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MAPbI <sub/>3</sub> Self‐Recrystallization Induced Performance Improvement for Oxygen‐Containing Functional Groups Decorated Carbon Nanotube‐Based Perovskite Solar Cells
摘要： The specific interactions (i.e., molecular recognitions) between receptors at membrane and ligands at the extracellular matrix (ECM) are crucial in various cellular processes [1]. The occurrence of these molecular recognitions as a consequence of ECM remodeling gives rise to specific cell-signaling and intracellular cascades. Therefore the natural receptor(cid:1)ligand interactions are central in physiology and pathological processes. From the point of view of materials science, the specific binding of natural receptors to targeted ligands also shows great promise in the design of biomaterials with advanced affinity [2]. Despite the successful development of a plethora of biomaterials or biomedical devices based on natural receptor(cid:1)ligand interactions in the last decade, natural species like proteins or DNAs still have inherent drawbacks [3,4]. First, the chemical and physical stability and shelf life of natural receptors or antibodies are limited, which restricts their applications in nonphysiological environments. Second, it is expensive, time-consuming, and labor-intensive to isolate and purify them from nature or by biochemical synthesis. Finally, practical requirements in materials science are more extensive than the limited yield, functions, and diversity in currently available molecular recognition in nature. As a result, an advanced material design with more durable and robust receptor-like substitutions is sought [5].
关键词： Bioaffinity,Synthetic Receptors,Affinity Screening,Molecular Imprinting,Biomedical Applications
更新于2025-09-19 17:13:59
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Development of Rapid, Sensitive, and Effective Plasmonic Nanosensor for the Detection of Vitamins in Infact Formula and Milk Samples
摘要： The aim of the present study is to develop a surface plasmon resonance sensor for the detection of vitamin B2, vitamin B9, and vitamin B12 in food samples by using the molecular imprinting technique. The vitamin B2, vitamin B9, and vitamin B12 imprinted and the non-imprinted surface plasmon resonance sensor chip surfaces were characterized by using contact angle measurements, atomic force microscopy, ellipsometry, and Fourier transform infrared-attenuated total reflectance. The real-time detection of vitamin B2, vitamin B9, and vitamin B12 was analyzed by using aqueous solutions in the concentration range of 0.01 ng/mL ? 10 ng/mL for vitamin B2, 0.1 ng/mL ? 8.0 ng/mL for vitamin B9, and 0.01 ng/mL ? 1.5 ng/mL for vitamin B12. The limit of detection values was calculated as 1.6×10?4 ng/mL for vitamin B2, 13.5×10?4 ng/mL for vitamin B9, and 2.5×10?4 ng/mL for vitamin B12, respectively. Selectivity experiments were performed by using vitamin B1 and vitamin B6. The reproducibility of surface plasmon resonance sensors was investigated both on the same day and on different days for four times. Validation studies of the surface plasmon resonance sensors were performed by liquid chromatography-tandem mass spectrometry (LC-MS/MS).
关键词： surface plasmon resonance,Vitamin,food samples,molecular imprinting
更新于2025-09-19 17:13:59
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Simple preparation of fluorescence probe based on CdTe quantum dots combined with MIP for selective detection of sulfadimidine
摘要： A simple fluorescence sensor for the detection of sulfadimidine (SM2) was fabricated by molecular imprinting technology. Cadmium telluride quantum dots (CdTe QDs) as the fluorescent material, 3-aminopropyltriethoxysilane (APTES) as functional monomer, sulfadimidine as template molecule and tetraethoxysilane (TEOS) as cross-linker, the CdTe QDs were embedded in silica nano-particles by reverse microemulsion method. Under optimal detection condition, response is linear in the 2–30 μmol L?1 SM2 concentration condition with the detection limit was 0.4 μmol L?1. In addition, the correlation coefficient was 0.9857 and the imprinting factor was 4.82. The fluorescent probe was successfully applied to the determination of SM2 in tap water and milk sample with the spiked recoveries ranging from 99.8 to 103.2%. It gets a good specific recognition ability and potential practical application value.
关键词： reverse microemulsion method,molecular imprinting technology,sulfadimidine,CdTe quantum dots,fluorescence sensor
更新于2025-09-12 10:27:22
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Molecularly Imprinted Fluorescent Test Strip for Direct, Rapid, and Visual Dopamine Detection in Tiny Amount of Biofluid
摘要： Paper-based assays for detection of physiologically important species are needed in medical theranostics owning to their superiorities in point of care testing, daily monitoring, and even visual readout by using chromogenic materials. In this work, a facile test strip is developed for visual detection of a neurotransmitter dopamine (DA) based on dual-emission fluorescent molecularly imprinted polymer nanoparticles (DE-MIPs). The DE-MIPs, featured with tailor-made DA affinity and good anti-interference, exhibit DA concentration-dependent fluorescent colors, due to the variable ratios of dual-emission fluorescence caused by DA binding and quenching. By facile coating DE-MIPs on a filter paper, the DA test strips are obtained. The resultant test strip, like the simplicity of a pH test paper, shows the potential for directly visual detection of DA levels just by dripping a tiny amount of biofluid sample on it. The test result of real serum samples demonstrates that the DA strip enables to visually and semiquantitatively detect DA within 3 min by using only 10 μL of serum samples and with a low detection limit ((100–150) × 10?9 m) by naked eye. This work thus offers a facile and efficient strategy for rapid, visual, and on-site detection of biofluids in clinic.
关键词： molecular imprinting,dual-emission fluorescence,visual detection,paper-based assays,dopamine
更新于2025-09-10 09:29:36
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Detection of Benzene and Volatile Aromatic Compounds by Molecularly Imprinted Polymer Coated Quartz Crystal Microbalance Sensor
摘要： The detection of benzene and its analogues are important but difficult without using expensive extremely analytical instruments. The present work reports the detection of aromatic hydrocarbons like benzene, toluene and isomers of xylene using quartz crystal microbalance (QCM) sensor. The surface of a silver-coated quartz crystal was coated with a simple solution drop coating method and thermally polymerized in an inert atmosphere for the formation of the sensing film. The polymer was synthesized by copolymerization of the optimum ratio of styrene, divinylbenzene and tung oil at 90°C with template. 1, 2, 3 trimethoxybenzene as template performed most efficiently for all the hydrocarbons. Linear calibration curves were observed for all the vapors in the concentration range between approximately as 1.645 to 2.605 Hz/ppm. For benzene, the sensitivity is 2.605 Hz /ppm which is the highest amongst the reported literature. Thus minimum concentration of benzene that can be detected is 0.98 ppm. The molecularly imprinted polymer structure and surface morphology were analyzed by FTIR spectroscopy, FESEM and AFM. The sensitivity of detection of aromatic molecule in this work by the molecularly imprinted polymer film is found to be the best amongst the reported literatures.
关键词： molecular imprinting technique,thermal polymerization,vegetable oil,Quartz Crystal Microbalance (QCM),aromatic hydrocarbons
更新于2025-09-10 09:29:36
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Post-imprinting-modified molecularly imprinted nanocavities with two synergetic, orthogonal, glycoprotein-binding sites to transduce binding events into fluorescence changes
摘要： We developed sensitive and selective polymeric nanocavities for glycoprotein detection using a novel molecular imprinting technique involving post-imprinting modification (PIM). It allowed the introduction of two different interaction sites and a fluorescent reporter within each nanocavity. The hepatocellular carcinoma biomarker α-fetoprotein (AFP) was used as a model glycoprotein. For PIM-based molecular imprinting, AFP conjugated with polymerizable groups by disulfide bonding was prepared and immobilized on a 4-carboxy-3-fluorophenylboronic acid-immobilized substrate by cyclic diester formation between AFP glycans in an oriented immobilization manner, facilitating the creation of homogeneous AFP-imprinted nanocavities. Surface-initiated controlled/living radical polymerization was performed with a functional monomer, co-monomer, and crosslinker. The disulfide bonds and cyclic diesters were cleaved to create AFP-imprinted nanocavities, generating free thiol groups present inside the nanocavities only. A thiol-reactive fluorescent dye was added to the nanocavities by in-cavity PIM, yielding signaling AFP-imprinted nanocavities capable of transducing AFP-binding events into fluorescence changes. Reference proteins showed little response, while the limit of detection of AFP was 0.27 ng/mL (ca. 3.9 pM) in diluted human serum. Thus, the proposed in-cavity PIM-based molecular imprinting technique is effective for ELISA-relevant, antibody-free sensing systems for glycoproteins.
关键词： molecular recognition,molecular imprinting,sensors,glycoproteins,post-imprinting modification
更新于2025-09-04 15:30:14