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Evaluation of blood flow on optic nerve head after pattern scan and conventional laser panretinal photocoagulation
摘要： To evaluate the changes in the blood ?ow on retina and the optic nerve head (ONH) after conventional laser treatment and to compare it to that after patterned scanning laser (PASCAL) treatment in patients with severe nonproliferative diabetic retinopathy (S-NPDR). In this prospective, cross-sectional study, the blood ?ow on retina and the ONH was assessed by laser speckle ?owgraphy using the mean blur rate (MBR) in 39 eyes with S-NPDR before, 1, 4, 8, 12 weeks after panretinal photocoagulation (PRP). Of 39 eyes, 17eyes with 17 patients treated by conventional laser and 22 eyes with 22 patients treated by PASCAL. The mean age was 55.5 ± 11.5 years in the conventional laser group, 55.6 ± 11.8 years in the PASCAL group. The MBR-vessel, which can be dominantly expressed as retinal blood ?ow, was signi?cantly reduced after PRP treated by conventional laser (P < .001), but did not change after PRP treated by PASCAL. The ratio of MBR-vessel to the baseline was signi?cantly lower in the conventional laser group only at Week 1 (P = .045). The MBR-tissue, which can be dominantly expressed as the ONH blood ?ow, did not signi?cantly change after PRP in the both group. The multiple stepwise regression analysis revealed that the laser burns was an independent factor signi?cantly correlated with the ratio of MBR-vessel at Week 1 to the baseline (b = (cid:1)0.550, P = .012). The retinal blood ?ow was signi?cantly reduced during the 12 weeks only after completion of PRP by conventional laser treatment. Our results indicate that short pulse on PRP treatment performed by the PASCAL would not signi?cantly reduce the retinal blood ?ow.
关键词： laser speckle ?owgraphy,patterned scanning laser,panretinal photocoagulation,mean blur rate,retinal blood ?ow
更新于2025-09-12 10:27:22
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Pulse Waveform Changes in Macular Choroidal Hemodynamics With Regression of Acute Central Serous Chorioretinopathy
摘要： PURPOSE. To quantitatively evaluate the pulse waveform changes in macular choroidal blood ?ow by using laser speckle ?owgraphy (LSFG) with regression of acute central serous chorioretinopathy (CSC). METHODS. This retrospective observational case series included 20 eyes of 20 patients with acute CSC. Laser speckle ?owgraphy was performed at baseline and after 6 months. On the LSFG monochrome map, automatically divided 5 3 5 grid segments within the macula were classi?ed into predominantly delayed ?lling (PDF) or minimally or no delayed ?lling (MDF) areas according to the degree of choroidal ?lling delay on early-phase indocyanine green angiography. The average mean blur rate (MBR) and the pulse waveform parameters, including the skew and blowout time (BOT), were compared between the total PDF and MDF areas during follow-up. RESULTS. The average MBR signi?cantly decreased in both PDF (P ? 0.005) and MDF (P < 0.001) areas during follow-up; in both areas, the skew decreased (P < 0.001 and P ? 0.006, respectively) and BOT increased (P < 0.001 for each), showing signi?cant reduction in vascular resistance at 6 months. The degree of the changes in the skew and BOT was signi?cantly larger (P ? 0.02 and P < 0.001, respectively) in the PDF area than in the MDF area. CONCLUSIONS. Changes in the skew and BOT, indices for vascular resistance, con?rmed the involvement of circulatory disturbance at the acute stage of CSC. The present ?ndings suggested that the pathogenesis of CSC stems from imbalanced distribution of choroidal blood ?ow due to augmented vascular resistance.
关键词： central serous chorioretinopathy,pulse waveform,skew,blowout time,mean blur rate,laser speckle ?owgraphy,choroidal blood ?ow velocity
更新于2025-09-04 15:30:14