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Development and first in-human use of a Raman spectroscopy guidance system integrated with a brain biopsy needle
摘要： Navigation-guided brain biopsies are the standard of care for diagnosis of several brain pathologies. However, imprecise targeting and tissue heterogeneity often hinder obtaining high-quality tissue samples, resulting in poor diagnostic yield. We report the development and first clinical testing of a navigation-guided fiberoptic Raman probe that allows surgeons to interrogate brain tissue in situ at the tip of the biopsy needle, prior to tissue removal. The 900μm diameter probe can detect high spectral quality Raman signals in both the fingerprint and high wavenumber spectral regions with minimal disruption to the neurosurgical workflow. The probe was tested in 3 brain tumor patients, and the acquired spectra in both normal brain and tumor tissue demonstrated the expected spectral features, indicating the quality of the data. As a proof-of-concept, we also demonstrate the consistency of the acquired Raman signal with different systems and experimental settings. Additional clinical development is planned to further evaluate the performance of the system and develop a statistical model for real-time tissue classification during the biopsy procedure.
关键词： biopsy,cancer,neurosurgery,optical systems,Raman spectroscopy,medical imaging
更新于2025-09-23 15:23:52
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[IEEE 2019 International Conference on Computer, Communication, Chemical, Materials and Electronic Engineering (IC4ME2) - Rajshahi, Bangladesh (2019.7.11-2019.7.12)] 2019 International Conference on Computer, Communication, Chemical, Materials and Electronic Engineering (IC4ME2) - Study of nonradiative recombination centers in GaAs:N ?′-doped superlattices structures revealed by below-gap excitation light
摘要： Susceptibility-weighted imaging (SWI) venography can produce detailed venous contrast and complement arterial dominated MR angiography (MRA) techniques. However, these dense reversed-contrast SWI venograms pose new segmentation challenges. We present an automatic method for whole-brain venous blood segmentation in SWI using Conditional Random Fields (CRF). The CRF model combines different first and second order potentials. First-order association potentials are modeled as the composite of an appearance potential, a Hessian-based shape potential and a non-linear location potential. Second-order interaction potentials are modeled using an auto-logistic (smoothing) potential and a data-dependent (edge) potential. Minimal post-processing is used for excluding voxels outside the brain parenchyma and visualizing the surface vessels. The CRF model is trained and validated using 30 SWI venograms acquired within a population of deep brain stimulation (DBS) patients (age range years). Results demonstrate robust and consistent segmentation in deep and sub-cortical regions (median and 0.82), as well as in challenging mid-sagittal and surface regions (median and 0.83) regions. Overall, this CRF model produces high-quality segmentation of SWI venous vasculature that finds applications in DBS for minimizing hemorrhagic risks and other surgical and non-surgical applications.
关键词： deep brain stimulation,Conditional random fields,susceptibility-weighted imaging,image-guided neurosurgery,MR venography
更新于2025-09-23 15:21:01
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[ACM Press the 12th International Conference - Eindhoven, Netherlands (2018.09.03-2018.09.04)] Proceedings of the 12th International Conference on Distributed Smart Cameras - ICDSC '18 - Hand-Eye Camera Calibration with an Optical Tracking System
摘要： This paper presents a method for hand-eye camera calibration via an optical tracking system (OTS) faciltating robotic applications. The camera pose cannot be directly tracked via the OTS. Because of this, a transformation matrix between a marker-plate pose, tracked via the OTS, and the camera pose needs to be estimated. To this end, we evaluate two different approaches for hand-eye calibration. In the first approach, the camera is in a fixed position and a 2D calibration plate is displaced. In the second approach, the camera is also fixed, but now a 3D calibration object is moved. The first step of our method consists of collecting N views of the marker-plate pose and the calibration plates, acquired via OTS. This is achieved by keeping the camera fixed and moving the calibration plate, while taking a picture of the calibration plate using the camera. A dataset is constructed that contains marker-plate poses and the relative camera poses. Afterwards, the transformation matrix is then computed, following a least-squares minimization. Accuracy in hand-eye calibration is computed in terms of re-projection error, calculated based on camera homography transformations. For both approaches, we measure the changes in accuracy as a function of the number of poses used for each calibration, while we define the minimum number of poses required to obtain a good camera calibration. Results of the experiments show similar performances for the two evaluated methods, achieving a median value of the re-projection error at N = 25 poses of 0.76 mm for the 2D calibration plate and 0.70 mm for the 3D calibration object. Also, we have found that minimally 15 poses are required to achieve a good camera calibration.
关键词： optical tracking system,neurosurgery,augmented reality,Hand-eye calibration,endoscope,tracking
更新于2025-09-23 15:21:01
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Fluorescence-Guided Neurosurgery (Neuro-oncology and Cerebrovascular Applications) || 1 Current Fluorescence-Guided Neurosurgery and Moving Forward
摘要： This introductory chapter provides a current overview of fluorescence-guided neurosurgery and includes future directions. The concepts of fluorescence and fluorescence-guided surgery (FGS) are introduced. Currently used fluorescent contrast agents in patients are summarized, including 5-aminolevulinic acid (5-ALA), fluorescein, and indocyanine green. Excitation light sources are discussed for each fluorescent contrast agent. Targeted fluorophores under clinical development for FGS are also introduced. Future directions in fluorescence-guided neurosurgery including handheld devices to better detect tumor fluorescence, dual fluorophore imaging, metabolic imaging in combination with FGS, and detection of the tumor margin will be discussed.
关键词： near-infrared imaging,fluorophore,indocyanine green,fluorescence-guided neurosurgery,fluorescence,operative microscope,fluorescence-guided surgery,fluorescein sodium,5-ALA
更新于2025-09-19 17:15:36
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[IEEE 2019 International Conference on 3D Vision (3DV) - Qu??bec City, QC, Canada (2019.9.16-2019.9.19)] 2019 International Conference on 3D Vision (3DV) - Decoupled Hybrid 360?° Panoramic Stereo Video
摘要： Susceptibility-weighted imaging (SWI) venography can produce detailed venous contrast and complement arterial dominated MR angiography (MRA) techniques. However, these dense reversed-contrast SWI venograms pose new segmentation challenges. We present an automatic method for whole-brain venous blood segmentation in SWI using Conditional Random Fields (CRF). The CRF model combines different first and second order potentials. First-order association potentials are modeled as the composite of an appearance potential, a Hessian-based shape potential and a non-linear location potential. Second-order interaction potentials are modeled using an auto-logistic (smoothing) potential and a data-dependent (edge) potential. Minimal post-processing is used for excluding voxels outside the brain parenchyma and visualizing the surface vessels. The CRF model is trained and validated using 30 SWI venograms acquired within a population of deep brain stimulation (DBS) patients (age range years). Results demonstrate robust and consistent segmentation in deep and sub-cortical regions (median and 0.82), as well as in challenging mid-sagittal and surface regions (median and 0.83) regions. Overall, this CRF model produces high-quality segmentation of SWI venous vasculature that finds applications in DBS for minimizing hemorrhagic risks and other surgical and non-surgical applications.
关键词： image-guided neurosurgery,Conditional random fields,deep brain stimulation,susceptibility-weighted imaging,MR venography
更新于2025-09-19 17:13:59
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Intraoperative Thermography of the Electrical Stimulation Mapping: A Safety Control Study
摘要： A standard procedure for continuous intraoperative monitoring of the integrity of the corticospinal tracts by eliciting muscle responses is the electric stimulation mapping (ESM). However, standard ESM protocols are ineffective in 20% of young children. We have developed a novel, highly efficient paradigm consisting of short-time burst (30 ms) of high frequency (500 Hz) and high peak current (≤100 mA), which may cause local tissue overheating. The presented safety control study was therefore designed. The infrared thermography camera captured to-be-resected cortex of 13 patients in vivo during ESM. Thermograms were image processed to reveal discrete ESM thermal effect of currents from 10 to 100 mA. Peak 100 mA currents induced a maximal increase in temperature of 3.1 °C, 1.23 ± 0.72 °C in average. The warming correlated with stimulating electrode resistance (p < 0.001). The measurement uncertainty was estimated ±1.01 °C for the most skeptical conditions. The histopathological evaluation of stimulated tissue (performed in all cases) did not show any destructive changes. Our study demonstrates the ability of the thermographic camera to measure the discrete thermal effect of the ESM. The results provide evidence for the safety of the proposed protocol for full range currents with minimal risk of brain tissue damage.
关键词： neurosurgery,safety control,Electrical stimulation mapping,thermography,thermal effect,in vivo
更新于2025-09-09 09:28:46
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Gesture-based registration correction using a mobile augmented reality image-guided neurosurgery system
摘要： In image-guided neurosurgery, a registration between the patient and their pre-operative images and the tracking of surgical tools enables GPS-like guidance to the surgeon. However, factors such as brainshift, image distortion, and registration error cause the patient-to-image alignment accuracy to degrade throughout the surgical procedure no longer providing accurate guidance. The authors present a gesture-based method for manual registration correction to extend the usage of augmented reality (AR) neuronavigation systems. The authors’ method, which makes use of the touchscreen capabilities of a tablet on which the AR navigation view is presented, enables surgeons to compensate for the effects of brainshift, misregistration, or tracking errors. They tested their system in a laboratory user study with ten subjects and found that they were able to achieve a median registration RMS error of 3.51 mm on landmarks around the craniotomy of interest. This is comparable to the level of accuracy attainable with previously proposed methods and currently available commercial systems while being simpler and quicker to use. The method could enable surgeons to quickly and easily compensate for most of the observed shift. Further advantages of their method include its ease of use, its small impact on the surgical workflow and its small-time requirement.
关键词： registration correction,brainshift,image-guided neurosurgery,neuronavigation,augmented reality
更新于2025-09-09 09:28:46
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Intraoperative detection of blood vessels with an imaging needle during neurosurgery in humans
摘要： Intracranial hemorrhage can be a devastating complication associated with needle biopsies of the brain. Hemorrhage can occur to vessels located adjacent to the biopsy needle as tissue is aspirated into the needle and removed. No intraoperative technology exists to reliably identify blood vessels that are at risk of damage. To address this problem, we developed an “imaging needle” that can visualize nearby blood vessels in real time. The imaging needle contains a miniaturized optical coherence tomography probe that allows differentiation of blood flow and tissue. In 11 patients, we were able to intraoperatively detect blood vessels (diameter, >500 mm) with a sensitivity of 91.2% and a specificity of 97.7%. This is the first reported use of an optical coherence tomography needle probe in human brain in vivo. These results suggest that imaging needles may serve as a valuable tool in a range of neurosurgical needle interventions.
关键词： intracranial hemorrhage,optical coherence tomography,neurosurgery,blood vessel detection,imaging needle
更新于2025-09-04 15:30:14
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<i>In Vivo</i> Confocal Microscopy Analysis of Corneal Microstructural Changes in Neurosurgically-Induced Neurotrophic Keratitis
摘要： Purpose: To investigate the changes of the corneal microstructure of neurosurgically-induced neurotrophic keratitis patients compared to normal human corneas using in vivo confocal microscope (IVCM). Methods: Ten eyes in the normal control group and 11 eyes in the neurosurgically-induced neurotrophic keratitis patient group were included in the present study. After corneal sensitivity tests were performed, thickness of each layer and number of endothelial cells and stromal keratocytes in the cornea were assessed using IVCM. Morphological characteristics of the corneal nerves were measured by ImageJ software. Results: After analysis of corneal thickness layer by layer, the Bowman’s layer was significantly reduced in the neurosurgically-induced neurotrophic keratitis patient group compared with the normal control group (p = 0.016) and the portion of Bowman’s layer was significantly reduced in the neurosurgically-induced neurotrophic keratitis patient group compared with the control group (p = 0.024). The nerve fiber length per square-millimeter became significantly shorter compared to the normal control group (p = 0.042). The nerve fiber length per square millimeter showed significant correlations with the number of fibers, number of beading, branching patterns, and nerve tortuosity (p = 0.002, 0.002, 0.013 and 0.034, respectively). The number of endothelial cells and stromal keratocytes, the number of nerve fibers and beading, and the pattern of branching and nerve tortuosity showed no significant differences between the normal and neurosurgically-induced neurotrophic keratitis patient groups. Conclusions: Our results showed that decreased thickness of Bowman’s layer may be related to the decreased corneal nerve distribution, secondary to the dysfunction of trigeminal nerve branch innervating the cornea. The microstructural changes of Bowman’s layer can help diagnose the disease and evaluate the current status in neurosurgically-induced neurotrophic keratitis patients.
关键词： Neurosurgically-induced neurotrophic keratitis,Corneal thickness,Corneal nerve,Confocal microscopy,Neurosurgery
更新于2025-09-04 15:30:14