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Quantitative imaging techniques for the assessment of osteoporosis and sarcopenia
摘要： Bone and muscle are two deeply interconnected organs and a strong relationship between them exists in their development and maintenance. The peak of both bone and muscle mass is achieved in early adulthood, followed by a progressive decline after the age of 40. The increase in life expectancy in developed countries resulted in an increase of degenerative diseases affecting the musculoskeletal system. Osteoporosis and sarcopenia represent a major cause of morbidity and mortality in the elderly population and are associated with a significant increase in healthcare costs. Several imaging techniques are currently available for the non-invasive investigation of bone and muscle mass and quality. Conventional radiology, dual energy X-ray absorptiometry (DXA), computed tomography (CT), magnetic resonance imaging (MRI) and ultrasound often play a complementary role in the study of osteoporosis and sarcopenia, depicting different aspects of the same pathology. This paper presents the different imaging modalities currently used for the investigation of bone and muscle mass and quality in osteoporosis and sarcopenia with special emphasis on the clinical applications and limitations of each technique and with the intent to provide interesting insights into recent advances in the field of conventional imaging, novel high-resolution techniques and fracture risk.
关键词： sarcopenia,Osteoporosis,photon,magnetic resonance imaging (MRI),absorptiometry,multidetector computed tomography (CT)
更新于2025-09-23 15:21:01
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Imaging as a Personalized Biomarker for Prostate Cancer Risk Stratification
摘要： Biomarkers provide objective data to guide clinicians in disease management. Prostate-specific antigen serves as a biomarker for screening of prostate cancer but has come under scrutiny for detection of clinically indolent disease. Multiple imaging techniques demonstrate promising results for diagnosing, staging, and determining definitive management of prostate cancer. One such modality, multiparametric magnetic resonance imaging (mpMRI), detects more clinically significant disease while missing lower volume and clinically insignificant disease. It also provides valuable information regarding tumor characteristics such as location and extraprostatic extension to guide surgical planning. Information from mpMRI may also help patients avoid unnecessary biopsies in the future. It can also be incorporated into targeted biopsies as well as following patients on active surveillance. Other novel techniques have also been developed to detect metastatic disease with advantages over traditional computer tomography and magnetic resonance imaging, which primarily rely on defined size criteria. These new techniques take advantage of underlying biological changes in prostate cancer tissue to identify metastatic disease. The purpose of this review is to present literature on imaging as a personalized biomarker for prostate cancer risk stratification.
关键词： magnetic resonance imaging (MRI),cancer staging,active surveillance,radical prostatectomy,Gleason score,radiation therapy
更新于2025-09-09 09:28:46
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Hilbert Curve-Based Metasurface to Enhance Sensitivity of Radio Frequency Coils for 7-T MRI
摘要： In this paper, we propose a compact, lightweight, and easy-to-fabricate Hilbert curve-based metasurface resonator that can effectively increase the sensitivity (radio frequency (RF) field intensity) and penetration depth of an RF coil for 7-T magnetic resonance imaging scanner. A circuit model is proposed to accurately calculate the resonance frequency of Hilbert curve resonators of different orders. A single element of a transverse electromagnetic (EM) coil was used for this paper. The increase in the field sensitivity introduced by the proposed metasurface to an RF coil was successfully demonstrated through simulations and experiments. The EM field produced by the RF coil is redistributed due to the presence of the proposed metasurface. The key feature of the proposed structure is its significant increase in the penetration depth of magnetic fields into the imaging volume. An enhancement of the magnetic field by more than four times was observed at 13.5 cm away from the coil experimentally. Flexibility for matching the coil integrated with the proposed surface is shown.
关键词： metasurface,magnetic resonance imaging (MRI),radio frequency (RF) coil,Hilbert curve
更新于2025-09-04 15:30:14