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[IEEE TENCON 2019 - 2019 IEEE Region 10 Conference (TENCON) - Kochi, India (2019.10.17-2019.10.20)] TENCON 2019 - 2019 IEEE Region 10 Conference (TENCON) - Use of Novel Hybrid Plasmonic Nanoparticle Complexes to Increase the Efficiency of Thin-film Solar Cells
摘要： To utilize the synergy between computed tomography (CT) and magnetic resonance imaging (MRI) data sets from an object at the same time, an edge-guided dual-modality image reconstruction approach is proposed. The key is to establish a knowledge-based connection between these two data sets for the tight fusion of different imaging modalities. Our scheme consists of four inter-related elements: 1) segmentation; 2) initial guess generation; 3) CT image reconstruction; and 4) MRI image reconstruction. Our experiments show that, aided by the image obtained from one imaging modality, even with highly under-sampled data, we can better reconstruct the image of the other modality. This approach can be potentially useful for a simultaneous CT-MRI system.
关键词： l1-norm minimization,image reconstruction,CT-MRI system,multi-modality imaging
更新于2025-09-23 15:19:57
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Human Umbilical Cord Wharton's Jelly-derived Mesenchymal Stem Cells Labeled with Mn2+ and Gd3+ Co-doped CuInS2-ZnS Nanocrystals for Multi-modality Imaging in Tumor Mice Model
摘要： Mesenchymal stem cells (MSCs) therapy has recently received profound interest as a targeting-platform in cancer-theranostics due to inherent tumor-homing abilities. However, the terminal tracking of MSCs-engraftment by fluorescent in situ hybridization, immuno-histochemistry and flow-cytometry techniques to translate into clinics are still challenging due to dearth of inherent MSC-specific markers and FDA-approval for genetic-modifications of MSCs. To address this challenge, a cost-effective non-invasive imaging technology based on multi-functional nanocrystals (NCs) with enhanced-detection sensitivity, spatial-temporal resolution, deep-tissue diagnosis is needed to be developed to track the transplanted stem cells. A hassle-free labeling of human umbilical-cord Wharton’s-Jelly (WJ)-derived MSCs with Mn2+ and Gd3+ co-doped CuInS2-ZnS (CIS-ZMGS) NCs has been demonstrated in 2 h without requiring electroporation process or transfection agents. It has been found that, WJ-MSCs labeling did not affect their multi-lineage differentiation (adipocyte, osteocyte, chondrocyte), immuno-phenotypes (CD44+, CD105+, CD90+), protein (β-actin, vimentin, CD73, α-SMCA) and gene-expressions. Interestingly, CIS-ZMGS-NCs labeled WJ-MSCs exhibit near-infrared fluorescence (NIR) with quantum yield (QY) of 84%, radiant intensity ~3.999 x 1011 (p/sec/cm2/sr)/(μW/cm2), magnetic relaxivity (longitudinal r1=2.26 mM-1s-1, transverse r2=16.47 mM-1s-1) and X-ray attenuation (78 HU) potential for early non-invasive multi-modality imaging of a subcutaneous-melanoma in B16F10-tumor-bearing C57BL/6-mice in 6 h. The ex vivo imaging and inductively-coupled plasma mass-spectroscopy (ICP-MS) analyses of excised organs along with confocal-microscopy and immuno-fluorescence of tumor results also significantly confirmed positive-tropism of CIS-ZMGS-NCs labeled WJ-MSCs in the tumor-environment. Hence, we propose the magneto-fluorescent CIS-ZMGS-NCs labeled WJ-MSCs as a next-generation nano-bioprobe of three commonly used imaging-modalities for stem cells-assisted anti-cancer therapy and tracking tissue/organ regenerations.
关键词： multi-modality imaging,stem cell labeling,CuInS2-ZnS,in vivo tracking,microwave refluxing
更新于2025-09-12 10:27:22