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Ocular Aberrations and Corneal Thickness-Intraocular Pressure Relationship One Year after Laser in situ Keratomileusis (LASIK) Enhancement with An Aspheric Ablation Profile
摘要： Objective: To evaluate the effect of an aspheric LASIK refractive enhancement performed by relifting the original flap on the higher order aberrations (HOA) of the eye and the relationship between central corneal thickness (CCT) and intra-ocular pressure (IOP). Methods: Consecutive case series of 30 eyes requiring refractive enhancement from 1804 uncomplicated primary LASIK procedures performed in 2012. Flap relift and wavefront optimized ablation (Wavelight Allegretto Eye Q 400 Hz excimer laser) were performed in all cases. Pre-and post-operative examination included Shack-Hartmann aberrometry for 3 mm and 5 mm pupil sizes, CCT and IOP. Postoperative results at 1 year were compared to baseline values. Results: Changes in average values of coma, spherical aberration (SA), trefoil, CCT and IOP were not significant. Linear regression revealed significant associations between change (y) in trefoil and pre-enhancement value of trefoil for 3 mm pupil (0.828x-0.045, r=0.722, p<0.001), coma and pre-enhancement value of coma for 5 mm pupil (y=0.281x-0.030, r=0.501, n=30, p=0.048), SA for 3 mm pupil compared with change in CT (y=0.0080-0.0009x, r=-0.378, p=0.0392), and SA for 5 mm pupil compared with change in CCT (y=0.0035x-0.0541, r=0.524, p=0.0029). Also there was a significant association between IOP and CCT both pre-(IOP=0.0313CT-3.3, r=0.740, p<0.0001) and post-enhancement (IOP=0.0243CT-0.018, r=0.675, p<0.0001). Conclusion: LASIK enhancement with an aspheric ablation profile did not significantly impact on the average values for HOAs, IOP or CCT. For individual cases, the likely shift in magnitude of coma, trefoil and SA can be estimated and, the change in SA is correlated with changes in CCT. The change in the abscissa value linking IOP with CCT may be an indication of changes in biomechanical properties of the cornea in the central region.
关键词： High order aberrations (Hoas),LASIK enhancement,Wavefront,Intraocular pressure (IOP),Excimer laser,Wavelight allegretto,Corneal thickness
更新于2025-09-16 10:30:52
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Two-Dimensional Plasmonic Grating for Intraocular Pressure Sensing
摘要： Glaucoma is a group of characteristic optic neuropathies that collectively are the leading cause of irreversible blindness globally. Elevated intraocular pressure (IOP) is the major causal risk factor. While the fundamental mechanisms of the IOP elevation and consequent optic neuropathy are not well understood, recent studies have indicated that there may be pressure spikes directed at the optic nerve head during accommodation and that IOP may not be homogeneous throughout the eye. To facilitate the in situ and in vivo measurement of IOP in various locations within the vitreous and facilitate measurement of accommodative IOP spikes at the ONH, here, we report the development of an implantable, biocompatible, and miniaturized IOP sensor using 2-D plasmonic grating that generates structural color. The change of the grating period with pressure between 0 and 50 mmHg results in a change in the visible color, allowing us to observe small changes in pressure without additional electronics.
关键词： glaucoma,intraocular pressure (IOP),Electromagnetic wave sensors,optical nerve head (ONH),surface plasmon
更新于2025-09-11 14:15:04