- 标题
- 摘要
- 关键词
- 实验方案
- 产品
-
Photobiomodulation Therapy is Able to Modulate PGE <sub/>2</sub> Levels in Patients With Chronic Nona??Specific Low Back Pain: A Randomized Placeboa??Controlled Trial
摘要： Background and Objectives: Non‐specific low back pain (LBP) is responsible for triggering increased biomarkers levels. In this way, photobiomodulation therapy (PBMT) may be an interesting alternative to treat these patients. One of the possible biological mechanisms of PBMT involved to decrease pain intensity in patients with musculoskeletal disorders is modulation of inflammatory mediators’ levels. The aim of this study was to evaluate the effects of PBMT compared with placebo on inflammatory mediators’ levels and pain intensity in patients with chronic non‐specific LBP. Study Design/Materials and Methods: A prospectively registered, randomized triple‐blinded (volunteers, therapists, and assessors), placebo‐controlled trial was performed. Eighteen patients with chronic non‐specific LBP were recruited and treated with a single session of active PBMT or placebo PBMT. The primary outcome of the study was serum prostaglandin E2 levels and the secondary outcomes were tumor necrosis factor‐α, interleukin‐6 levels, and pain intensity. All outcomes were measured before and after 15 minutes of treatment session. Results: PBMT was able to decrease prostaglandin E2 levels at post‐treatment compared with placebo, with a mean difference of ?1470 pg/ml, 95% confidence interval ?2906 to ?33.67 in patients with LBP. There was no difference between groups in the other measured outcomes. Patients did not report any adverse events. Conclusion: Our results suggest that PBMT was able to modulate prostaglandin E2 levels, indicating that this may be one of the mechanisms involved in the analgesic effects of PBMT in patients with LBP.
关键词： low‐level laser therapy,inflammatory mediators,low back pain,physical therapy,rehabilitation,musculoskeletal disorders
更新于2025-09-23 15:19:57
-
PET-Computed Tomography and PET-MR Imaging and Their?Applications in the Twenty-First Century
摘要： Since the discovery of x-ray by Roentgen in 1895, planar radiography has remained a major imaging technique in assessing skeletal abnormalities with reasonable success. However, poor contrast between diseased sites and the background results in low sensitivity of this modality in detecting early disease and monitoring its course over time. The introduction of computed tomography (CT) in 1971 by Hounsfield further enhanced the role of x-ray-based disease assessment, and as such, XCT has played an important role in the day-to-day management of musculoskeletal (MSK) disorders. Since the early 1980s, when the first MR imaging instruments were introduced for human studies, the impact of imaging for examining soft tissue abnormalities in MSK disorders has been substantially enhanced. Currently, XCT and MR imaging are the main imaging modalities available in this domain but suffer from many deficiencies that need to be addressed by employing more advanced approaches. Since the early 1970s, 99m-Technitium (Tc)-labeled phosphates have been extensively used to detect benign and malignant disorders of the skeletal system. These radiotracers allow planar and tomographic imaging (SPECT [single-photon emission computed tomography]), but the quality of images generated is somewhat suboptimal for detection of the affected sites and quantification of the disease activity.
关键词： PET-CT-MRI,musculoskeletal disorders,radiotracers,FDG-PET,imaging,18F-NaF
更新于2025-09-09 09:28:46