- 标题
- 摘要
- 关键词
- 实验方案
- 产品
-
The Efficacy of Light Therapy in the Treatment of Seasonal Affective Disorder: A Meta-Analysis of Randomized Controlled Trials
摘要： Background: Bright light therapy (BLT) has been used as a treatment for seasonal affective disorder (SAD) for over 30 years. This meta-analysis was aimed to assess the efficacy of BLT in the treatment of SAD in adults. Method: We performed a systematic literature search including randomized, single- or double-blind clinical trials investigating BLT (≥400 lx) or sham/low-density negative ion generators as placebo. Only first-period data were used from crossover trials. The primary outcome was the post-treatment depression score measured by validated scales, and the secondary outcome was the rate of response to treatment. Results: A total of 19 studies finally met our predefined inclusion criteria. BLT was superior over placebo with a standardized mean difference of –0.37 (95% CI: –0.63 to –0.12) for depression ratings (18 studies, 610 patients) and a risk ratio of 1.42 (95% CI: 1.08–1.85) for response to active treatment (16 studies, 559 patients). We found no evidence for a publication bias, but moderate heterogeneity of the studies and a moderate-to-high risk of bias. Conclusions: BLT can be regarded as an effective treatment for SAD, but the available evidence stems from methodologically heterogeneous studies with small-to-medium sample sizes, necessitating larger high-quality clinical trials.
关键词： Bright light therapy,Seasonal affective disorder,Winter depression,Meta-analysis
更新于2025-09-16 10:30:52
-
Effectiveness of Early Laser Treatment in Surgical Scar Minimization
摘要： BACKGROUND Studies investigating the ef?cacy of lasers to minimize early surgical scars are low powered and report variable results. To further examine the evidence, the authors performed a systemic review and meta-analysis. OBJECTIVE To present the evidence of randomized controlled trials investigating the ef?cacy of laser modalities in minimizing surgical scars when applied <1 month after operation. MATERIALS AND METHODS A literature search of PubMed, EMBASE, Northern Light Life Sciences Conference Abstracts, and Cochrane Library was performed between November 6, 2015, and November 20, 2015. After assessing for inclusion, data extraction used the PRISMA checklist. Assessment for quality, validity, and risk of bias applied a scale devised by Jadad and colleagues, the Oxford Pain Validity Scale, and the RevMan risk of bias assessment tool, respectively. The GRADEpro application graded overall quality, and statistical analysis was performed with RevMan. RESULTS Approximately 4,373/4,397 abstracts and 16/24 full articles were excluded using prede?ned criteria, leaving 8 articles in the systematic review and 4 in the meta-analysis. The primary outcome reached statistical signi?cance favoring the intervention group with standardized mean difference 0.39 (95% con?dence interval, 0.05–0.74) and p = .03. CONCLUSION The outcome supports the ef?cacy of lasers in minimizing primarily closed surgical scars when treated <1 month after surgery.
关键词： surgical scars,laser treatment,randomized controlled trials,meta-analysis,scar minimization
更新于2025-09-12 10:27:22
-
Efficacy of laser therapy for exercise-induced fatigue
摘要： Background: Laser therapy is widely used for exercise-induced fatigue, while the effect among different studies remains controversial. The present study was to summary available randomized controlled trials (RCTs) to evaluate the effect of laser therapy in subjects with exercise-induced fatigue. Methods: PubMed, Embase, and Cochrane Library were searched to identify the potential RCTs from inception to October 2017. The weighted mean difference (WMD) with 95% confidence intervals (CIs) was calculated using a random-effects model. Results: Twenty RCTs involving a total of 394 individuals were included in final analysis. No significant differences were observed between the laser therapy and control for the outcomes of lactate (WMD: (cid:1)0.19; 95%CI: (cid:1)0.52 to 0.13; P = .244), repetitions (WMD: 4.44; 95%CI: (cid:1)1.43 to 10.32; P = .138), work load (WMD: 3.38; 95%CI: (cid:1)1.15 to 7.91; P = .144), time taken to perform the exercise tests (WMD: 4.42; 95%CI: (cid:1)2.33 to 11.17; P = .199), creatine kinase (WMD: (cid:1)41.80; 95%CI: (cid:1)168.78 to 85.17; P = .519), maximum voluntary contraction (WMD: 23.83; 95%CI: (cid:1)7.41 to 55.07; P = .135), mean peak forces (WMD: 2.87; 95%CI: (cid:1)1.01 to 6.76; P = = .147), and visual analog scale (VAS) (WMD: (cid:1)1.91; 95%CI: (cid:1)42.89 to 39.08; P = = .927). The results of sensitivity analysis suggested that laser therapy might play an important role on the levels of lactate (WMD: (cid:1)0.30; 95%CI: (cid:1)0.59 to (cid:1)0.01; P = = .040), maximum voluntary contraction (WMD: 33.54; 95%CI: 1.95 to 65.12; P = = .037), and VAS (WMD: (cid:1)21.00; 95%CI: (cid:1)40.78 to (cid:1)1.22; P = = .037). The results of subgroup analyses indicated no significant differences between the laser therapy and placebo for lactate and repetitions when stratified by study design, mean age, gender, and study quality. Conclusions: The findings of this meta-analysis did not indicate any significant differences between the laser therapy and placebo.
关键词： meta-analysis,laser therapy,exercise-induced fatigue
更新于2025-09-12 10:27:22
-
Clinical attachment level gain of lasers in scaling and root planing of chronic periodontitis: a network meta-analysis of randomized controlled clinical trials
摘要： The objective of this study was to evaluate the clinical attachment level (CAL) gain of Er:YAG, Er,Cr; YSGG, Nd:YAG; and diode laser (DL) as monotherapy or adjunctive to scaling and root planing (SRP) of chronic periodontitis by network meta-analysis (NMA). Randomized controlled clinical trials (RCTs) about lasers applied in SRP of chronic periodontitis were searched from PubMed, Cochrane Library, Web of Science, Ovid, Science Direct, Wan Fang, and China National Knowledge Infrastructure (CNKI) databases up to September 2018 and from references of selected full-texts and related reviews. Standard mean differences and 95% confidence intervals were counted for CAL gain. The random effects NMA were performed in STATA software. There were 25 RCTs about CAL gain at 3 and/or 6 months after lasers were applied in SRP. No inconsistency was detected. Er:YAG as monotherapy gained significantly more CAL at 3 months than did SRP; no significant differences were detected among other comparisons. In terms of CAL gain at 3 months, the ranking result from best to worst was as follows: Er:YAG as monotherapy, DL adjunctive to SRP, Er:YAG adjunctive to SRP, Er,Cr;YSGG as monotherapy, Nd:YAG adjunctive to SRP, and SRP. In terms of CAL gain at 6 months, the ranking result from best to worst was as follows: DL adjunctive to SRP, Nd:YAG adjunctive to SRP, SRP, Er:YAG adjunctive to SRP, and Er:YAG as monotherapy. Laser-assisted periodontal treatment could be superior to SRP alone and could serve as a good adjunctive treatment tool.
关键词： Network meta-analysis,Lasers,Scaling and root planing,Chronic periodontitis
更新于2025-09-12 10:27:22
-
Diagnostic accuracy of laser Doppler imaging for the assessment of burn depth: a meta-analysis and systematic review
摘要： An overall assessment of the diagnostic value of laser Doppler imaging (LDI) to assess burn depth in patients is presented based on relevant studies. Both eligible research and relevant articles were identified through specific index searches of Embase, Cochrane and PubMed databases. The latest study included was published in March 2019 and all eligible publications reported on cohort or cross-sectional research. All articles were tested for heterogeneity by using a suitable effect model to calculate amalgamative values of sensitivity, specificity and the diagnostic odds ratio (DOR). Analyses of summary receiver operating characteristic (SROC) are given for burn depth values. After rigorous screening, 14 studies with a total cohort of 1,818 patients were chosen for the meta-analysis to explore the validity of LDI diagnosis to assess the depth of burns. The burn depth overall sensitivity for LDI was 91% (95% CI: 86-95%) and global specificity was 96% (95% CI: 92-98%). The overall positive likelihood ratio of LDI was 20.35 (95% CI: 10.71-38.69) and the overall negative likelihood ratio was 0.09 (95% CI: 0.05-0.15). The overall DOR was 152.93 (95% CI: 69.44-336.81) of LDI. The acreage under the SROC was not low for LDI (AUC = 0.98; 95% CI: 0.96-0.99). In conclusion, the present analysis reviewed the literature and meta-analysis of studies to validate LDI for the diagnosis of burn depth. The results indicated that LDI has a high accuracy for this diagnostic function.
关键词： diagnostic accuracy,burn depth,meta-analysis,laser Doppler imaging (LDI)
更新于2025-09-12 10:27:22
-
Clinical outcomes of small incision lenticule extraction versus femtosecond laser-assisted LASIK for myopia: a Meta-analysis
摘要： ● AIM: To evaluate the possible differences in visual quality between small incision lenticule extraction (SMILE) and femtosecond laser in situ keratomileusis (FS-LASIK) for myopia. ● METHODS: A Meta-analysis was performed. Patients were from previously reported comparative studies treated with SMILE versus FS-LASIK. The PubMed, EMBASE, Cochrane, Web of Science and Chinese databases (i.e. WANFANG and CNKI) were searched in Nov. of 2016 using RevMan 5.1 version software. The differences in visual acuity, aberration and biomechanical effects within six months postoperatively were showed. Twenty-seven studies including 4223 eyes were included. ● RESULTS: No significant differences were observed between SMILE and FS-LASIK in terms of the proportion of eyes that lost one or more lines of corrected distance visual acuity after surgery (P=0.14), the proportion of eyes achieving an uncorrected distance visual acuity of 20/20 or better (P=0.43), the final refractive spherical equivalent (P=0.89), the refractive spherical equivalent within ±1.00 diopter of the target values (P=0.80), vertical coma (P=0.45) and horizontal coma (P=0.06). Compared with the FS-LASIK group, total higher-order aberration (P<0.001) and spherical aberration (P<0.001) were higher and the decrease in corneal hysteresis (P=0.0005) and corneal resistance factor (P=0.02) were lower in the SMILE group. ● CONCLUSION: SMILE and FS-LASIK are comparable in efficacy, safety and predictability for correcting myopia.
关键词： Meta-analysis,small incision lenticule extraction,myopia,femtosecond laser in situ keratomileusis
更新于2025-09-11 14:15:04