- 标题
- 摘要
- 关键词
- 实验方案
- 产品
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Immobilization of Detonation Nanodiamonds on Macroscopic Surfaces
摘要： Detonation nanodiamonds (NDs) are a novel class of carbon-based nanomaterials, and have received a great deal of attention in biomedical applications, due to their high biocompatibility, facile surface functionalization, and commercialized synthetic fabrication. We were able to transfer the NDs from large-size agglomerate suspensions to homogenous coatings. ND suspensions have been used in various techniques to coat on commercially available substrates of pure Ti and Si. Scanning electron microscopy (SEM) imaging and nanoindentation show that the densest and strongest coating of NDs was generated when using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide and N-hydroxysuccinimide (EDC/NHS)-mediated coupling to macroscopic silanized surfaces. In the next step, the feasibility of DNA-mediated coupling of NDs on macroscopic surfaces is discussed using fluorescent microscopy and additional particle size distribution, as well as zeta potential measurements. This work compares different ND coating strategies and describes the straightforward technique of grafting single-stranded DNA onto carboxylated NDs via thioester bridges.
关键词： detonation nanodiamonds,bio-conjugation,fluorescent microscopy,de-agglomeration,nanoindentation
更新于2025-11-21 11:24:58
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Carbon Allotropes: Metal-Complex Chemistry, Properties and Applications || Classic Carbon Nanostructures
摘要： The era of carbon-based nanotechnology, as it is well-known, started from 1985 when the fullerene C60 was discovered. The rediscovery of carbon nanotubes and unexpected discovery of graphene gave a powerful impulse to the further development of carbon nanostructures. At present, these nanocarbons, as well as nanodiamonds or nanofibers, can already be considered as 'conventional' carbon nanostructures.
关键词： nanofibers,nanodiamonds,carbon nanotubes,graphene,carbon nanostructures,fullerenes
更新于2025-09-23 15:23:52
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[IEEE 2018 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO) - Hangzhou, China (2018.8.13-2018.8.17)] 2018 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO) - Bottom up Nano-integration Technique for the Fabrication of Novel Superconducting Quantum Interference Devices Based on Granular Superconducting Diamond
摘要： The report is focused on the fabrication and characterization of nano-necklaces created from individual nanostructures namely heavily boron-doped superconducting nano-diamond grains and BIISCO whiskers. The production of nanostructures from individual nano-diamonds is done using 3D mechanical nano-manipulation and nano-assembling based on new generation shape memory alloy composite nanotweezers. Quantum transport of such nano-necklaces will be probed in order to study the confinement effects on superconductivity and other related quantum effects. This bottom-up nano-integration technique thus demonstrates a niche fabrication route for the realization of novel complex nanostructured quantum rings which may be of use for quantum information technologies.
关键词： nanodiamonds,bottom-up paradigm,carbon based nanomaterials,nanogripper,shape memory effect,nano-manipulation,superconductivity
更新于2025-09-23 15:23:52
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Fluorescent Nanodiamonds || Color Centers in Diamond
摘要： In this chapter, we will discuss the key features of nanodiamonds that are relevant to the development of fluorescent nanodiamonds (FNDs) and their many uses in biotechnology and beyond. Up till now, we have surveyed nanotechnology in previous chapters starting with its historical development and focusing, in particular, on the nanocarbon materials. With a general introduction to nanodiamonds (Chapter 2), we have learned some methods commonly used to prepare man‐made diamonds and the fundamental properties shared by all diamonds and nanodiamonds alike. In this and the following two chapters, we are about to find out that nanodiamonds can glow (Chapter 3), support (Chapter 4), and is safe to use (Chapter 5). These unique features have made nanodiamonds a superior material for a fast‐growing list of applications at present time and in the coming future.
关键词： biotechnology,fluorescent nanodiamonds,diamond,nanodiamonds,color centers
更新于2025-09-23 15:21:01
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Nanoscale magnetic imaging enabled by nitrogen vacancy centres in nanodiamonds labelled by iron-oxide nanoparticles
摘要： Nanodiamonds containing the nitrogen vacancy centre (NV) have a significant role in biosensing, bioimaging, drug delivery, and as biomarkers in fluorescence imaging, due to their photo-stability and biocompatibility. The optical read out of the NV unpaired electrons spin has been used in diamond magnetometry to image living cells and magnetically labelled cells. Diamond magnetometry is mostly based on the use of bulk diamond with a large concentration of NV centres in a wide field fluorescence microscope equipped with microwave excitation. It is possible to correlate the fluorescence maps with the magnetic field maps of magnetically labelled cells with diffraction limit resolution. Nanodiamonds have not as yet been implemented to image magnetic fields within complex biological systems at the nanometre scale. Here we demonstrate the suitability of nanodiamonds to correlate the fluorescence map with the magnetic imaging map of magnetically labelled cells. Nanoscale optical images with 17 nm resolution of nanodiamonds labelling fixed cells bound to iron oxide magnetic nanoparticles are demonstrated by using a single molecule localisation microscope. Nanoscale magnetic field images of the magnetised magnetic nanoparticles spatially assigned to individual cells are superresolved by the NV centres within nanodiamonds conjugated with the magnetic nanoparticles with 20 nm resolutions. Our method offers a new platform for super-resolution of optical magnetic imaging in biological samples conjugated with nanodiamonds and iron-oxide magnetic nanoparticles.
关键词： spin detection,superresolution,Nitrogen-vacancy centre,optical magnetic imaging,nanodiamonds
更新于2025-09-23 15:21:01
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Absorption spectra of nanodiamond aqueous dispersions by optical absorption and optoacoustic spectroscopies
摘要： The multispectral modality and technique for optically dense samples of optoacoustic spectroscopy were applied to measure spectra and high absorbances of concentrated aqueous dispersions of undoped nanodiamonds. The data from optoacoustic and optical transmission measurements and DSC data of the mean particle size by the Gibbs–Kelvin equation are compared to estimate the difference in composition of various nanodiamond trademarks. Optoacoustic spectra confirm the contribution of surface dimer chains into the absorption of nanodiamonds in the long wavelength range. Optoacoustic and conventional absorption spectra of aqueous solutions of nanodiamond fractions after centrifugation (15 300g) and ultracentrifugation (130 000g) revealed a separation of a highly absorbing non-diamond sp2 phase. The two-step separation by ultracentrifugation followed by extra centrifugation made it possible to isolate a highly absorbing and soluble nanodiamond phase with the particle size of 3.6 nm, showing a change in spectra compared to the starting nanodiamond material.
关键词： nanodiamond aqueous dispersions,nanodiamonds,optically dense samples,nanodiamond fractionation,optoacoustic spectroscopy,multispectral optoacoustic spectroscopy
更新于2025-09-23 15:21:01
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Fluorescent Nanodiamonds || Producing Fluorescent Nanodiamonds
摘要： Natural diamonds in colors are commonly known as fancies, or fancy color diamonds, in gemstone industries. They are rare, beautiful, and some even carry impressive price tags in the jewelry market. By comparison, micro‐ and nanoscale diamond powders are low in price, with or without colors and fluorescent or not. These powders have been used as abrasives for grinding and polishing purposes since ancient time, mainly because of their extraordinary hardness. Little or no attention has been paid over the centuries to other properties of nanodiamonds such as their innate biocompatibility and light‐emitting capability. The invention of fluorescent nanodiamond (FND) in 2005 has revolutionized the field, opening a new area of research and development with diamonds. Experiments with FNDs in the last decade have demonstrated various promising applications of surface‐functionalized FNDs in diversified fields, ranging from physics and chemistry to biology and medicine. It is worthy of noting that as originated from the discovery of Radium by Marie Sk?odowska Curie (Section 3.2), FNDs may very well be called Madame Curie’s gemstones, valued appropriately as a scientist’s best friend.
关键词： fluorescent nanodiamonds,magnetically modulated fluorescence,fluorescence lifetime,size reduction,FND,ion irradiation,H3 centers,nitrogen-vacancy centers,electron irradiation,NV centers
更新于2025-09-23 15:21:01
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Fluorescent Nanodiamonds || Cell Labeling and Fluorescence Imaging
摘要： Nanocarbons are a family consisting of fullerenes, carbon nanotubes, graphenes, nanodiamonds, and other variations. Fluorescent nanodiamonds (FNDs) joined the family in 2005. While receiving less attention than other members of the family, FNDs are gaining popularity as a novel nanoparticle platform for biomedical applications in recent years. An ideal biomedical nanoparticle platform should possess three functionalities: targeting, imaging, and therapeutic. Of course, the nanoparticles must be endowed with high biocompatibility and low cytotoxicity. As evident from all the discussions so far in this book, surface‐functionalized FND clearly meets all these requirements. Applying the platform to biomedical studies is expected to enhance our understanding of the pathophysiological basis of disease, open up more sophisticated diagnostic opportunities, and lead to improved therapies and treatments.
关键词： Imaging,Targeting,Fluorescent nanodiamonds,Nanocarbons,Therapeutic,Biomedical applications
更新于2025-09-23 15:21:01
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Fluorescent Nanodiamonds || Cell Tracking and Deep Tissue Imaging
摘要： Cell labeling, both specific and nonspecific, discussed in the previous chapter belongs in part to the field of cell therapy, defined as 'administration of live whole cells or maturation of a specific cell population in a patient for the treatment of a disease'. Cell therapy is an emerging field in the medical research as a promising treatment option for human injuries and diseases. While the first use of cells for therapeutic purposes can be traced to the nineteenth century, much is still lacking in our knowledge of the therapy, including the biodistribution, pharmacokinetics, and pharmacodynamics of transplanted human cells in vivo. Such knowledge is essential for detailed understanding of the cells' development, fate, and contribution to regenerating tissues prior to clinical trials.
关键词： cell tracking,cell therapy,fluorescent nanodiamonds,deep tissue imaging,nanotechnology
更新于2025-09-23 15:21:01
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Controlling the fluorescence properties of nitrogen vacancy centers in nanodiamonds
摘要： Controlling the fluorescence properties of nitrogen vacancy centers in nanodiamonds is an important factor for their use in medical and sensor applications. However, reports providing a deep understanding of the potential factors influencing these properties are rare and focus only on a few influencing factors. The current contribution targets this issue and we report a comprehensive study of the fluorescence properties of NVs in nanodiamonds as a function of electron irradiation fluence and surface termination. Here we show that process parameters such as defect center interactions, in particular, different nitrogen defects and radiation induced lattice defects, as well as surface functionalities have a strong influence on the fluorescence intensity, fluorescence lifetime and the charge state ratio of the NV centers. By employing a time-correlated single photon counting approach we also established a method for fast macroscopic monitoring of the fluorescence properties of ND samples. We found that the fluorescence properties of NV centers may be controlled or even tuned depending upon the radiation treatment, annealing, and surface termination.
关键词： fluorescence lifetime,charge state ratio,nanodiamonds,surface termination,nitrogen vacancy centers,fluorescence properties,electron irradiation
更新于2025-09-19 17:15:36