60/65, 92.3%), with thickening of the corresponding retina (62/65, 95.3%) and leakage on FA (44/65, 67.6%). No retinal fluid was detectable in 32 (49.2%) eyes and there was no hemorrhage in 25 (38.4%) eyes. Papillary chorioretinal atrophy was evident in 58 (89.2%), a shadowing effect in 48 (73.8%), and an epiretinal membrane in 38 (58.4%) eyes. If an area of macular chorioretinal atrophy was present, mCNV frequently developed adjacent to it and was hyperfluorescent rather than with leakage (P<0.001). In eyes with edema or hemorrhage, hyper-reflective foci were more frequent (P<0.005). NIR and AF features were indeterminable in 19 (29.2%) and 27 (41.5%) eyes, respectively. The predominant feature was black or grayish on NIR (34/65, 52.3%) and patchy (hypo- and hyperfluorescence was observed) on AF (25/65, 38.4%). FA and SD-OCT correctly detected mCNV in 49 (75.3%) and 48 (73.8%) eyes, respectively, whereas NIR and AF exhibited limited diagnostic sensitivity. Doubtful diagnosis was associated with hyperfluorescent mCNV (P<0.001), absence of retinal fluid and epiretinal membrane (P<0.05), and presence of macular chorioretinal atrophy (P<0.01). Conclusion: Tomographic, angiographic, AF, and NIR features of mCNV are described in this study. Combination of SD-OCT and FA is recommendable for diagnosis.
关键词： fluorescein angiography,pathologic myopia,myopic neovascularization,SD-OCT,CNV,imaging
更新于2025-09-04 15:30:14
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The challenges and opportunities in functional imaging HER2 positive breast cancers
摘要： Breast cancer is the most common malignancy in women and 20‐30% of these cancers overexpress the HER2 protein making them candidates for HER2‐directed therapies. Trastuzumab (Herceptin?), the first HER2‐directed therapy, is a humanized monoclonal antibody that binds to the extracellular domain of HER2 preventing downstream signaling and cell proliferation. Trastuzumab is also an immunologic agent stimulating antibody‐dependent cytotoxicity. Investigators have developed radiolabeled trastuzumab as a PET imaging agent for use in HER2‐positive breast cancer patients. However, its clinical role has yet to be established. In the Journal, Dr. Woo and his colleagues report the use of NOTA as a chelator for 64Cu labeling of trastuzumab and claim more favorable pharmacokinetics than 64Cu DOTA trastuzumab [1]. But is NOTA a better chelator for 64Cu than DOTA? They base their comparison on a report by Paudyal et al. (Cancer Sci 2010; 101: 1045‐1050) in which the uptake of 64Cu‐DOTA‐trastuzumab in the liver was 26.9 ±7.4% ID/g at 24 hours[12], while in contrast, the uptake of 64Cu‐NOTA‐trastuzumab was 5.44 ±1.84%D/g in the liver at 24 hours (Figure 4)[1]. They conclude the difference in liver uptake between the two studies was due to release of 64Cu from the DOTA but not from the NOTA chelate. However, the two studies cannot be compared since they were not performed using the same tumor models. Paudyal et al. (Cancer Sci 2010; 101: 1045‐1050) performed PET imaging on Her2+ non‐small cell xenografts, while Woo et al. performed PET imaging on Her2+ breast cancer xenografts. The difference in liver uptake may simply reflect differential shedding of Her2 antigen to the liver between the two types of tumors. To make their point, Woo et al. should have compared DOTA vs NOTA conjugated trastuzumab in the same tumor model. This is a clear example of confusing the chemical stability of metal chelates with their metabolic clearance in different tumor models.
关键词： PET imaging,breast cancer,HER2,DOTA,trastuzumab,NOTA
更新于2025-09-04 15:30:14