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Multifunctional nanoplatforms for photoacoustic imaging-guided combined therapy enhanced by CO induced ferroptosis
摘要： A multifunctional CO/thermo/chemotherapy nanoplatform is here reported, which is composed of mesoporous carbon nanoparticles (MCN) as near-infrared (NIR)-responsive drug carrier, doxorubicin (DOX) as chemotherapeutic drug and triiron dodecacarbonyl (FeCO) as thermosensitive CO prodrug. The nanoplatform could absorb near-infrared (NIR) light and convert it into ample heat to trigger CO release and could also release DOX in the acidic tumor microenvironment. More importantly, the generated CO molecules successfully increase cancer cell sensitivity to chemotherapeutics by the ferroptosis pathway. Subsequently, under the guidance of photoacoustic imaging, the FeCO-DOX@MCN nanoplatform demonstrates high treatment efficacies in vitro and in vivo by combination of chemotherapy, photothermal therapy and gas therapy. This multifunctional platform with excellent antitumor efficacy has great potential in precision cancer therapy.
关键词： Mesoporous materials,Ferroptosis,Controlled release,Photothermal therapy,Carbon monoxide
更新于2025-09-23 15:22:29
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Preparation of ordered mesoporous Au using double gyroid mesoporous silica KIT-6 via a seed-mediated growth process
摘要： Ordered mesoporous Au was prepared using double-gyroid (cubic Ia3d) mesoporous silica KIT-6 as a template. The Au frameworks were formed within the template via a seed-mediated growth process. Au nanoparticles were initially prepared as seeds within the mesopores, and subsequently, they were grown under mild and controlled reducing conditions. The transmission electron micrographs and scanning electron micrographs of mesoporous Au after the removal of the template revealed the formation of mesoporous Au replicas. The small-angle X-ray scattering pattern of mesoporous Au reveals that the obtained mesoporous Au has a cubic I4132 mesostructure, which is different from that of the original template, implying that Au was deposited within only one mesochannel of the two interconnected ones. The seed-mediated growth process is a key factor in the successful formation of ordered mesoporous Au using a mesoporous silica template. Our preparative method can serve as a guide for further development of synthetic and materials chemistry of mesoporous Au.
关键词： Gold,Nanostructure,Template synthesis,Mesoporous materials
更新于2025-09-23 15:21:21
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Detection of IL-8 in human serum using surface-enhanced Raman scattering coupled with highly-branched gold nanoparticles and gold nanocages
摘要： Mesoporous materials are ideal carriers for guest molecules and they have been widely used in analytical science. The unique mesoporous structure provides special properties including large specific surface area, tunable pore size, and excellent pore connectivity. The structural properties of mesoporous materials have been largely made use of to improve the performance of analytical methods. For instance, the large specific surface area of mesoporous materials can provide abundant active sites and increase the probability of contact between analytes and active sites to produce stronger signals, thus leading to the improvement of detection sensitivity. The connections between analytical performances and the structural properties of mesoporous materials have not been discussed previously. Understanding the "structure–performance relationship" is highly important for the development of analytical methods with excellent performance based on mesoporous materials. In this review, we discuss the structural properties of mesoporous materials that can be optimized to improve the analytical performance. The discussion is divided into five sections according to the analytical performances: (i) selectivity-related structural properties, (ii) sensitivity-related structural properties, (iii) response time-related structural properties, (iv) stability-related structural properties, and (v) recovery time-related structural properties.
关键词： analytical science,stability,recovery time,response time,structure–performance relationships,selectivity,sensitivity,mesoporous materials
更新于2025-09-11 14:15:04
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Mesoporous titania-coated biosensor and FEM model design for highly sensitive detection of low molecular weight targets
摘要： This paper presents the interest of a highly sensitive biosensor coated with a TiO2 mesoporous film as sensitive layer. The main novelty is related to the modelling of the device and simulation by using Finite Element Method with COMSOL Multiphysics software, as a good way to take into account the physical properties of porous 3D-layers. The strategy of using such Love wave devices, with 3D porous layers, offering further easy functionalization, aims not only to increase the amount of targets caught on the sensor surface, but also to enhance the detection mechanism by a higher perturbation of the Love wave acoustic energy which could be trapped inside the 3D sensitive layer. First, as a proof of concept, experimental devices with a 3D titania mesoporous layer were realized, and they have shown a good agreement with simulated results. Furthermore, experimental test with several Newtonian liquids are investigated, in a range of viscosities from 1 to 7 cP, typical of those concerned by our biochemical applications. The sensitivity with a 300 nm thick porous sensing layer was 10 times that of the bare device, with interesting dynamical issues to be further studied, giving rise to the great potentialities of such architectures for biological detection of low weight biochemical targets.
关键词： surface to volume ratio,mesoporous materials,biochemical sensing,Radio Frequency Love wave device,finite element modelling,acoustic interaction in liquid medium
更新于2025-09-10 09:29:36
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Mix-&-Read Determination of Mercury(II) at Trace Levels with Hybrid Mesoporous Silica Materials Incorporating Fluorescent Probes by a Simple Mix-&-Load Technique
摘要： The synthesis, characterization, and application of mesoporous materials containing boron–dipyrromethene (BODIPY) moieties that allow the sensitive and selective detection of HgII in aqueous environments by fluorescence enhancement is reported. For this purpose, BODIPY dye I containing a thia-aza crown ether receptor as the fluorescent probe for the detection of HgII in aqueous environments is encapsulated into mesoporous materials to avoid self-quenching or aggregation in water. Determination of HgII is accomplished within a few seconds with high selectivity and sensitivity, reaching a limit of detection of 12 ppt. The determination of trace amounts of HgII in natural waters and in fish extracts is demonstrated by using our sensing material. The incorporation of the material into several m-PAD strips yields a portable, cheap, quick, and easy-to-handle tool for trace HgII analysis in water.
关键词： dyes/pigments,mercury,fluorescence,mesoporous materials,test strips
更新于2025-09-09 09:28:46