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Anatomical Characterization of an Optic Disc Notch Using SD-OCT in Glaucoma
摘要： Purpose: To characterize anatomical dimensions of a disc notch using novel methods using spectral domain optical coherence tomography (SD-OCT). Participants: All age- and severity-matched glaucoma patients with disc notch (defined as complete loss of neural rim with no residual rim between disc and cup) seen from 2014 to 2015 who underwent enhanced depth imaging with SD-OCT (Cirrus HD-OCT version 6.5, Carl Zeiss, USA) were included for this retrospective observational study. Methods: Using known dimensions of the 200 * 200 optic disc cube (6 * 6 mm), the notch width was calculated from the margins of the notch on either side using ImageJ software. The height was calculated from the lowest margin of the cup to the lowest point of the defect on the optic disc. These were compared with the quadrant retinal nerve fiber layer (qRNFT) and sectoral retinal nerve fiber layer (sRNFLT) thickness in notch and the sector 2 clock hours adjacent to the notch region (SaRNFLT). Results: The height and width of the notch in 31 eyes of 27 patients were 2.6 ± 0.48 mm and 2.23 ± 0.31 mm. The RNFL thickness in the same sector as that of the notch was 41 ± 21.06 μm while the adjacent two sectors measured 62 ± 26.5 and 64 ± 26.5 μm on either sides of the sector of the notch. The difference between the sRNFLT and saRNFLT ranged from ?9 to 67 and ?13 to 50 μm, respectively. This difference was significantly associated with height of the notch (R2 = 20.8, p = 0.01). Conclusion: Automated analysis of a notch and RNFL thickness in that sector can help in precise glaucoma monitoring in the region of interest.
关键词： glaucoma,optic disc pit,Optical coherence tomography,lamina cribrosa,optic disc notch
更新于2025-09-23 15:21:01
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Relationship between the Lamina Cribrosa, Outer Retina, and Choroidal Thickness as Assessed Using Spectral Domain Optical Coherence Tomography
摘要： To evaluate the characteristics and relationship between peripapillary choroidal thickness (pCT), lamina cribrosa thickness (LCT), and peripapillary outer retinal layer thickness (pORT) as determined using spectral domain optical coherence tomography (SD-OCT) enhanced depth imaging (EDI).
关键词： Outer retinal thickness,Lamina cribrosa thickness,Optical coherence tomography,Choroidal thickness,Glaucoma
更新于2025-09-23 15:21:01
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Pilot study for three-dimensional assessment of laminar pore structure in patients with glaucoma, as measured with swept source optical coherence tomography
摘要： Purpose To develop a method to quantify, based on swept-source optical coherence tomography (OCT), the 3D structure of the laminar pores in patients with glaucoma. Methods This retrospective study examined 160 laminar pores from 8 eyes of 8 cases: 4 normal subjects and 4 open-angle glaucoma (OAG) patients. We reconstructed 3D volume data for a 3 x 3 mm disc, using a method similar to OCT angiography, and segmented the structure of the lamina cribrosa. Then, we manually segmented each laminar pore in sequential C-scan images (>90 slices at 2.6-micron intervals) with VCAT5 (RIKEN, Japan). We compared the control and OAG subjects with the Mann-Whitney U test. Differences were considered significant at p < 0.05. Results We found that the laminar pores of the OAG patients had a significantly smaller average cross-sectional area, smaller 3D volume (adjusted to the average thickness of the lamina cribrosa), and higher true sphericity, and lower principal value (P1, 2, 3) of the 3D structure data (all: p < 0.0001). The topographic distribution of damaged laminar pores was consistent with the damaged area of the macular map. Conclusion We successfully developed a method to quantify the 3D structure of the laminar pores; providing a useful tool to assess lamina cribrosa-associated risk factors for glaucoma. These findings promise to benefit future investigations into the pathomechanisms of glaucoma.
关键词： swept-source optical coherence tomography,glaucoma,lamina cribrosa,laminar pores,3D structure
更新于2025-09-10 09:29:36
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Parameters of ocular fundus on spectral-domain optical coherence tomography for glaucoma diagnosis
摘要： In this review, we summarize the progression of several parameters assessed by spectral-domain optical coherence tomography (SD-OCT) in recent years for the detection of glaucoma. Monitoring the progression of defects in the retinal nerve fiber layer (RNFL) thickness is essential. Imaging and analysis of retinal ganglion cells (RGCs) and inner plexiform layer (IPL), respectively, have been of great importance. Optic nerve head (ONH) topography obtained from 3D SD-OCT images is another crucial step. Other important assessments involve locating the Bruch’s membrane opening (BMO), estimating the optic disc size and rim area, and measuring the lamina cribrosa displacement. Still other parameters found in the past three years for glaucoma diagnosis comprise central retinal artery resistive index, optic disc perfusion in optical coherence tomography angiography (OCTA) study, peripapillary choroidal thickness, and choroidal area in SD-OCT. Recently, several more ocular fundus parameters have been found, and compared with the earlier parameters to judge the accuracy of diagnosis. While a few of these parameters have been widely used in clinical practice, a fair number are still in the experimental stage.
关键词： optic nerve head,retinal nerve fiber layer,lamina cribrosa,optical coherence tomography,macular thickness,ganglion cells,glaucoma progression
更新于2025-09-09 09:28:46
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Variation in the Three-Dimensional Histomorphometry of the Normal Human Optic Nerve Head With Age and Race: Lamina Cribrosa and Peripapillary Scleral Thickness and Position
摘要： This study quantified the thickness and depth of the lamina cribrosa (LC) and peripapillary scleral thickness in high-resolution three-dimensional (3D) fluorescent reconstructions of the optic nerve head (ONH) in eyes from donors of African (AD) and European descent (ED). A total of 64 eyes (45 ED, 19 AD) from 51 normal donors were obtained within 6 hours of death and fixed at 10 mm Hg of pressure. The optic nerve head was trephined from the globe and digitally reconstructed at 1.5 3 1.5 3 1.5 lm voxel resolution with an automated episcopic fluorescence technique. The load-bearing ONH connective tissue surfaces were manually delineated in 3D using custom software. The lamina cribrosa and peripapillary sclera were significantly thinner in AD eyes adjusting for age and sex (LC was 24 6 11 lm thinner; P ? 0.0350; scleral was 56 6 22 lm thinner; P ? 0.0097). The lamina cribrosa was significantly thinner in females (23 6 11 lm thinner; P ? 0.0425). Age was not significantly associated with any morphologic parameter in the ED group. However, increasing age was associated with an increase in scleral thickness (1.3 lm/year, P ? 0.0499) and an increase in LC depth (2.3 lm/year, P ? 0.0035) in the AD group. The sclera was thickest in the superior and temporal regions while the LC was thinnest superiorly. Substantial sectorial and racial differences in LC and scleral morphology were observed, as well as increasing LC depth and scleral thickness with age in the AD group. Results suggest greater age-related remodeling of the load-bearing ONH connective tissues in eyes from AD individuals that could explain, in part, the greater predilection to glaucomatous injury seen in aged AD populations.
关键词： race,lamina cribrosa,morphometry,optic nerve head
更新于2025-09-09 09:28:46
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Shape Changes of the Anterior Lamina Cribrosa in Normal, Ocular Hypertensive, and Glaucomatous Eyes Following Acute Intraocular Pressure Elevation
摘要： PURPOSE. The purpose of this study was to estimate and compare changes in anterior lamina cribrosa (LC) morphology in normal, ocular hypertensive (OHT), and glaucomatous eyes following acute elevations in intraocular pressure (IOP). METHODS. The optic nerve heads (ONHs) of 97 subjects (17 OHT, 19 primary open-angle glaucoma [POAG], 31 primary angle-closure glaucoma [PACG], and 30 normal subjects) were imaged using optical coherence tomography (OCT). Intraocular pressure was raised twice by applying forces to the anterior sclera, using an ophthalmodynamometer. After each IOP elevation, IOP was held constant and measured; each ONH was rescanned with OCT. In each OCT volume, the anterior LC was enhanced, delineated, and its global shape index (GSI) calculated and compared across groups. RESULTS. The baseline IOP was 17.5 6 3.5 mm Hg and was increased to 38 6 5.9 mm Hg and then to 46.5 6 5.9 mm Hg. At the ?rst IOP increment, mean GSI was signi?cantly smaller than that at baseline in normal subjects and glaucoma subjects (P < 0.05) but not in OHT subjects (P ? 0.12). For the second IOP increment, the mean GSI was signi?cantly smaller than that at baseline in normal subjects and in OHT eyes (P < 0.05). After adjusting for age, sex, and baseline IOP, the LC of POAG eyes was found to be signi?cantly more posteriorly curved than that of normal subjects (P ? 0.04). CONCLUSIONS. Acute IOP elevations altered anterior LC shape in a complex nonlinear fashion. The LC of POAG eyes was more cupped following acute IOP elevations compared to that of normal subjects.
关键词： morphometry,glaucoma,elevation,global shape index,intraocular pressure,lamina cribrosa,adaptive compensation
更新于2025-09-04 15:30:14