685PA MULTICENTER PHASE II STUDY OF SALVAGE PHOTODYNAMIC THERAPY USING TALAPORFIN SODIUM AND A DIODE LASER FOR LOCAL FAILURE OF ESOPHAGEAL CANCER AFTER CHEMORADIOTHERAPY

摘要： We previously reported that photodynamic therapy (PDT) has a potential to cure local failure after chemoradiotherapy (CRT) for esophageal cancer (EC). However, first-generation PDT using porfimer sodium and an excimer dye laser has several problems: a high occurrence of skin phototoxicity, the requirement of a long light shielding period (6 weeks), and the need for an expensive and large laser generator. Talaporfin sodium (Laserphyrin?) is a second-generation photosensitizer that requires a shorter light shielding period (2 weeks) and induces less phototoxicity. We previously identified the optimum diode laser fluence (100 J/cm2) for PDT using talaporfin sodium in the phase I/IIA study. Therefore, in the present study, we conducted a multicenter phase IIB study to evaluate the efficacy and safety of PDT using talaporfin sodium as a salvage treatment for local failure after CRT or radiotherapy (RT) for EC. (UMIN000009184).