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Investigation of the Salt Concentration Dependence of Water-Gated Field Effect Transistors (WG-FET) Using 16-nm-Thick Single Crystalline Si Film
摘要： This paper presents the effect of NaCl concentration on the operation of a water-gated field effect transistor (WG-FET) that uses 16-nm-thick single crystalline silicon (Si) film. In WG-FET, electrical double layer (EDL) formed at the water/silicon interface behaves as gate dielectric and this fluidic interface makes WG-FET a suitable device for sensing applications. Characteristics of EDL and the threshold voltage of WG-FET depend on the molarity of solution. Increasing the molarity of NaCl solution from 0.5 to 65 mM changes the threshold voltage from 360 to 465 mV. Accordingly, drain current of the WG-FET device changes with NaCl concentration.
关键词： water-gated transistor,electrical double layer,microfluidic interface,salt sensor
更新于2025-09-09 09:28:46
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Continuous Synthesis of Monodisperse Yolk-Shell Titania Microspheres
摘要： A microfluidic strategy is developed for continuous synthesis of monodisperse yolk-shell titania microspheres. The continuous flow synthesis of titania microparticles is achieved by decoupling the microdroplet formation and interfacial hydrolysis reaction steps by utilizing a polar aprotic solvent as the continuous phase in the microreactor. The decoupling of the precursor microdroplet formation and the hydrolysis reaction allows titania synthesis throughputs an order of magnitude higher than those previously reported in a single-channel flow reactor (~0.1 g/h calcined microparticles), without affecting the microreactor lifetime due to clogging. Flow synthesis and dynamics across a broad range of precursor flow rates are examined, while effects of flow synthesis parameters, including the precursor to continuous phase flow rate ratio, precursor composition, and calcination temperature on the surface morphology, size, and composition of the resulting titania microparticles are explored in detail. Titania microparticle size can be controlled by variation in the precursor to continuous phase flow rate ratio. The surface morphology and porosity of the in-flow synthesized titania microparticles can be varied by adjusting the precursor composition, while crystalline phase can be tuned by varying the calcination temperature.
关键词： continuous synthesis,titania,microfluidic,yolk-shell,monodisperse
更新于2025-09-09 09:28:46
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Portable Smartphone-Based Platform for Real-Time Particle Detection in Microfluidics
摘要： Real-time particle detection is an integral part of microfluidics for diagnostics. The detection method is typically performed with the use of bulky and expensive instruments including a bench-top microscope, high-speed camera, and fluidic pump. This limits the practical applications of microfluidics for real-time point-of-care detection. Here, a portable and low-cost smartphone microscopy platform is developed for real-time particle detection in microfluidics based on a polydimethylsiloxane (PDMS) lens, modular 3D printed accessory, plug-and-play paper pump, and a novel particle counting algorithm. The PDMS lens is developed using a new method based on the PDMS precuring and hydrophobic modification on a pillar template to allow for fabrication of various lens shapes with high reproducibility and broad range magnification ratio from 30× to 100×. The modular 3D printed smartphone accessory allows for easy imaging setup to cater for different size of microchannel and the paper pump design provides a convenient single-step process to drive the fluid. The platform is implemented to count the moving particles in the outlet of microfluidics deterministic lateral displacement with 94% counting accuracy. This platform provides huge potential applications for real-time point-of-care detection that can be integrated with various microfluidic techniques.
关键词： particle counting,microfluidic,smartphone microscope,PDMS lens,paper pump
更新于2025-09-09 09:28:46
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Enabling liquid vapor analysis using synchrotron VUV single photon ionization mass spectrometry with a microfluidic interface
摘要： Vacuum ultraviolet (VUV) single photon ionization mass spectrometry (SPI-MS) is a vacuum-based technique typically used for the analysis of gas phase and solid samples, but not for liquids due to the challenge in introducing volatile liquids in a vacuum. Here we present the first demonstration of in situ liquid analysis by integrating the System for Analysis at the Liquid Vacuum Interface (SALVI) microfluidic reactor into VUV SPI-MS. Four representative volatile organic compound (VOC) solutions were used to illustrate the feasibility of liquid analysis. Our results show the accurate mass identification of the VOC molecules and the reliable determination of appearance energy that is consistent with ionization energy for gaseous species in the literature as reported. This work validates that the vacuum-compatible SALVI microfluidic interface can be utilized at the synchrotron beamline and enable the in situ study of gas-phase molecules evaporating off the surface of a liquid, which holds importance in the study of condensed matter chemistry.
关键词： SALVI,VUV single photon ionization mass spectrometry,microfluidic interface,liquid vapor analysis,volatile organic compounds
更新于2025-09-04 15:30:14
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Separation of Biological Particles in a Modular Platform of Cascaded Deterministic Lateral Displacement Modules
摘要： Deterministic lateral displacement (DLD) has been extensively implemented in the last decade for size-based sample preparation, owing to its high separation performances for a wide range of particle dimensions. However, separating particles from 1 μm to 10 μm in one single DLD device is challenging because of the required diversity of pillar dimensions and inherent fabrication issues. This paper presents an alternative approach to achieve the extraction of E. coli bacteria from blood samples spiked with prostate cancer cells. Our approach consists in cascading individual DLD devices in a single automated platform, using flexible chambers that successively collect and inject the sample between each DLD stage without any external sample manipulation. Operating DLD separations independently enables to maximize the sorting efficiency at each step, without any disturbance from downstream stages. The proposed two-step automated protocol is applied to the separation of three types of components (bacteria, blood particles and cancer cells), with a depletion yield of 100% for cancer cells and 93% for red blood cells. This cascaded approach is presented for the first time with two DLD modules and is upscalable to improve the dynamic range of currently available DLD devices.
关键词： Deterministic lateral displacement,DLD,blood samples,E. coli,prostate cancer cells,particle separation,microfluidic
更新于2025-09-04 15:30:14
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[IEEE 2018 IEEE 18th International Conference on Bioinformatics and Bioengineering (BIBE) - Taichung, Taiwan (2018.10.29-2018.10.31)] 2018 IEEE 18th International Conference on Bioinformatics and Bioengineering (BIBE) - Nonlinear CMOS Image Sensor with SOC Integrated Local Contrast Stretch for Bio-Microfluidic Imaging
摘要： a nonlinear single-slope ADC with SOC integrated local contrast stretch using a configurable multi-frequency counter for bio-microfluidic imaging is presented in this paper. Compared with the conventional off-chip global contrast stretching algorithm, this method does not degrade image quality at the interested light intensity range (cell) at the cost of unconsidered range (sheath fluid) and can be integrated into CMOS image sensor directly. Meanwhile, this method provides higher precision of cell image for the later super-resolution reconstruction. The simulation results indicate that more details of cell image can be obtained in this method.
关键词： contrast stretch,CMOS image sensor,point-of-care (POC) diagnosis,bio-microfluidic imaging
更新于2025-09-04 15:30:14